-
1
-
-
0042626242
-
-
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.
-
An JH, Blackwell TK (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes. Dev. 17, 1882-1893.
-
(2003)
Genes. Dev.
, vol.17
, pp. 1882-1893
-
-
An, J.H.1
Blackwell, T.K.2
-
3
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
4
-
-
34250759430
-
Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans
-
Brock TJ, Browse J, Watts JL (2007) Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Genetics 176, 865-875.
-
(2007)
Genetics
, vol.176
, pp. 865-875
-
-
Brock, T.J.1
Browse, J.2
Watts, J.L.3
-
5
-
-
34250760886
-
Small-molecule pheromones that control dauer development in Caenorhabditis elegans
-
Butcher RA, Fujita M, Schroeder FC, Clardy J (2007) Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nat. Chem. Biol. 3, 420-422.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 420-422
-
-
Butcher, R.A.1
Fujita, M.2
Schroeder, F.C.3
Clardy, J.4
-
6
-
-
66349105688
-
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
-
Choe KP, Przybysz AJ, Strange K (2009) The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol. Cell. Biol. 29, 2704-2715.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 2704-2715
-
-
Choe, K.P.1
Przybysz, A.J.2
Strange, K.3
-
7
-
-
79953162883
-
Function and regulation of the Mediator complex
-
Conaway RC, Conaway JW (2011) Function and regulation of the Mediator complex. Curr. Opin. Genet. Dev. 21, 225-230.
-
(2011)
Curr. Opin. Genet. Dev.
, vol.21
, pp. 225-230
-
-
Conaway, R.C.1
Conaway, J.W.2
-
8
-
-
50049116926
-
C. elegans dauer formation and the molecular basis of plasticity
-
Fielenbach N, Antebi A (2008) C. elegans dauer formation and the molecular basis of plasticity. Genes Dev. 22, 2149-2165.
-
(2008)
Genes Dev.
, vol.22
, pp. 2149-2165
-
-
Fielenbach, N.1
Antebi, A.2
-
9
-
-
80053124673
-
Taking a 'good look' at free radicals in the aging process
-
Hekimi S, Lapointe J, Wen Y (2011) Taking a 'good look' at free radicals in the aging process. Trends Cell Biol. 21, 569-576.
-
(2011)
Trends Cell Biol.
, vol.21
, pp. 569-576
-
-
Hekimi, S.1
Lapointe, J.2
Wen, Y.3
-
10
-
-
0035846604
-
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson ST, Johnson TE (2005) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11, 1975-1980.
-
(2005)
Curr. Biol.
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
11
-
-
77952005717
-
Mechanism of Mediator recruitment by Tandem Gcn4 activation domains and three Gal11 activator-binding domains
-
Herbig E, Warfield L, Fish L, Fishburn J, Knutson BA, Moorefield B, Pacheco D, Hahn S (2010) Mechanism of Mediator recruitment by Tandem Gcn4 activation domains and three Gal11 activator-binding domains. Mol. Cell. Biol. 30, 2376-2390.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 2376-2390
-
-
Herbig, E.1
Warfield, L.2
Fish, L.3
Fishburn, J.4
Knutson, B.A.5
Moorefield, B.6
Pacheco, D.7
Hahn, S.8
-
12
-
-
70450240760
-
Fatty-acid metabolism is involved in stress-resistance mechanisms of Caenorhabditis elegans
-
Horikawa M, Sakamoto K (2009) Fatty-acid metabolism is involved in stress-resistance mechanisms of Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 390, 1402-1407.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.390
, pp. 1402-1407
-
-
Horikawa, M.1
Sakamoto, K.2
-
13
-
-
84866365418
-
Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging
-
Hou NS, Taubert S (2012) Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging. Front. Physiol. 3, 143.
-
(2012)
Front. Physiol.
, vol.3
, pp. 143
-
-
Hou, N.S.1
Taubert, S.2
-
14
-
-
77449125295
-
Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo
-
Jedidi I, Zhang F, Qiu H, Stahl SJ, Palmer I, Kaufman JD, Nadaud PS, Mukherjee S, Wingfield PT, Jaroniec CP, Hinnebusch AG (2010) Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo. J. Biol. Chem. 285, 2438-2455.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2438-2455
-
-
Jedidi, I.1
Zhang, F.2
Qiu, H.3
Stahl, S.J.4
Palmer, I.5
Kaufman, J.D.6
Nadaud, P.S.7
Mukherjee, S.8
Wingfield, P.T.9
Jaroniec, C.P.10
Hinnebusch, A.G.11
-
15
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
-
Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-237.
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
Fraser, A.G.2
Dong, Y.3
Poulin, G.4
Durbin, R.5
Gotta, M.6
Kanapin, A.7
Le Bot, N.8
Moreno, S.9
Sohrmann, M.10
Welchman, D.P.11
Zipperlen, P.12
Ahringer, J.13
-
16
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
17
-
-
0038707371
-
A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans
-
Leiers B, Kampkötter A, Grevelding CG, Link CD, Johnson TE, Henkle-Dührsen K (2003) A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radic. Biol. Med. 34, 1405-1415.
