메뉴 건너뛰기




Volumn 13, Issue 1, 2016, Pages

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

Author keywords

Alzheimers; BBB; Chemokine; Cytokine; IL 6; Inflammation; MMP 2; NOX4; Phagocytosis; SMAD2 3

Indexed keywords

ALAMAR BLUE; CD36 ANTIGEN; CD47 ANTIGEN; CD68 ANTIGEN; CYCLOOXYGENASE 2; DYE; FRACTALKINE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SCAVENGER RECEPTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; CONDITIONED MEDIUM; CYTOKINE; NOX4 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 84957704766     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0503-0     Document Type: Article
Times cited : (146)

References (108)
  • 1
    • 57349100348 scopus 로고    scopus 로고
    • Brain inflammation initiates seizures
    • Kleen JK, Holmes GL. Brain inflammation initiates seizures. Nat Med. 2008;14(12):1309-10.
    • (2008) Nat Med , vol.14 , Issue.12 , pp. 1309-1310
    • Kleen, J.K.1    Holmes, G.L.2
  • 3
    • 0033979993 scopus 로고    scopus 로고
    • Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
    • del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 2000;10(1):95-112.
    • (2000) Brain Pathol , vol.10 , Issue.1 , pp. 95-112
    • Zoppo, G.1    Ginis, I.2    Hallenbeck, J.M.3    Iadecola, C.4    Wang, X.5    Feuerstein, G.Z.6
  • 4
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140(6):918-34.
    • (2010) Cell , vol.140 , Issue.6 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 5
    • 84884246344 scopus 로고    scopus 로고
    • Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain
    • Ramesh G, MacLean AG, Philipp MT. Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain. Mediators Inflamm. 2013;2013:480739.
    • (2013) Mediators Inflamm , vol.2013 , pp. 480739
    • Ramesh, G.1    MacLean, A.G.2    Philipp, M.T.3
  • 6
    • 33750591957 scopus 로고    scopus 로고
    • Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology
    • Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, et al. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest. 2006;116(11):3060-9.
    • (2006) J Clin Invest , vol.116 , Issue.11 , pp. 3060-3069
    • Tesseur, I.1    Zou, K.2    Esposito, L.3    Bard, F.4    Berber, E.5    Can, J.V.6
  • 7
    • 0028230259 scopus 로고
    • Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat
    • Logan A, Berry M, Gonzalez AM, Frautschy SA, Sporn MB, Baird A. Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur J Neurosci. 1994;6(3):355-63.
    • (1994) Eur J Neurosci , vol.6 , Issue.3 , pp. 355-363
    • Logan, A.1    Berry, M.2    Gonzalez, A.M.3    Frautschy, S.A.4    Sporn, M.B.5    Baird, A.6
  • 8
    • 0026510668 scopus 로고
    • Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation
    • Lindholm D, Castren E, Kiefer R, Zafra F, Thoenen H. Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol. 1992;117(2):395-400.
    • (1992) J Cell Biol , vol.117 , Issue.2 , pp. 395-400
    • Lindholm, D.1    Castren, E.2    Kiefer, R.3    Zafra, F.4    Thoenen, H.5
  • 9
    • 42649120343 scopus 로고    scopus 로고
    • Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    • Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, et al. Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell. 2008;2(5):472-83.
    • (2008) Cell Stem Cell , vol.2 , Issue.5 , pp. 472-483
    • Falk, S.1    Wurdak, H.2    Ittner, L.M.3    Ille, F.4    Sumara, G.5    Schmid, M.T.6
  • 10
    • 0344013136 scopus 로고    scopus 로고
    • TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes
    • Paglinawan R, Malipiero U, Schlapbach R, Frei K, Reith W, Fontana A. TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes. Glia. 2003;44(3):219-31.
    • (2003) Glia , vol.44 , Issue.3 , pp. 219-231
    • Paglinawan, R.1    Malipiero, U.2    Schlapbach, R.3    Frei, K.4    Reith, W.5    Fontana, A.6
  • 11
    • 0028073808 scopus 로고
    • Differential modulation of astrocyte cytokine gene expression by TGF-beta
    • Benveniste EN, Kwon J, Chung WJ, Sampson J, Pandya K, Tang LP. Differential modulation of astrocyte cytokine gene expression by TGF-beta. J Immunol. 1994;153(11):5210-21.
