Serum fatty acid profiles using GC-MS and multivariate statistical analysis: Potential biomarkers of Alzheimer's disease

Neurobiology of Aging

Volumn 33, Issue 6, 2012, Pages 1057-1066

  Wang, De Cai ^a   Sun, Chang Hao ^a   Liu, Li Yan ^a   Sun, Xiao Hong ^a   Jin, Xin Wen ^a   Song, Wen Lei ^a   Liu, Xiu Qin ^a   Wan, Xue Lian ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Biomarker; Free fatty acid; GC MS; Partial least squares discriminant analysis (PLS DA)

Indexed keywords

11,14 EICOSADIENOIC ACID; 5,8,11,14,17 ICOSAPENTAENOIC ACID; 7,10,13,16,19 DOCOSAPENTAENOIC ACID; ARACHIDONIC ACID; BIOLOGICAL MARKER; CERVONIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; DONEPEZIL; FATTY ACID; GAMMA LINOLENIC ACID; HEPTADECANOIC ACID; LIGNOCERIC ACID; LINOLEIC ACID; LINOLENIC ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; RIVASTIGMINE; SATURATED FATTY ACID; SELACHOLEIC ACID; STEARIC ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; MALE; MASS FRAGMENTOGRAPHY; MULTIVARIATE ANALYSIS; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS;

EID: 84859498953     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2010.09.013     Document Type: Article

References (51)

