TGF-β receptors and signal transduction

International Journal of Hematology

Volumn 65, Issue 2, 1997, Pages 97-104

  Miyazono, Kohei ^a  

^a CANCER INSTITUTE   (Japan)

Author keywords

Growth inhibitor; Serine threonine kinase receptor; Signal transduction; TGF ; Tumor suppressor gene

Indexed keywords

PROTEIN SERINE THREONINE KINASE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER; HEMATOPOIESIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 0031081790     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0925-5710(96)00542-7     Document Type: Article

References (42)

1. [1] Miyazono K, ten Dijke P, Ichijo H, Heldin C-H. Receptors for transforming growth factor-β. Adv Immunol 1994;55:181-220.
2. [2] Shull MM, Ormsby I, Kier AB et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 1992;359:693-699.
3. [3] Kulkarni AB, Huh C-G, Becker D et al. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993;90:770-774.
4. A chain. Proc Natl Acad Sci USA 1988;85:2434-2438.
5. [5] Keller G, Kennedy M, Papayannopoulou T, Wiles MV. Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 1993;13:473-486.
6. [6] Miyazono K, ten Dijke P, Yamashita H, Heldin C-H. Signal transduction via serine threonine kinase receptors. Semin Cell Biol 1994;5:389-398.
7. [7] Henis YI, Moustakas A, Lin HY, Lodish HF. The types II and III transforming growth factor-β receptors form homo-oligomers. J Cell Biol 1994;126:139-154.
8. [8] López-Casillas F, Payne HM, Andres JL, Massagué J. Betaglycan can act as dual modulator of TGF-β access to signaling receptors: mapping of ligand binding and GAG attachment sites. J Cell Biol 1994;124:557-568.
9. [9] Pepin M-C, Beauchemin M, Plamondon J, O'Connor-McCourt MD. Mapping of the ligand binding domain of the transforming growth factor β receptor type III by deletion mutagenesis. Proc Natl Acad Sci USA 1994; 91:6997-7001.
10. [10] López-Casillas F, Wrana JL, Massagué J. Betaglycan presents ligand to the TGFβ signaling receptor. Cell 1993;73:1435-1444.
11. [11] Cheifetz S, Bellón T, Calés C et al. Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells. J Biol Chem 1992;267:19027-19030.
12. [12] Yamashita H, Ichijo H, Grimsby S, Morén A, ten Dijke P, Miyazono K. Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-β. J Biol Chem 1994;269:1995-2001.
13. [13] McAllister KA, Grogg KM, Johnson DW et al. Endoglin. a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nature Genet 1994;8:345-351.
14. [14] Lin HY, Wang X-F, Ng-Eaton E, Weinberg RA, Lodish HF. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine threonine kinase. Cell 1992;68:775-785.
15. [15] Franzén P, ten Dijke P, Ichijo H et al. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell 1993;75:681-692.
16. [16] Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-β receptor. Nature 1994;370:341-347.
17. [17] ten Dijke P, Yamashita H, Ichijo H et al. Characterization of type I receptors for transforming growth factor-β and activin. Science 1994;265:101-104.
18. [18] Johnson DW, Berg JN, Baldwin MA et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nature Genet 1996;13:189-195.
19. [19] Wrana JL, Attisano L, Cärcamo J el al. TGFβ signals through a heteromeric protein kinase receptor complex. Cell 1992;71:1003-1014.
20. [20] Chen R-H, Derynck R. Homomeric interactions between type II transforming growth factor-β receptors. J Biol Chem 1994;269:22868-22874.
21. [21] Yamashita H, ten Dijke P, Franzén P, Miyazono K, Heldin C-H. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β. J Biol Chem 1994;269:20172-20178.
22. [22] Weis-Garcia F, Massagué J. Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor cooperatively essential for signaling. EMBO J 1996;15:276-289.
23. [23] Cärcamo J, Weis FMB, Ventura F et al. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol Cell Biol 1994;14:3810-3821.
24. [24] Wieser R, Wrana JL, Massagué J. GS domain mutations that constitutively activate TβR-1, the downstream signaling component in the TGF-β receptor complex. EMBO J 1995;14:2199-2208.
25. [25] Hoodless PA, Haerry T, Abdollah S et al. MAOR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 1996;85:489-500.
26. [26] Wang T, Donahoe PK, Zervos AS. Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP12. Science 1994;265:674-676.
27. [27] Kawabata M, Imamura T, Miyazono K et al. Interaction of the transforming growth factor-β type I receptor with farnesyl-protein transferase-χ. J Biol Chem 1995;270: 29628-29631.
28. Ras farnesyltransferase χ subunit in TGF-β and activin signaling. Science 1996;271:1120-1122.
29. [29] Ventura F, Liu F, Doody J et al. Interaction of transforming growth factor-β receptor with farnesyl-protein transferase-χ in yeast and mammalian cells. J Biol Chem 1996;271:13931-13934.
30. [30] Chen R-H, Miettinen PJ, Maruoka EM et al. A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature 1995;377:548-552.
31. [31] Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM. Genetic characterization and cloning of Mothers against dpp. a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 1995;139: 1347-1358.
32. [32] Hahn SA, Schutte M, Hoque ATMS et al. DPC4. a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-353.
33. [33] Liu F, Hata A, Baker JC et al. A human Mad protein acting as a BMP-regulated transcriptional activalor. Nature 1996;381:620-623.
34. [34] Graff JM, Bansal A, Melton DA. Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 1996;85:479-487.
35. [35] Lechleider RJ, de Caestecker MP, Dehejia A, Polymeropoulos MH, Roberts AB. Serine phosphorylation, chromosomal localization and TGF-β signal transduction by human bsp-1. J Biol Chem 1996; 271:17617-17620.
36. [36] Yamaguchi K, Shirakabe K, Shibuya H et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 1995;270:2008-2011.
37. [37] Moriguchi T, Kuroyanagi N, Yamaguchi K et al. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem 1996;271:13675-13679.
38. [38] Markowitz S, Wang J, Myeroff L et al. Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability. Science 1995;268:1336-1338.
39. [39] Knaus PI, Lindemann D, DeCoteau JF et al. A dominant inhibitory mutant of the type II transforming growth factor β receptor in the malignant progression of a cutaneous T-cell lymphoma. Mol Cell Biol 1996;16:3480-3489.
40. [40] Thiagalingam S, Lengauer C, Leach FE et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genet 1996;13:343-346.
41. [41] Riggins GJ, Thiagalingam S, Rozenblum E et al. Mad-related genes in the human. Nature Genet 1996;13:347-349.
42. [42] Reynisdottir I, Polyak K, Iavarone A et al. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev 1995;9:1831-1845.