    • (1994) J Immunol , vol.153 , Issue.11 , pp. 5210-5221
    • Benveniste, E.N.1    Kwon, J.2    Chung, W.J.3    Sampson, J.4    Pandya, K.5    Tang, L.P.6
  • 12
    • 0028967734 scopus 로고
    • Tumor necrosis factor alpha and transforming growth factor beta upregulate astrocyte expression of monocyte chemoattractant protein-1
    • Hurwitz AA, Lyman WD, Berman JW. Tumor necrosis factor alpha and transforming growth factor beta upregulate astrocyte expression of monocyte chemoattractant protein-1. J Neuroimmunol. 1995;57(1-2):193-8.
    • (1995) J Neuroimmunol , vol.57 , Issue.1-2 , pp. 193-198
    • Hurwitz, A.A.1    Lyman, W.D.2    Berman, J.W.3
  • 13
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGF-beta signal transduction
    • Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci. 2001;114(Pt 24):4359-69.
    • (2001) J Cell Sci , vol.114 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 14
    • 0025310993 scopus 로고
    • Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system
    • Sato Y, Tsuboi R, Lyons R, Moses H, Rifkin DB. Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J Cell Biol. 1990;111(2):757-63.
    • (1990) J Cell Biol , vol.111 , Issue.2 , pp. 757-763
    • Sato, Y.1    Tsuboi, R.2    Lyons, R.3    Moses, H.4    Rifkin, D.B.5
  • 15
    • 0001505189 scopus 로고
    • An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes
    • Antonelli-Orlidge A, Saunders KB, Smith SR, D'Amore PA. An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci U S A. 1989;86(12):4544-8.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.12 , pp. 4544-4548
    • Antonelli-Orlidge, A.1    Saunders, K.B.2    Smith, S.R.3    D'Amore, P.A.4
  • 16
    • 0027212063 scopus 로고
    • TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration
    • Morgan TE, Nichols NR, Pasinetti GM, Finch CE. TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration. Exp Neurol. 1993;120(2):291-301.
    • (1993) Exp Neurol , vol.120 , Issue.2 , pp. 291-301
    • Morgan, T.E.1    Nichols, N.R.2    Pasinetti, G.M.3    Finch, C.E.4
  • 17
    • 0028329252 scopus 로고
    • Neuronal rescue with transforming growth factor-[beta] 1 after hypoxic-ischaemic brain injury
    • McNeill H, Williams C, Guan J, Dragunow M, Lawlor P, Sirimanne E, et al. Neuronal rescue with transforming growth factor-[beta] 1 after hypoxic-ischaemic brain injury. Neuroreport. 1994;5(8):901-4.
    • (1994) Neuroreport , vol.5 , Issue.8 , pp. 901-904
    • McNeill, H.1    Williams, C.2    Guan, J.3    Dragunow, M.4    Lawlor, P.5    Sirimanne, E.6
  • 18
    • 0026437599 scopus 로고
    • Synthesis of TGF-beta 1 by vascular endothelial cells is correlated with cell spreading
    • Merrilees MJ, Sodek J. Synthesis of TGF-beta 1 by vascular endothelial cells is correlated with cell spreading. J Vasc Res. 1992;29(5):376-84.
    • (1992) J Vasc Res , vol.29 , Issue.5 , pp. 376-384
    • Merrilees, M.J.1    Sodek, J.2
  • 19
    • 84867530190 scopus 로고    scopus 로고
    • TGF beta signaling and its role in glioma pathogenesis
    • Kaminska B, Kocyk M, Kijewska M. TGF beta signaling and its role in glioma pathogenesis. Adv Exp Med Biol. 2013;986:171-87.
