Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1740, Issue 3, 2005, Pages 427-433

  Takahashi, Akimitsu ^a   Shimano, Hitoshi ^a   Nakagawa, Yoshimi ^a   Yamamoto, Takashi ^a   Motomura, Kaori ^a   Matsuzaka, Takashi ^a   Sone, Hirohito ^a   Suzuki, Hiroaki ^a   Toyoshima, Hideo ^a   Yamada, Nobuhiro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Insulin resistance; Lipodystrophy; Liver steatosis; SREBP 1a transgenic mouse; Transcription factor

Indexed keywords

GLUCOSE; LEPTIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); STEROL REGULATORY ELEMENT BINDING PROTEIN 1A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN METABOLISM; INSULIN RESISTANCE; LIVER; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

ANIMALS; BLOOD GLUCOSE; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; MICE; MICE, TRANSGENIC; PANCREAS; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); POSTPRANDIAL PERIOD; PROMOTER REGIONS (GENETICS); STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

MUS MUSCULUS;

EID: 20444388685     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.11.006     Document Type: Article

References (32)

1. M.S. Brown, and J.L. Goldstein The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331 340
2. M.S. Brown, and J.L. Goldstein A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc. Natl. Acad. Sci. U. S. A. 96 1999 11041 11048
3. M.S. Brown, J. Ye, R.B. Rawson, and J.L. Goldstein Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans Cell 100 2000 391 398
4. H. Shimano Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver Trends Cardiovasc. Med. 10 2000 275 278
5. H. Shimano Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes Prog. Lipid Res. 40 2001 439 452
6. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
7. H. Shimano, N. Yahagi, M. Amemiya-Kudo, A.H. Hasty, J. Osuga, Y. Tamura, F. Shionoiri, Y. Iizuka, K. Ohashi, K. Harada, T. Gotoda, S. Ishibashi, and N. Yamada Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes J. Biol. Chem. 274 1999 35832 35839
8. G. Liang, J. Yang, J.D. Horton, R.E. Hammer, J.L. Goldstein, and M.S. Brown Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c J. Biol. Chem. 277 2002 9520 9528
9. H.J. Kim, M. Takahashi, and O. Ezaki Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs J. Biol. Chem. 274 1999 25892 25898
10. T.S. Worgall, S.L. Sturley, T. Seo, T.F. Osborne, and R.J. Deckelbaum Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein J. Biol. Chem. 273 1998 25537 25540
11. D.P. Thewke, S.R. Panini, and M. Sinensky Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins J. Biol. Chem. 273 1998 21402 21407
12. N. Yahagi, H. Shimano, A.H. Hasty, M. Amemiya-Kudo, H. Okazaki, Y. Tamura, Y. Iizuka, F. Shionoiri, K. Ohashi, J. Osuga, K. Harada, T. Gotoda, R. Nagai, S. Ishibashi, and N. Yamada A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids J. Biol. Chem. 274 1999 35840 35844
13. J.D. Horton, Y. Bashmakov, I. Shimomura, and H. Shimano Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice Proc. Natl. Acad. Sci. U. S. A. 95 1998 5987 5992
14. H. Shimano, J.D. Horton, R.E. Hammer, I. Shimomura, M.S. Brown, and J.L. Goldstein Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a J. Clin. Invest. 98 1996 1575 1584
15. J.B. Kim, P. Sarraf, M. Wright, K.M. Yao, E. Mueller, G. Solanes, B.B. Lowell, and B.M. Spiegelman Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J. Clin. Invest. 101 1998 1 9
16. M. Foretz, C. Guichard, P. Ferre, and F. Foufelle Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes Proc. Natl. Acad. Sci. U. S. A. 96 1999 12737 12742
17. I. Shimomura, Y. Bashmakov, S. Ikemoto, J.D. Horton, M.S. Brown, and J.L. Goldstein Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes Proc. Natl. Acad. Sci. U. S. A. 96 1999 13656 13661
18. M. Foretz, C. Pacot, I. Dugail, P. Lemarchand, C. Guichard, X. Le Liepvre, C. Berthelier-Lubrano, B. Spiegelman, J.B. Kim, P. Ferre, and F. Foufelle ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose Mol. Cell. Biol. 19 1999 3760 3768
19. A.H. Hasty, H. Shimano, N. Yahagi, M. Amemiya-Kudo, S. Perrey, T. Yoshikawa, J. Osuga, H. Okazaki, Y. Tamura, Y. Iizuka, F. Shionoiri, K. Ohashi, K. Harada, T. Gotoda, R. Nagai, S. Ishibashi, and N. Yamada Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level J. Biol. Chem. 275 2000 31069 31077
20. T. Ide, H. Shimano, N. Yahagi, T. Matsuzaka, M. Nakakuki, T. Yamamoto, Y. Nakagawa, A. Takahashi, H. Suzuki, H. Sone, H. Toyoshima, A. Fukamizu, and N. Yamada SREBPs suppress IRS-2-mediated insulin signalling in the liver Nat. Cell Biol. 6 2004 351 357
21. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
22. J. Moitra, M.M. Mason, M. Olive, D. Krylov, O. Gavrilova, B. Marcus-Samuels, L. Feigenbaum, E. Lee, T. Aoyama, M. Eckhaus, M.L. Reitman, and C. Vinson Life without white fat: a transgenic mouse Genes Dev. 12 1998 3168 3181
23. L.A. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G.J. Richards, L.A. Campfield, F.T. Clark, and J. Deeds Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263 1271
24. W.I. Sivitz, S.A. Walsh, D.A. Morgan, M.J. Thomas, and W.G. Haynes Effects of leptin on insulin sensitivity in normal rats Endocrinology 138 1997 3395 3401
25. I. Shimomura, R.E. Hammer, S. Ikemoto, M.S. Brown, and J.L. Goldstein Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
26. I. Shimomura, R.E. Hammer, J.A. Richardson, S. Ikemoto, Y. Bashmakov, J.L. Goldstein, and M.S. Brown Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy Genes Dev. 12 1998 3182 3194
27. R.H. Unger Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications Diabetes 44 1995 863 870
28. M.A. Puchowicz, I.R. Bederman, B. Comte, D. Yang, F. David, E. Stone, K. Jabbour, D.H. Wasserman, and H. Brunengraber Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA Am. J. Physiol. 277 1999 E1022 E1027
29. W. Zingg, A.M. Rappaport, and B.S. Leibel Transhepatic absorption and biliary excretion of insulin Can. J. Physiol. Pharm. 65 1987 1982 1987
30. W. Zingg, A.M. Rappaport, and B.S. Leibel Studies on transhepatic insulin absorption Can. J. Physiol. Pharm. 64 1986 231 234
31. T. Ishida, Z. Chap, J. Chou, R. Lewis, C. Hartley, M. Entman, and J.B. Field Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs J. Clin. Invest. 72 1983 590 601
32. A. Beloff-Chain, N. Freund, and K.A. Rookledge Blood glucose and serum insulin levels in lean and genetically obese mice Horm. Metab. Res. 7 1975 374 378