메뉴 건너뛰기




Volumn 8, Issue 1, 2016, Pages 154-165

Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS

Author keywords

AD; Brain tissues; DHA; Fatty acid; GC MS

Indexed keywords

DOCOSAHEXAENOIC ACID; ELAIDIC ACID; ERUCIC ACID; FATTY ACID; FATTY ACID ESTER; HEPTADECANOIC ACID; MYRISTIC ACID; PALMITIC ACID; PALMITOLEIC ACID; PENTADECANOIC ACID; STEARIC ACID;

EID: 84957798218     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (37)

References (51)
  • 1
    • 84968376839 scopus 로고    scopus 로고
    • ARUK, Dementia Statistics, http://www.alzheimersresearchuk.org/dementia-statistics/ 2014.
    • (2014)
  • 3
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer’s disease: An appraisal for the development of therapeutics
    • Karran E, Mercken M and De Strooper B. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 2011; 10: 698-712.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 4
    • 78751644048 scopus 로고    scopus 로고
    • Amyloid-beta and tau--a toxic pas de deux in Alzheimer’s disease
    • Ittner LM and Gotz J. Amyloid-beta and tau--a toxic pas de deux in Alzheimer’s disease. Nat Rev Neurosci 2011; 12: 65-72.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 65-72
    • Ittner, L.M.1    Gotz, J.2
  • 5
    • 84873388502 scopus 로고    scopus 로고
    • Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer’s disease
    • Graham SF, Chevallier OP, Roberts D, Holscher C, Elliott CT and Green BD. Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer’s disease. Anal Chem 2013; 85: 1803-1811.
    • (2013) Anal Chem , vol.85 , pp. 1803-1811
    • Graham, S.F.1    Chevallier, O.P.2    Roberts, D.3    Holscher, C.4    Elliott, C.T.5    Green, B.D.6
  • 6
    • 84896897706 scopus 로고    scopus 로고
    • Lipidomics of Alzheimer’s disease
    • Touboul D and Gaudin M. Lipidomics of Alzheimer’s disease. Bioanalysis 2014; 6: 541-561.
    • (2014) Bioanalysis , vol.6 , pp. 541-561
    • Touboul, D.1    Gaudin, M.2
  • 8
    • 0028885854 scopus 로고
    • GM1 ganglioside-bound amyloid beta-protein (A beta): A possible form of preamyloid in Alzheimer’s disease
    • Yanagisawa K, Odaka A, Suzuki N and Ihara Y. GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer’s disease. Nat Med 1995; 1: 1062-1066.
    • (1995) Nat Med , vol.1 , pp. 1062-1066
    • Yanagisawa, K.1    Odaka, A.2    Suzuki, N.3    Ihara, Y.4
  • 9
    • 0029550974 scopus 로고
    • Inositol trisphosphate and calcium signaling
    • Berridge MJ. Inositol trisphosphate and calcium signaling. Ann N Y Acad Sci 1995; 766: 31-43.
    • (1995) Ann N Y Acad Sci , vol.766 , pp. 31-43
    • Berridge, M.J.1
  • 11
    • 0035980759 scopus 로고    scopus 로고
    • Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
    • Takenawa T and Itoh T. Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim Biophys Acta 2001; 1533: 190-206.
    • (2001) Biochim Biophys Acta , vol.1533 , pp. 190-206
    • Takenawa, T.1    Itoh, T.2
  • 12
    • 2942623783 scopus 로고    scopus 로고
    • Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals
    • Wenk MR and De Camilli P. Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals. Proc Natl Acad Sci U S A 2004; 101: 8262-8269.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8262-8269
    • Wenk, M.R.1    De Camilli, P.2
  • 13
    • 84884316964 scopus 로고    scopus 로고
    • Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions
    • Monteiro JP, Oliveira PJ and Jurado AS. Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions. Prog Lipid Res 2013; 52: 513-528.
    • (2013) Prog Lipid Res , vol.52 , pp. 513-528
    • Monteiro, J.P.1    Oliveira, P.J.2    Jurado, A.S.3
  • 14
    • 84898891503 scopus 로고    scopus 로고
    • Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease
    • Meikle PJ, Wong G, Barlow CK and Kingwell BA. Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease. Pharmacol Ther 2014; 143: 12-23.
    • (2014) Pharmacol Ther , vol.143 , pp. 12-23
    • Meikle, P.J.1    Wong, G.2    Barlow, C.K.3    Kingwell, B.A.4
  • 16
