SREBP and MDT-15 protect C. Elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

Genes and Development

Volumn 29, Issue 23, 2015, Pages 2490-2503

  Lee, Dongyeop ^a   Jeong, Dae Eun ^a   Son, Heehwa G ^a   Yamaoka, Yasuyo ^a   Kim, Hyunmin ^b   Seo, Keunhee ^a   Khan, Abdul Aziz ^a   Roh, Tae Young ^a   Moon, Dae Won ^b   Lee, Youngsook ^a   Lee, Seung Jae V ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

Aging; C. elegans; Fat; Glucose; MDT 15; SREBP

Indexed keywords

GLUCOSE; SATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MDT 15; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; ACYL COENZYME A DESATURASE; CAENORHABDITIS ELEGANS PROTEIN; FATTY ACID; MDT-15 PROTEIN, C ELEGANS; SUGAR INTAKE;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENDOCYTOSIS; GENETIC SCREENING; GLUCOSE INTAKE; GLUCOTOXICITY; GLYCOLYSIS; LIFESPAN; METABOLITE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; DIET; DRUG EFFECTS; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; PHARMACOLOGY; RNA INTERFERENCE; SUGAR INTAKE;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DIET; DIETARY SUCROSE; ENZYME INDUCTION; FATTY ACID DESATURASES; FATTY ACIDS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE; RNA INTERFERENCE; STEROL REGULATORY ELEMENT BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 84957831219     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.266304.115     Document Type: Article

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