    • (2013) Adv Exp Med Biol , vol.986 , pp. 171-187
    • Kaminska, B.1    Kocyk, M.2    Kijewska, M.3
  • 20
    • 38949165993 scopus 로고    scopus 로고
    • Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor
    • Wesolowska A, Kwiatkowska A, Slomnicki L, Dembinski M, Master A, Sliwa M, et al. Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. Oncogene. 2008;27(7):918-30.
    • (2008) Oncogene , vol.27 , Issue.7 , pp. 918-930
    • Wesolowska, A.1    Kwiatkowska, A.2    Slomnicki, L.3    Dembinski, M.4    Master, A.5    Sliwa, M.6
  • 21
    • 0029879741 scopus 로고    scopus 로고
    • Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans
    • Krupinski J, Kumar P, Kumar S, Kaluza J. Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans. Stroke. 1996;27(5):852-7.
    • (1996) Stroke , vol.27 , Issue.5 , pp. 852-857
    • Krupinski, J.1    Kumar, P.2    Kumar, S.3    Kaluza, J.4
  • 22
    • 84879390394 scopus 로고    scopus 로고
    • Serum concentrations of transforming growth factor-Beta 1 in predicting the occurrence of diabetic retinopathy in juvenile patients with type 1 diabetes mellitus
    • Zorena K, Malinowska E, Raczynska D, Mysliwiec M, Raczynska K. Serum concentrations of transforming growth factor-Beta 1 in predicting the occurrence of diabetic retinopathy in juvenile patients with type 1 diabetes mellitus. J Diabetes Res. 2013;2013:614908.
    • (2013) J Diabetes Res , vol.2013 , pp. 614908
    • Zorena, K.1    Malinowska, E.2    Raczynska, D.3    Mysliwiec, M.4    Raczynska, K.5
  • 25
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    • Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76(2):77-98.
    • (2005) Prog Neurobiol , vol.76 , Issue.2 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 26
    • 0029956457 scopus 로고    scopus 로고
    • Regulation of microglial activation by TGF-beta, IL-10, and CSF-1
    • Lodge PA, Sriram S. Regulation of microglial activation by TGF-beta, IL-10, and CSF-1. J Leukoc Biol. 1996;60(4):502-8.
    • (1996) J Leukoc Biol , vol.60 , Issue.4 , pp. 502-508
    • Lodge, P.A.1    Sriram, S.2
  • 27
    • 84891959070 scopus 로고    scopus 로고
    • Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFbeta1 or M-CSF
    • Smith AM, Graham ES, Feng SX, Oldfield RL, Bergin PM, Mee EW, et al. Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFbeta1 or M-CSF. PLoS One. 2013;8(12), e80463.
    • (2013) PLoS One , vol.8 , Issue.12
    • Smith, A.M.1    Graham, E.S.2    Feng, S.X.3    Oldfield, R.L.4    Bergin, P.M.5    Mee, E.W.6
  • 28
    • 0347362913 scopus 로고    scopus 로고
    • Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain
    • Brionne TC, Tesseur I, Masliah E, Wyss-Coray T. Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron. 2003;40(6):1133-45.
    • (2003) Neuron , vol.40 , Issue.6 , pp. 1133-1145
    • Brionne, T.C.1    Tesseur, I.2    Masliah, E.3    Wyss-Coray, T.4
  • 29
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, et al. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med. 2001;7(5):612-8.
    • (2001) Nat Med , vol.7 , Issue.5 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6
  • 30
    • 84903610889 scopus 로고    scopus 로고
    • Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system toxoplasma infection
    • Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, et al. Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system toxoplasma infection. J Immunol. 2014;193(1):139-49.
    • (2014) J Immunol , vol.193 , Issue.1 , pp. 139-149
    • Cekanaviciute, E.1    Dietrich, H.K.2    Axtell, R.C.3    Williams, A.M.4    Egusquiza, R.5    Wai, K.M.6
  • 31
    • 0033900999 scopus 로고    scopus 로고
    • Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice
    • Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E. Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am J Pathol. 2000;156(1):139-50.