-
(2003)
Free Radic. Biol. Med.
, vol.34
, pp. 1405-1415
-
-
Leiers, B.1
Kampkötter, A.2
Grevelding, C.G.3
Link, C.D.4
Johnson, T.E.5
Henkle-Dührsen, K.6
-
18
-
-
77957364935
-
The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans
-
Liang B, Ferguson K, Kadyk L, Watts JL (2010) The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS ONE 5, e9869.
-
(2010)
PLoS ONE
, vol.5
-
-
Liang, B.1
Ferguson, K.2
Kadyk, L.3
Watts, J.L.4
-
19
-
-
0345447590
-
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
-
Libina N, Berman JR, Kenyon C (2003) Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115, 489-502.
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
21
-
-
77049114949
-
Transcriptional responses to oxidative stress: pathological and toxicological implications
-
Ma Q (2010) Transcriptional responses to oxidative stress: pathological and toxicological implications. Pharmacol. Ther. 125, 376-393.
-
(2010)
Pharmacol. Ther.
, vol.125
, pp. 376-393
-
-
Ma, Q.1
-
22
-
-
77958111633
-
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
-
Malik S, Roeder RG (2010) The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 11, 761-772.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 761-772
-
-
Malik, S.1
Roeder, R.G.2
-
23
-
-
84858341125
-
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals
-
McCormick M, Chen K, Ramaswamy P, Kenyon C (2011) New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell 11, 192-202.
-
(2011)
Aging Cell
, vol.11
, pp. 192-202
-
-
McCormick, M.1
Chen, K.2
Ramaswamy, P.3
Kenyon, C.4
-
24
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
25
-
-
61449165764
-
Nuclear receptor-like transcription factors in fungi
-
Naar AM, Thakur JK (2009) Nuclear receptor-like transcription factors in fungi. Genes Dev. 23, 419-432.
-
(2009)
Genes Dev.
, vol.23
, pp. 419-432
-
-
Naar, A.M.1
Thakur, J.K.2
-
26
-
-
70350625466
-
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
-
Oliveira RP, Abate JP, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK (2009) Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8, 524-541.
-
(2009)
Aging Cell
, vol.8
, pp. 524-541
-
-
Oliveira, R.P.1
Abate, J.P.2
Dilks, K.3
Landis, J.4
Ashraf, J.5
Murphy, C.T.6
Blackwell, T.K.7
-
27
-
-
66149175591
-
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
-
Park S-K, Tedesco PM, Johnson TE (2009) Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 8, 258-269.
-
(2009)
Aging Cell
, vol.8
, pp. 258-269
-
-
Park, S.-K.1
Tedesco, P.M.2
Johnson, T.E.3
-
28
-
-
84860545577
-
Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships
-
Ashrafi K, ed.).
-
Pathare PP, Lin A, Bornfeldt KE, Taubert S, Van Gilst MR (2012) Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships (Ashrafi K, ed.). PLoS Genet. 8, e1002645.
-
(2012)
PLoS Genet.
, vol.8
-
-
Pathare, P.P.1
Lin, A.2
Bornfeldt, K.E.3
Taubert, S.4
Van Gilst, M.R.5
-
29
-
-
67349276677
-
Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone
-
Przybysz AJ, Choe KP, Roberts LJ, Strange K (2009) Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mech. Ageing Dev. 130, 357-369.
-
(2009)
Mech. Ageing Dev.
, vol.130
, pp. 357-369
-
-
Przybysz, A.J.1
Choe, K.P.2
Roberts, L.J.3
Strange, K.4
-
30
-
-
79959981053
-
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
-
Rogers AN, Chen D, Mccoll G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P (2011) Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 14, 55-66.
-
(2011)
Cell Metab.
, vol.14
, pp. 55-66
-
-
Rogers, A.N.1
Chen, D.2
Mccoll, G.3
Czerwieniec, G.4
Felkey, K.5
Gibson, B.W.6
Hubbard, A.7
Melov, S.8
Lithgow, G.J.9
Kapahi, P.10
-
31
-
-
84864622015
-
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways
-
Shore DE, Carr CE, Ruvkun G (2012) Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 8, e1002792.
-
(2012)
PLoS Genet.
, vol.8
-
-
Shore, D.E.1
Carr, C.E.2
Ruvkun, G.3
-
32
-
-
33745178477
-
A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans
-
Taubert S, Van Gilst MR, Hansen M, Yamamoto KR (2006) A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 20, 1137-1149.
-
(2006)
Genes Dev.
, vol.20
, pp. 1137-1149
-
-
Taubert, S.1
Van Gilst, M.R.2
Hansen, M.3
Yamamoto, K.R.4
-
33
-
-
40149104005
-
The Mediator subunit MDT-15 confers metabolic adaptation to ingested material
-
Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR (2008) The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet. 4, e1000021.
