Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived fab fragments

Journal of Thrombosis and Haemostasis

Volumn 1, Issue 12, 2003, Pages 2653-2662

  Lecut, C ^a   Feeney, L A ^a   Kingsbury, G ^a   Hopkins, J ^a   Lanza, F ^b   Gachet, C ^b   Villeval, J L ^a   Jandrot Perrus, Jandrot Perrus ^a  

^a INSERM   (France)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Antagonist; Antithrombotic; GPVI; Platelet

Indexed keywords

COLLAGEN; CONVULXIN; FIBRINOGEN RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; LECTIN; MONOCLONAL ANTIBODY; PLATELET MEMBRANE GLYCOPROTEIN VI; SNAKE VENOM;

ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PERFUSION; PHYSIOLOGY; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESIVENESS; THROMBOSIS;

ANTIBODIES, MONOCLONAL; COLLAGEN; CROTALID VENOMS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; LECTINS, C-TYPE; PERFUSION; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET MEMBRANE GLYCOPROTEINS; THROMBOSIS;

EID: 1542755135     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2003.00495.x     Document Type: Article

References (30)

1. Clemetson KJ, Clemetson JM. Platelet collagen receptors. Thromb Haemost 2001; 86: 189-97.
2. Moroi M, Jung SM, Okuma M, Shinmyozu K. A patient with platelets deficient in glycoprotein VI that lackboth collagen-induced aggregation and adhesion. J Clin Invest 1989; 84: 1440-5.
3. Kehrel B, Wierwille S, Clemetson KJ, Anders O, Steiner M, Knight CG, Farndale RW, Okuma M, Barnes MJ. Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood 1998; 91: 491-9.
4. Heemskerk JW, Siljander P, Vuist WM, Breikers G, Reutelingsperger CP, Barnes MJ, Knight CG, Lassila R, Farndale RW. Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets. Thromb Haemost 1999; 81: 782-92.
5. Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J 2001; 20: 2120-30.
6. Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chick-ering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood 2000; 96: 1798-807.
7. Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phos-phorylation of the Fc receptor gamma-chain. FEBS Lett 1997; 413: 255-9.
8. Nieswandt B, Schulte V, Bergmeier W, Mokhtari-Nejad R, Rackebrandt K, Cazenave JP, Ohlmann P, Gachet C, Zirngibl H. Long-term antith-rombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med 2001; 193: 459-69.
9. Konishi H, Katoh Y, Takaya N, Kashiwakura Y, Itoh S, Ra C, Daida H. Platelets activated by collagen through immunoreceptor tyrosine-based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injury. Circulation 2002; 105: 912-6.
10. Arai M, Yamamoto N, Moroi M, Akamatsu N, Fukutake K, Tanoue K. Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency. Br J Haematol 1995; 89: 124-30.
11. Sugiyama T, Okuma M, Ushikubi F, Sensaki S, Kanaji K, Uchino H. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocyto-penia. Blood 1987; 69: 1712-20.
12. Goto S, Tamura N, Handa S, Arai M, Kodama K, Takayama H. Involvement of glycoprotein VI in platelet thrombus formation on both collagen and von Willebrand factor surfaces under flow conditions. Circulation 2002; 106: 266-72.
13. Bezeaud A, Denninger MH, Guillin MC. Interaction of human alpha-thrombin and gamma-thrombin with antithrombin III, protein C and thrombomodulin. Eur J Biochem 1985; 153: 491-6.
14. Francischetti IM, Saliou B, Leduc M, Carlini CR, Hatmi M, Randon J, Faili A, Bon C. Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets. Toxicon 1997; 35: 1217-28.
15. Morton LF, Hargreaves PG, Farndale RW, Young RD, Barnes MJ. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-indepen-dent platelet reactivity. Biochem J 1995; 306: 337-44.
16. Jandrot-Perrus M, Lagrue AH, Okuma M, Bon C. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1. J Biol Chem 1997; 272: 27035-41.
17. Lagrue-Lak-Hal AH, Debili N, Kingbury G, Lecut C, Le Couedic JP, Villeval JL, Jandrot-Perrus M, Vainchenker W. Expression and function of the collagen receptor GPVI during megakaryocyte maturation. J Biol Chem 2001; 276: 15316-25.
18. Moog S, Mangin P, Lenain N, Strassel C, Ravanat C, Schuhler S, Freund M, Santer M, Kahn M, Nieswandt B, Gachet C, Cazenave JP, Lanza F. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. Blood 2001; 98: 1038-46.
19. Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ. The platelet collagen receptor glycoprotein VI is a member of the immuno-globulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem 1999; 274: 29019-24.
20. Jarvis GE, Atkinson BT, Snell DC, Watson SP. Distinct roles of GPVI and integrin alpha (2) beta (1) in platelet shape change and aggregation induced by different collagens. Br J Pharmacol 2002; 137: 107-17.
21. Schulte V, Snell D, Bergmeier W, Zirngibl H, Watson SP, Nieswandt B. Evidence for two distinct epitopes within collagen for activation of murine platelets. J Biol Chem 2001; 276: 364-8.
22. Niedergang F, Alcover A, Knight CG, Farndale RW, Barnes MJ, Francischetti IM, Bon C, Leduc M. Convulxin binding to platelet receptor GPVI. Competition with collagen related peptides. Biochem Biophys Res Commun 2000; 273: 246-50.
23. Miura Y, Takahashi T, Jung SM, Moroi M. Analysis of the interaction of platelet collagen receptor glycoprotein VI with collagen: a dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. J Biol Chem 2002; 29: 29.
24. Wines BD, Sardjono CT, Trist HH, Lay CS, Hogarth PM. The inter-action of Fc alpha RI with IgA and its implications for ligand binding by immunoreceptors of the leukocyte receptor cluster. J Immunol 2001; 166: 1781-9.
25. Gibbins J, Asselin J, Farndale R, Barnes M, Law CL, Watson SP. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets. J Biol Chem 1996; 271: 18095-9.
26. Chacko GW, Brandt JT, Coggeshall KM, Anderson CL. Phosphoinosi-tide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phospho-peptides. J Biol Chem 1996; 271: 10775-81.
27. Orloff DG, Ra CS, FrankSJ, Klausner RD, Kinet JP. Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature 1990; 347: 189-91.
28. Sixma JJ, van Zanten GH, Huizinga EG, van der Plas RM, Verkley M, Wu YP, Gros P, de Groot PG. Platelet adhesion to collagen: an update. Thromb Haemost 1997; 78: 434-8.
29. Barnes MJ, Knight CG, Farndale RW. The collagen-platelet interaction. Curr Opin Hematol 1998; 5: 314-20.
30. Watson S, Berlanga O, Best D, Frampton J. Update on collagen receptor interactions in platelets: is the two-state model still valid? Platelets 2000; 11: 252-8.