    • (2000) Am J Pathol , vol.156 , Issue.1 , pp. 139-150
    • Wyss-Coray, T.1    Lin, C.2    Sanan, D.A.3    Mucke, L.4    Masliah, E.5
  • 32
    • 84969442236 scopus 로고    scopus 로고
    • Studying human brain inflammation in leptomeningeal and choroid plexus explant cultures.
    • Dragunow M, Feng S, Rustenhoven J, Curtis M, Faull R. Studying human brain inflammation in leptomeningeal and choroid plexus explant cultures. Neurochemi Res. 2015;1-10.
    • (2015) Neurochemi Res. , pp. 1-10
    • Dragunow, M.1    Feng, S.2    Rustenhoven, J.3    Curtis, M.4    Faull, R.5
  • 33
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification
    • Guillemin GJ, Brew BJ. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol. 2004;75(3):388-97.
    • (2004) J Leukoc Biol , vol.75 , Issue.3 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 34
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010;468(7323):562-6.
    • (2010) Nature , vol.468 , Issue.7323 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 35
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik A, Genove G, Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell. 2011;21(2):193-215.
    • (2011) Dev Cell , vol.21 , Issue.2 , pp. 193-215
    • Armulik, A.1    Genove, G.2    Betsholtz, C.3
  • 38
    • 84894459903 scopus 로고    scopus 로고
    • Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro.
    • Pieper C, Marek JJ, Unterberg M, Schwerdtle T, Galla HJ. Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro. Brain Res. 2014;1550:1-8.
    • (2014) Brain Res. , vol.1550 , pp. 1-8
    • Pieper, C.1    Marek, J.J.2    Unterberg, M.3    Schwerdtle, T.4    Galla, H.J.5
  • 39
    • 80053929920 scopus 로고    scopus 로고
    • Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide
    • Kovac A, Erickson MA, Banks WA. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation. 2011;8:139.
    • (2011) J Neuroinflammation , vol.8 , pp. 139
    • Kovac, A.1    Erickson, M.A.2    Banks, W.A.3
  • 40
    • 84969437125 scopus 로고    scopus 로고
    • Lipopolysaccharide activates TLR4-mediated NF-kappaB signaling pathway and proinflammatory response in human pericytes.
    • Guijarro-Munoz I, Compte M, Alvarez-Cienfuegos A, Alvarez-Vallina L, Sanz L. Lipopolysaccharide activates TLR4-mediated NF-kappaB signaling pathway and proinflammatory response in human pericytes. J Biol Chem. 2013.
    • (2013) J Biol Chem.
    • Guijarro-Munoz, I.1    Compte, M.2    Alvarez-Cienfuegos, A.3    Alvarez-Vallina, L.4    Sanz, L.5
  • 41
    • 0030250260 scopus 로고    scopus 로고
    • CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2
    • Balabanov R, Washington R, Wagnerova J, Dore-Duffy P. CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2. Microvasc Res. 1996;52(2):127-42.
    • (1996) Microvasc Res , vol.52 , Issue.2 , pp. 127-142
    • Balabanov, R.1    Washington, R.2    Wagnerova, J.3    Dore-Duffy, P.4
  • 43
    • 84871300122 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis
    • Wu CF, Chiang WC, Lai CF, Chang FC, Chen YT, Chou YH, et al. Transforming growth factor beta-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis. Am J Pathol. 2013;182(1):118-31.
    • (2013) Am J Pathol , vol.182 , Issue.1 , pp. 118-131
    • Wu, C.F.1    Chiang, W.C.2    Lai, C.F.3    Chang, F.C.4    Chen, Y.T.5    Chou, Y.H.6
  • 44
    • 0242509935 scopus 로고    scopus 로고
    • TGF-beta 1 signaling controls retinal pericyte contractile protein expression
    • Sieczkiewicz GJ, Herman IM. TGF-beta 1 signaling controls retinal pericyte contractile protein expression. Microvasc Res. 2003;66(3):190-6.
    • (2003) Microvasc Res , vol.66 , Issue.3 , pp. 190-196
    • Sieczkiewicz, G.J.1    Herman, I.M.2
  • 46
    • 84937215115 scopus 로고    scopus 로고
    • Pro-inflammatory TNFaα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells
    • O'Carroll SJ, Kho DT, Wiltshire R, Nelson V, Rotimi O, Johnson R, et al. Pro-inflammatory TNFaα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. J Neuroinflammation. 2015;12(1):131.