-
(2008)
PLoS Genet.
, vol.4
-
-
Taubert, S.1
Hansen, M.2
Van Gilst, M.R.3
Cooper, S.B.4
Yamamoto, K.R.5
-
34
-
-
79951675235
-
Nuclear hormone receptors in nematodes: evolution and function
-
Taubert S, Ward JD, Yamamoto KR (2011) Nuclear hormone receptors in nematodes: evolution and function. Mol. Cell. Endocrinol. 334, 49-55.
-
(2011)
Mol. Cell. Endocrinol.
, vol.334
, pp. 49-55
-
-
Taubert, S.1
Ward, J.D.2
Yamamoto, K.R.3
-
35
-
-
41649118757
-
A nuclear receptor-like pathway regulating multidrug resistance in fungi
-
Thakur JK, Arthanari H, Yang F, Pan S-J, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM (2008) A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452, 604-609.
-
(2008)
Nature
, vol.452
, pp. 604-609
-
-
Thakur, J.K.1
Arthanari, H.2
Yang, F.3
Pan, S.-J.4
Fan, X.5
Breger, J.6
Frueh, D.P.7
Gulshan, K.8
Li, D.K.9
Mylonakis, E.10
Struhl, K.11
Moye-Rowley, W.S.12
Cormack, B.P.13
Wagner, G.14
Näär, A.M.15
-
36
-
-
63249102415
-
Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p
-
Thakur JK, Arthanari H, Yang F, Chau KH, Wagner G, Näär AM (2009) Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. J. Biol. Chem. 284, 4422-4428.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 4422-4428
-
-
Thakur, J.K.1
Arthanari, H.2
Yang, F.3
Chau, K.H.4
Wagner, G.5
Näär, A.M.6
-
37
-
-
2342487990
-
Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes
-
Thorpe GW, Fong CS, Alic N, Higgins VJ, Dawes IW (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc. Natl Acad. Sci. 101, 6564-6569.
-
(2004)
Proc. Natl Acad. Sci.
, vol.101
, pp. 6564-6569
-
-
Thorpe, G.W.1
Fong, C.S.2
Alic, N.3
Higgins, V.J.4
Dawes, I.W.5
-
38
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet JMA, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132, 1025-1038.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.A.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
39
-
-
15744386624
-
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans
-
Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol. 3, e53.
-
(2005)
PLoS Biol.
, vol.3
-
-
Van Gilst, M.R.1
Hadjivassiliou, H.2
Jolly, A.3
Yamamoto, K.R.4
-
40
-
-
77957583314
-
RNAi Screening Implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition
-
Wang J, Robida-Stubbs S, Tullet JMA, Rual J-F, Vidal M, Blackwell TK (2010) RNAi Screening Implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet. 6, e1001048.
-
(2010)
PLoS Genet.
, vol.6
-
-
Wang, J.1
Robida-Stubbs, S.2
Tullet, J.M.A.3
Rual, J.-F.4
Vidal, M.5
Blackwell, T.K.6
-
41
-
-
23344450788
-
Induction of phase I, II and III drug metabolism/transport by xenobiotics
-
Xu C, Li CY-T, Kong A-NT (2005) Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 28, 249-268.
-
(2005)
Arch. Pharm. Res.
, vol.28
, pp. 249-268
-
-
Xu, C.1
Li, C.-T.2
Kong, A.-N.3
-
42
-
-
33747053907
-
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
-
Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun Z-Y, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM (2006) An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 442, 700-704.
-
(2006)
Nature
, vol.442
, pp. 700-704
-
-
Yang, F.1
Vought, B.W.2
Satterlee, J.S.3
Walker, A.K.4
Jim Sun, Z.-Y.5
Watts, J.L.6
DeBeaumont, R.7
Saito, R.M.8
Hyberts, S.G.9
Yang, S.10
Macol, C.11
Iyer, L.12
Tjian, R.13
van den Heuvel, S.14
Hart, A.C.15
Wagner, G.16
Näär, A.M.17
-
43
-
-
80054703165
-
Redox control of the survival of healthy and diseased cells
-
Zhang Y, Du Y, Le W, Wang K, Kieffer N, Zhang J (2011) Redox control of the survival of healthy and diseased cells. Antioxid. Redox Signal. 15, 2867-2908.
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 2867-2908
-
-
Zhang, Y.1
Du, Y.2
Le, W.3
Wang, K.4
Kieffer, N.5
Zhang, J.6
-
44
-
-
84872143888
-
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators
-
Zhang P, Judy M, Lee S-J, Kenyon C (2013) Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab. 17, 85-100.
-
(2013)
Cell Metab.
, vol.17
, pp. 85-100
-
-
Zhang, P.1
Judy, M.2
Lee, S.-J.3
Kenyon, C.4
|