1. Anderson G.J., Connor W.E., Corliss J.D. Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retian. Pediatr. Res 1990, 27:89-97.
2. Balazs L., Leon M. Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem. Res 1994, 19:1131-1137.
3. Barberger-Gateau P., Raffaitin C., Letenneur L., Berr C., Tzourio C., Dartigues J.F., Alpérovitch A. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology 2007, 69:1921-1930.
4. Bogdanov M., Matson W.R., Wang L., Matson T., Saunders-Pullman R., Bressman S.S., Flint Beal M. Metabolomic profiling to develop blood biomarkers for Parkinson's disease. Brain 2008, 131:389-396.
5. Craft S., Asthana S., Schellenberg G., Cherrier M., Baker L.D., Newcomer J., Plymate S., Latendresse S., Petrova A., Raskind M., Peskind E., Lofgreen C., Grimwood K. Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology 1999, 70:146-152.
6. Conquer J.A., Tierney M.C., Zecevic J., Bettger W.J., Fisher R.H. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 2000, 35:1305-1312.
7. Claudino W.M., Quattrone A., Biganzoli L., Pestrin M., Bertini I., Di Leo A. Metabolomics: available results, current research projects in breast cancer and future applications. J. Clin. Oncol 2007, 25:2840-2846.
8. de La Torre J.C. Alzheimer's disease: how does it start?. J. Alzheimers Dis 2002, 4:497-512.
9. de La Torre J.C. Vascular basis of Alzheimer's pathogenesis. Ann. N. Y. Acad. Sci 2002, 977:196-215.
10. de La Torre J.C. Alzheimer's disease is a vasocognopathy: a new term to describe its nature. Neurol. Res 2004, 26:517-524.
11. Eriksson L., Johansson E., Kettaneh-Wold N. Multi-and megavariate data analysis-Part. 1: Basic principles and applications 2001, Umetrics AB, Umea. 2nd ed.
12. Fiehn O. Combining genomics, metabolome analysis, and biochemical modeling to understand metabolic networks. Comp. Funct. Genomics 2001, 2:155-168.
13. Goux W.J., Rodriguez S., Sparkman D.R. Analysis of the core components of Alzheimer paired helical filaments-A gas chromatography/mass spectrometry characterization of fatty acids, carbohydrates and long-chain bases. FEBS Lett 1995, 366:81-85.
14. Green K.N., Martinez-Coria H., Khashwji H., Hall E.B., Yurko-Mauro K.A., Ellis L., LaFerla F.M. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-{beta} and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci 2007, 27:4385-4395.
15. Guérin O., Andrieu S., Schneider S.M., Cortes F., Cantet C., Gillette-Guyonnet S., Vellas B. Characteristics of Alzheimer's disease patients with a rapid weight loss during a six-year follow-up. Clin. Nutr 2009, 28:141-146.
16. Horrocks L.A., Yeo Y.K. Health benefits of docosahexaenoic acid (DHA). Pharmacol. Res 1999, 40:211-225.
17. Hebert L.E., Scherr P.A., Bienias J.L., Bennett D.A., Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol 2003, 8:1119-1122.
18. Heinemann K.M., Bauer J.E. Docosahexaenoic acid and neurologic development in animals. J. Am. Vet. Med. Assoc 2006, 228:700-705.
19. Ikemoto A., Ohishi M., Sato Y., Hata N., Misawa Y., Fujii Y., Okuyama H. Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. J. Lipid Res 2001, 42:1655-1663.
20. Innis S.M. Dietary (n-3) Fatty Acids and Brain Development. J. Nutr 2007, 137:855-859.
21. Kyle D.J., Schaefer E., Patton G., Beiser A. Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids 1999, 34:S245.
22. Kivipelto M., Solomon A. Cholesterol as a risk factor for Alzheimer's disease-epidemiological evidence. Acta Neurol. Scand. Suppl 2006, 185:50-57.
23. Lukiw W.J., Cui J.G., Marcheselli V.L., Bodker M., Botkjaer A., Gotlinger K., Serhan C.N., Bazan N.G. A role for docosahexaenoic acid derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J. Clin. Invest 2005, 115:2774-2783.
24. Lim G.P., Calon F., Morihara T., Yang F., Teter B., Ubeda O., Salem N., Frautschy S.A., Cole G.M. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci 2005, 12:3032-3040.
25. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
26. Morris M.C., Evans D.A., Bienias J.L., Tangney C.C., Bennett D.A., Wilson R.S., Aggarwal N., Schneider J. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch. Neurol 2003, 60:940-946.
27. Maclean C.H., Issa A.M., Newberry S.J., Mojica W.A., Morton S.C., Garland R.H., Hilton L.G., Traina S.B., Shekelle P.G. Effects of omega-3 fatty acids on cognitive function with aging, dementia, and neurological diseases. Evid Rep Technol Assess (Summ) 2005, 1-88.
28. Mariani E., Polidori M.C., Cherubini A., Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J. Chromatogr. B Anal. Technol. Biomed. Life Sci 2005, 827:65-75.
29. Marszalek J.R., Lodish H.F. Docosahexanoic acid, fatty acid-interacting proteins and neuronal function: breastmilk and fish are good for you. Annu. Rev. Cell Dev. Biol 2005, 21:633-657.
30. Migliore L., Fontana I., Colognato R., Coppede F., Siciliano G., Murri L. Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases. Neurobiol. Aging 2005, 26:587-595.
31. Nurk E., Drevon C.A., Refsum H., Solvoll K., Vollset S.E., Nygård O., Nygaard H.A., Engedal K., Tell G.S., Smith A.D. Cognitive performance among the elderly and dietary fish intake: the Hordal and Health Study. Am. J. Clin. Nutr. 2007, 86:1470-1478.
32. Nourhashémi F., Vellas B. Weight loss as a predictor of dementia and Alzheimer's disease?. Expert Rev. Neurother 2008, 8:691-693.
33. Pettegrew J.W., Panchalingam K., Klunk W.E., McClure R.J., Muenz L.R. Alterations of cerebral metabolism in probable Alzheimer's disease: a preliminary study. Neurobiol. Aging 1994, 15:117-132.
34. Praticò D., Clark C.M., Liun F., Rokach J., Lee V.Y., Trojanowski J.Q. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol 2002, 59:972-976.
35. Paik M.J., Lee S., Cho K.H., Kim K.R. Urinary polyamines and N-acetylated polyamines in four patients with Alzheimer's disease as their N-ethoxycarbonyl-N-pentafluoropropionyl derivatives by gas chromatography-mass spectrometry in selected ion monitoring mode. Anal. Chim. Acta 2006, 576:55-60.
36. Ramanadham S., Hsu F.F., Bohrer A., Nowatzke W., Ma Z., Turk J. Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis. Biochemistry 1998, 37:4553-4567.
37. Roberts L.J., Montine T.J., Markesbery W.R., Tapper A.R., Hardy P., Chemtob S., Dettbarn W.D., Morrow J.D. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J. Biol. Chem 1998, 273:13605-13612.
38. Ramanadham S., Hsu F.F., Zhang S., Bohrer A., Ma Z., Turk J. Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion. Biochim. Biophys. Acta 2000, 1484:251-266.
39. Soderberg M., Edlund C., Kristensson K., Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 1991, 26:421-425.
40. Small G.W., Rabins P.V., Barry P.P., Buckholtz N.S., DeKosky S.T., Ferris S.H., Finkel S.I., Gwyther L.P., Khachaturian Z.S., Lebowitz B.D., McRae T.D., Morris J.C., Oakley F., Schneider L.S., Streim J.E., Sunderland T., Teri L.A., Tune L.E. Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. JAMA 1997, 16:1363-1371.
41. Shobab L.A., Hsiung G.Y., Feldman H.H. Cholesterol in Alzheimer's disease. Lancet Neurol 2005, 4:841-852.
42. Schaefer E.J., Bongard V., Beiser A.S., Lamon-Fava S., Robins S.J., Au R., Tucker K.L., Kyle D.J., Wilson P.W., Wolf P.A. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch. Neurol 2006, 63:1545-1550.
43. Uauy R., Dangour A.D. Nutrition in brain development and aging: role of essential fatty acids. Nutr. Rev 2006, 64:S24-S33. Discussion, S72-S91.
44. Wold S., Boye E., Slater S., Kleckner N., Skarstad K. Effects of purified SeqA protein on oriC-dependent DNA replication in vitro. EMBO J 1998, 44:4158-4165.
45. Wang H.L., Yu X. The prevalence of Alzheimer's disease in China. Chin. J. Gen. Pract 2006, 5:358-360.
46. Wikoff W.R., Gangoiti J.A., Barshop B.A., Siuzdak G. Metabolomics identifies perturbations in human disorders of propionate metabolism. Clin. Chem 2007, 53:2169-2176.
47. Xue R., Lin Z., Deng C., Dong L., Liu T., Wang J., Shen X. A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry. Rapid Commun. Mass Spectrom 2008, 22:3061-3068.
48. Yang J., Xu G., Hong Q., Liebich H.M., Lutz k., Schmülling R.M., Wahl H.G. Discrimination of Type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles. J. Chromatogr. B Anal. Technol. Biomed. Life Sci 2004, 813:53-58.
49. Yi L.Z., He J., Liang Y.Z., Yuan D.L., Chau F.U. Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA. FEBS Lett 2006, 580:6837-6845.
50. Zhang Z.X., Zahner G.E., Román G.C., Liu J., Hong Z., Qu Q.M., Liu X.H., Zhang X.J., Zhou B., Wu C.B., Tang M.N., Hong X., Li H. Dementia subtypes in China: prevalence in Beijing, Xi'an, Shanghai, and Chengdu. Arch. Neurol 2005, 62:447-453.
51. Zeisel S.H. Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am. J. Clin. Nutr 2007, 86:542-548.