    • 0035023152 scopus 로고    scopus 로고
    • Plasmalogen deficiency in early Alzheimer’s disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry
    • Han X, Holtzman DM and McKeel DW Jr. Plasmalogen deficiency in early Alzheimer’s disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 2001; 77: 1168-1180.
    • (2001) J Neurochem , vol.77 , pp. 1168-1180
    • Han, X.1    Holtzman, D.M.2    McKeel, D.W.3
  • 19
    • 84863254027 scopus 로고    scopus 로고
    • Identification of a new plasma biomarker of Alzheimer’s disease using metabolomics technology
    • Sato Y, Suzuki I, Nakamura T, Bernier F, Aoshima K and Oda Y. Identification of a new plasma biomarker of Alzheimer’s disease using metabolomics technology. J Lipid Res 2012; 53: 567-576.
    • (2012) J Lipid Res , vol.53 , pp. 567-576
    • Sato, Y.1    Suzuki, I.2    Nakamura, T.3    Bernier, F.4    Aoshima, K.5    Oda, Y.6
  • 22
    • 84859498953 scopus 로고    scopus 로고
    • Serum fatty acid profiles using GC-MS and multivariate statistical analysis: Potential biomarkers of Alzheimer’s disease
    • Wang DC, Sun CH, Liu LY, Sun XH, Jin XW, Song WL, Liu XQ and Wan XL. Serum fatty acid profiles using GC-MS and multivariate statistical analysis: potential biomarkers of Alzheimer’s disease. Neurobiol Aging 2012; 33: 1057-1066.
    • (2012) Neurobiol Aging , vol.33 , pp. 1057-1066
    • Wang, D.C.1    Sun, C.H.2    Liu, L.Y.3    Sun, X.H.4    Jin, X.W.5    Song, W.L.6    Liu, X.Q.7    Wan, X.L.8
  • 23
    • 46749151032 scopus 로고    scopus 로고
    • The emerging role of docosahexaenoic acid in neuroinflammation
    • Orr SK and Bazinet RP. The emerging role of docosahexaenoic acid in neuroinflammation. Curr Opin Investig Drugs 2008; 9: 735-743.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 735-743
    • Orr, S.K.1    Bazinet, R.P.2
  • 24
    • 77951975011 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids, neuroinflammation and well being
    • Laye S. Polyunsaturated fatty acids, neuroinflammation and well being. Prostaglandins Leukot Essent Fatty Acids 2010; 82: 295-303.
    • (2010) Prostaglandins Leukot Essent Fatty Acids , vol.82 , pp. 295-303
    • Laye, S.1
  • 25
    • 84922479473 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and their metabolites in brain function and disease
    • Bazinet RP and Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 2014; 15: 771-785.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 771-785
    • Bazinet, R.P.1    Laye, S.2
  • 27
    • 0037452612 scopus 로고    scopus 로고
    • Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion
    • Bagga D, Wang L, Farias-Eisner R, Glaspy JA and Reddy ST. Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci U S A 2003; 100: 1751-1756.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1751-1756
    • Bagga, D.1    Wang, L.2    Farias-Eisner, R.3    Glaspy, J.A.4    Reddy, S.T.5
  • 28
    • 76849108962 scopus 로고    scopus 로고
    • Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer’s disease
    • Fraser T, Tayler H and Love S. Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer’s disease. Neurochem Res 2010; 35: 503-513.
    • (2010) Neurochem Res , vol.35 , pp. 503-513
    • Fraser, T.1    Tayler, H.2    Love, S.3
  • 29
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M and Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226: 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 32
    • 39749122734 scopus 로고    scopus 로고
    • The opposing effects of n-3 and n-6 fatty acids
    • Schmitz G and Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008; 47: 147-155.
    • (2008) Prog Lipid Res , vol.47 , pp. 147-155
    • Schmitz, G.1    Ecker, J.2
  • 33
    • 0034237584 scopus 로고    scopus 로고
    • Essential fatty acids and the brain: Possible health implications
    • Youdim KA, Martin A and Joseph JA. Essential fatty acids and the brain: possible health implications. Int J Dev Neurosci 2000; 18: 383-399.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 383-399