    • (2015) J Neuroinflammation , vol.12 , Issue.1 , pp. 131
    • O'Carroll, S.J.1    Kho, D.T.2    Wiltshire, R.3    Nelson, V.4    Rotimi, O.5    Johnson, R.6
  • 47
    • 79953657142 scopus 로고    scopus 로고
    • Phagocytic clearance in neurodegeneration
    • Sokolowski JD, Mandell JW. Phagocytic clearance in neurodegeneration. Am J Pathol. 2011;178(4):1416-28.
    • (2011) Am J Pathol , vol.178 , Issue.4 , pp. 1416-1428
    • Sokolowski, J.D.1    Mandell, J.W.2
  • 48
    • 84874650512 scopus 로고    scopus 로고
    • Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE
    • Jones RS, Minogue AM, Connor TJ, Lynch MA. Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE. J Neuroimmune Pharmacol. 2013;8(1):301-11.
    • (2013) J Neuroimmune Pharmacol , vol.8 , Issue.1 , pp. 301-311
    • Jones, R.S.1    Minogue, A.M.2    Connor, T.J.3    Lynch, M.A.4
  • 49
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor
    • Paresce DM, Ghosh RN, Maxfield FR. Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor. Neuron. 1996;17(3):553-65.
    • (1996) Neuron , vol.17 , Issue.3 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 50
    • 84904370000 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation.
    • Matsumoto J, Takata F, Machida T, Takahashi H, Soejima Y, Funakoshi M et al. Tumor necrosis factor-alpha-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation. Neurosci Lett. 2014;578:133-8.
    • (2014) Neurosci Lett. , vol.578 , pp. 133-138
    • Matsumoto, J.1    Takata, F.2    Machida, T.3    Takahashi, H.4    Soejima, Y.5    Funakoshi, M.6
  • 51
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials
    • Gadient RA, Otten UH. Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials. Prog Neurobiol. 1997;52(5):379-90.
    • (1997) Prog Neurobiol , vol.52 , Issue.5 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 52
    • 0033557201 scopus 로고    scopus 로고
    • Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice
    • Penkowa M, Moos T, Carrasco J, Hadberg H, Molinero A, Bluethmann H, et al. Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice. Glia. 1999;25(4):343-57.
    • (1999) Glia , vol.25 , Issue.4 , pp. 343-357
    • Penkowa, M.1    Moos, T.2    Carrasco, J.3    Hadberg, H.4    Molinero, A.5    Bluethmann, H.6
  • 53
    • 0024466595 scopus 로고
    • Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats
    • Hama T, Miyamoto M, Tsukui H, Nishio C, Hatanaka H. Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci Lett. 1989;104(3):340-4.
    • (1989) Neurosci Lett , vol.104 , Issue.3 , pp. 340-344
    • Hama, T.1    Miyamoto, M.2    Tsukui, H.3    Nishio, C.4    Hatanaka, H.5
  • 54
    • 21044442392 scopus 로고    scopus 로고
    • Prostaglandins and cyclooxygenases in glial cells during brain inflammation
    • Tzeng SF, Hsiao HY, Mak OT. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy. 2005;4(3):335-40.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , Issue.3 , pp. 335-340
    • Tzeng, S.F.1    Hsiao, H.Y.2    Mak, O.T.3
  • 56
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol. 2004;63(9):901-10.
    • (2004) J Neuropathol Exp Neurol , vol.63 , Issue.9 , pp. 901-910
    • Minghetti, L.1
  • 57
    • 0030044480 scopus 로고    scopus 로고
    • Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer
    • Liabakk N-B, Talbot I, Smith RA, Wilkinson K, Balkwill F. Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res. 1996;56(1):190-6.
