Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression

Journal of Thrombosis and Haemostasis

Volumn 6, Issue 6, 2008, Pages 1003-1011

  Ohlmann, P ^a,b,c   Hechler, B ^a,b,c   Ravanat, C ^a,b,c   Loyau, S ^d   Herrenschmidt, N ^e   Wanert, F ^e   Jandrot Perrus, Martine ^d   Gachet, C ^a  

^a INSERM   (France)

^b ETABLISSEMENT FRANÇAIS DU SANG   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d BICHAT HOSPITAL   (France)

^e Centre de Primatologie   (France)

Author keywords

Antibodies; Antithrombotics; Fab; GPVI; Nonhuman primate; Platelets

Indexed keywords

CD36 ANTIGEN; COLLAGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD36; PROTHROMBIN; THROMBOPLASTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING TEST; BLOOD SAMPLING; BOLUS INJECTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MECHANISM; EX VIVO STUDY; HEMOSTASIS; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTHROMBIN TIME; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE COUNT; THROMBUS;

ANIMALS; BLOOD PLATELETS; CONSTRICTION, PATHOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN FAB FRAGMENTS; MACACA FASCICULARIS; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET MEMBRANE GLYCOPROTEINS; PRIMATES; THROMBIN; THROMBOSIS; TIME FACTORS;

EID: 43749099001     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2008.02976.x     Document Type: Article

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