    • Youdim, K.A.1    Martin, A.2    Joseph, J.A.3
  • 34
    • 77953904162 scopus 로고    scopus 로고
    • Fatty acids from fish: The anti-inflammatory potential of long-chain omega-3 fatty acids
    • Wall R, Ross RP, Fitzgerald GF and Stanton C. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev 2010; 68: 280-289.
    • (2010) Nutr Rev , vol.68 , pp. 280-289
    • Wall, R.1    Ross, R.P.2    Fitzgerald, G.F.3    Stanton, C.4
  • 36
    • 33745728329 scopus 로고    scopus 로고
    • Lipoxins and new lipid mediators in the resolution of inflammation
    • Schwab JM and Serhan CN. Lipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol 2006; 6: 414-420.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 414-420
    • Schwab, J.M.1    Serhan, C.N.2
  • 37
    • 0037152160 scopus 로고    scopus 로고
    • Resolvins: A family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    • Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G and Moussignac RL. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 2002; 196: 1025-1037.
    • (2002) J Exp Med , vol.196 , pp. 1025-1037
    • Serhan, C.N.1    Hong, S.2    Gronert, K.3    Colgan, S.P.4    Devchand, P.R.5    Mirick, G.6    Moussignac, R.L.7
  • 41
    • 77953279191 scopus 로고    scopus 로고
    • Phospholipase A2 and arachidonic acid in Alzheimer’s disease
    • Sanchez-Mejia RO and Mucke L. Phospholipase A2 and arachidonic acid in Alzheimer’s disease. Biochim Biophys Acta 2010; 1801: 784-790.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 784-790
    • Sanchez-Mejia, R.O.1    Mucke, L.2
  • 42
    • 12344253802 scopus 로고    scopus 로고
    • Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers
    • Serhan CN, Arita M, Hong S and Gotlinger K. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 2004; 39: 1125-1132.
    • (2004) Lipids , vol.39 , pp. 1125-1132
    • Serhan, C.N.1    Arita, M.2    Hong, S.3    Gotlinger, K.4
  • 43
    • 0037051533 scopus 로고    scopus 로고
    • Antioxidant and cyclooxygenase activities of fatty acids found in food
    • Henry GE, Momin RA, Nair MG and Dewitt DL. Antioxidant and cyclooxygenase activities of fatty acids found in food. J Agric Food Chem 2002; 50: 2231-2234.
    • (2002) J Agric Food Chem , vol.50 , pp. 2231-2234
    • Henry, G.E.1    Momin, R.A.2    Nair, M.G.3    Dewitt, D.L.4
  • 45
    • 79251559674 scopus 로고    scopus 로고
    • Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase-and PPARgammamediated mechanisms in Alzheimer’s disease models
    • Zhao Y, Calon F, Julien C, Winkler JW, Petasis NA, Lukiw WJ and Bazan NG. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase-and PPARgammamediated mechanisms in Alzheimer’s disease models. PLoS One 2011; 6: e15816.
    • (2011) Plos One , vol.6
    • Zhao, Y.1    Calon, F.2    Julien, C.3    Winkler, J.W.4    Petasis, N.A.5    Lukiw, W.J.6    Bazan, N.G.7
  • 47
    • 0038013967 scopus 로고    scopus 로고
    • Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation
    • Hong S, Gronert K, Devchand PR, Moussignac RL and Serhan CN. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 2003; 278: 14677-14687.
    • (2003) J Biol Chem , vol.278 , pp. 14677-14687
    • Hong, S.1    Gronert, K.2    Devchand, P.R.3    Moussignac, R.L.4    Serhan, C.N.5
  • 48
    • 0347122965 scopus 로고    scopus 로고
    • Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
    • Lee JT, Xu J, Lee JM, Ku G, Han X, Yang DI, Chen S and Hsu CY. Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J Cell Biol 2004; 164: 123-131.
    • (2004) J Cell Biol , vol.164 , pp. 123-131
    • Lee, J.T.1    Xu, J.2    Lee, J.M.3    Ku, G.4    Han, X.5    Yang, D.I.6    Chen, S.7    Hsu, C.Y.8
  • 50
    • 20644467041 scopus 로고    scopus 로고
    • Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons
    • Patil S and Chan C. Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett 2005; 384: 288-293.
    • (2005) Neurosci Lett , vol.384 , pp. 288-293
    • Patil, S.1    Chan, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.