RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 31, 2015, Pages E4246-E4255

  Seo, Mihwa ^a,b   Seo, Keunhee ^b   Hwang, Wooseon ^b   Koo, Hee Jung ^a,b   Hahm, Jeong Hoon ^a   Yang, Jae Seong ^b,d   Han, Seong Kyu ^b   Hwang, Daehee ^a,c   Kim, Sanguk ^b   Jang, Sung Key ^b   Lee, Yoontae ^b   Nam, Hong Gil ^a,c   Lee, Seung Jae V ^b  

^a Institute for Basic Science   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

^d CENTRE FOR GENOMIC REGULATION CRG   (Spain)

Author keywords

Aging; C. Elegans; FOXO; Insulin IGF 1; RNA helicase

Indexed keywords

DEAD BOX PROTEIN; HELICASE 1; SOMATOMEDIN; SOMATOMEDIN 1; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; DAF-2 PROTEIN, C ELEGANS; FORKHEAD TRANSCRIPTION FACTOR; HEL-1 PROTEIN, C ELEGANS; INSULIN; INSULIN RECEPTOR; MESSENGER RNA; PROTEIN BINDING; RNA HELICASE; SOMATOMEDIN C;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE ONTOLOGY; HEAT STRESS; INTESTINE; LIFESPAN; LONGEVITY; MITOCHONDRIAL RESPIRATION; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PSEUDOMONAS AERUGINOSA; REGULATORY MECHANISM; RNA SEQUENCE; SIGNAL TRANSDUCTION; TRANSGENE; ANIMAL; ENZYMOLOGY; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REPRODUCTION; RNA INTERFERENCE; SEQUENCE ANALYSIS; UPREGULATION;

CAENORHABDITIS ELEGANS; MAMMALIA;

ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; GENES, HELMINTH; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTESTINES; LONGEVITY; MOLECULAR SEQUENCE DATA; MUTATION; NEURONS; PROTEIN BINDING; RECEPTOR, INSULIN; REPRODUCTION; RNA HELICASES; RNA INTERFERENCE; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84938629424     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505451112     Document Type: Article

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