Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase

Stem Cell Research

Volumn 10, Issue 2, 2013, Pages 257-266

  Yuan, Qiuhuan ^a   Zhao, Shidou ^b   Wang, Fuwu ^a   Zhang, Hui ^a   Chen, Zi Jiang ^b   Wang, Juntao ^c   Wang, Zhen ^a   Du, Zhaoxia ^a   Ling, Eng Ang ^d   Liu, Qian ^a   Hao, Aijun ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; PALMITIC ACID; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; NEURAL STEM CELLS; PALMITIC ACID; TIME FACTORS;

EID: 84872400077     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2012.11.008     Document Type: Article

References (41)

1. Adibhatla R.M., Hatcher J.F. Altered lipid metabolism in brain injury and disorders. Subcell. Biochem. 2008, 49:241-268.
2. Almaguel F.G., Liu J.W., et al. Activation and reversal of lipotoxicity in PC12 and rat cortical cells following exposure to palmitic acid. J. Neurosci. Res. 2009, 87:1207-1218.
3. Alvarez-Buylla A., Seri B., et al. Identification of neural stem cells in the adult vertebrate brain. Brain Res. Bull. 2002, 57:751-758.
4. Anthony B., Zhou F.C., et al. Alcohol exposure alters cell cycle and apoptotic events during early neurulation. Alcohol Alcohol. 2008, 43:261-273.
5. Boden G. Obesity and free fatty acids. Endocrinol. Metab. Clin. N. Am. 2008, 37:635-646. (viii-ix).
6. Boden G., She P., et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 2005, 54:3458-3465.
7. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J. Cell Mol. Med. 2003, 7:249-257.
8. Chai W., Liu Z. p38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor-kappaB degradation in human coronary artery endothelial cells. Endocrinology 2007, 148:1622-1628.
9. Coulthard L.R., White D.E., et al. p38 (MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol. Med. 2009, 15:369-379.
10. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103:239-252.
11. Elahi M.M., Cagampang F.R., et al. Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br. J. Nutr. 2009, 102:514-519.
12. Farooqui A.A., Horrocks L.A. Lipid peroxides in the free radical pathophysiology of brain diseases. Cell. Mol. Neurobiol. 1998, 18:599-608.
13. Fike J.R. Physiopathology of radiation-induced neurotoxicity. Rev. Neurol. (Paris) 2011, 167:746-750.
14. Gao Q., Gao Y.M. Hyperglycemic condition disturbs the proliferation and cell death of neural progenitors in mouse embryonic spinal cord. Int. J. Dev. Neurosci. 2007, 25:349-357.
15. Gomez-Lechon M.J., Donato M.T., et al. A human hepatocellular in vitro model to investigate steatosis. Chem. Biol. Interact. 2007, 165:106-116.
16. Hotamisligil G.S. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 2005, 54(Suppl. 2):S73-S78.
17. Jiang H., Liang C., et al. Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Atherosclerosis 2010, 210:71-77.
18. Kim S.U. Human neural stem cells genetically modified for brain repair in neurological disorders. Neuropathology 2004, 24:159-171.
19. Kim E.K., Choi E.J. Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta 2010, 1802:396-405.
20. Korsmeyer S.J., Shutter J.R., et al. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer Biol. 1993, 4:327-332.
21. Kourtidis A., Srinivasaiah R., et al. Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity. Breast Cancer Res. 2009, 11:R16.
22. Lee J.Y., Sohn K.H., et al. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 2001, 276:16683-16689.
23. Lindqvist A., Mohapel P., et al. High-fat diet impairs hippocampal neurogenesis in male rats. Eur. J. Neurol. 2006, 13:1385-1388.
24. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79:1431-1568.
25. Malhi H., Bronk S.F., et al. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 2006, 281:12093-12101.
26. Miles J.M., Nelson R.H. Contribution of triglyceride-rich lipoproteins to plasma free fatty acids. Horm. Metab. Res. 2007, 39:726-729.
27. Mittendorfer B. Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14:535-541.
28. Patil S., Sheng L., et al. Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons. Neurosci. Lett. 2006, 406:55-59.
29. Patil S., Melrose J., et al. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Eur. J. Neurosci. 2007, 26:2131-2141.
30. Patil S., Balu D., et al. Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease. BMC Res. Notes 2008, 1:20.
31. Porter A.G., Janicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999, 6:99-104.
32. Ricchi M., Odoardi M.R., et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J. Gastroenterol. Hepatol. 2009, 24:830-840.
33. Saunders J., Mathewkutty S., et al. Cardiomyopathy in type 2 diabetes: update on pathophysiological mechanisms. Herz 2008, 33:184-190.
34. Temple S. The development of neural stem cells. Nature 2001, 414:112-117.
35. Tesone-Coelho C., Varela P., et al. Effects of ethanol on hippocampal neurogenesis depend on the conditioned appetitive response. Addict. Biol. 2012, 10.1111/j.1369-1600.2011.00434.x.
36. Tozuka Y., Wada E., et al. Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring. FASEB J. 2009, 23:1920-1934.
37. Ulloth J.E., Casiano C.A., et al. Palmitic and stearic fatty acids induce caspase-dependent and -independent cell death in nerve growth factor differentiated PC12 cells. J. Neurochem. 2003, 84:655-668.
38. Wang S.W., Wang M., et al. Effects of dietary fat on food intake and brain uptake and oxidation of fatty acids. Physiol. Behav. 1994, 56:517-522.
39. Wang W., Zhang D., et al. Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line. Regul. Pept. 2010, 161:43-50.
40. Welters H.J., Diakogiannaki E., et al. Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate. Apoptosis 2006, 11:1231-1238.
41. Yu H., Bi Y., et al. Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice. Int. J. Dev. Neurosci. 2009, 28:271-276.