    • (1996) Cancer Res , vol.56 , Issue.1 , pp. 190-196
    • Liabakk, N.-B.1    Talbot, I.2    Smith, R.A.3    Wilkinson, K.4    Balkwill, F.5
  • 58
    • 84863230646 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage
    • Liu J, Jin X, Liu KJ, Liu W. Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci. 2012;32(9):3044-57.
    • (2012) J Neurosci , vol.32 , Issue.9 , pp. 3044-3057
    • Liu, J.1    Jin, X.2    Liu, K.J.3    Liu, W.4
  • 59
    • 84924623154 scopus 로고    scopus 로고
    • Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration
    • Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, et al. Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration. Cell Rep. 2015;10(7):1040-54.
    • (2015) Cell Rep , vol.10 , Issue.7 , pp. 1040-1054
    • Song, J.1    Wu, C.2    Korpos, E.3    Zhang, X.4    Agrawal, S.M.5    Wang, Y.6
  • 60
    • 84880917848 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis
    • Dal-Pizzol F, Rojas HA, dos Santos EM, Vuolo F, Constantino L, Feier G, et al. Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis. Mol Neurobiol. 2013;48(1):62-70.
    • (2013) Mol Neurobiol , vol.48 , Issue.1 , pp. 62-70
    • Dal-Pizzol, F.1    Rojas, H.A.2    Santos, E.M.3    Vuolo, F.4    Constantino, L.5    Feier, G.6
  • 61
    • 0034765067 scopus 로고    scopus 로고
    • Glioma cell invasion: regulation of metalloproteinase activity by TGF-β
    • Wick W, Platten M, Weller M. Glioma cell invasion: regulation of metalloproteinase activity by TGF-β. J Neurooncol. 2001;53(2):177-85.
    • (2001) J Neurooncol , vol.53 , Issue.2 , pp. 177-185
    • Wick, W.1    Platten, M.2    Weller, M.3
  • 62
    • 0033038483 scopus 로고    scopus 로고
    • Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas
    • Forsyth P, Wong H, Laing T, Rewcastle N, Morris D, Muzik H, et al. Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. Br J Cancer. 1999;79(11-12):1828.
    • (1999) Br J Cancer , vol.79 , Issue.11-12 , pp. 1828
    • Forsyth, P.1    Wong, H.2    Laing, T.3    Rewcastle, N.4    Morris, D.5    Muzik, H.6
  • 63
    • 84872684798 scopus 로고    scopus 로고
    • TGF-β as a therapeutic target in high grade gliomas-promises and challenges
    • Joseph JV, Balasubramaniyan V, Walenkamp A, Kruyt FA. TGF-β as a therapeutic target in high grade gliomas-promises and challenges. Biochem Pharmacol. 2013;85(4):478-85.
    • (2013) Biochem Pharmacol , vol.85 , Issue.4 , pp. 478-485
    • Joseph, J.V.1    Balasubramaniyan, V.2    Walenkamp, A.3    Kruyt, F.A.4
  • 64
    • 33745947969 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall
    • Wang M, Zhao D, Spinetti G, Zhang J, Jiang LQ, Pintus G, et al. Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol. 2006;26(7):1503-9.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , Issue.7 , pp. 1503-1509
    • Wang, M.1    Zhao, D.2    Spinetti, G.3    Zhang, J.4    Jiang, L.Q.5    Pintus, G.6
  • 65
    • 84916226547 scopus 로고    scopus 로고
    • p38 MAP kinase mediates transforming-growth factor-beta1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes
    • Takahashi Y, Maki T, Liang AC, Itoh K, Lok J, Osumi N, et al. p38 MAP kinase mediates transforming-growth factor-beta1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes. Brain Res. 2014;1593:1-8.
    • (2014) Brain Res , vol.1593 , pp. 1-8
    • Takahashi, Y.1    Maki, T.2    Liang, A.C.3    Itoh, K.4    Lok, J.5    Osumi, N.6
  • 66
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
    • Bedard K, Krause K-H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1):245-313.
    • (2007) Physiol Rev , vol.87 , Issue.1 , pp. 245-313
    • Bedard, K.1    Krause, K.-H.2
  • 67
    • 0037177164 scopus 로고    scopus 로고
    • Superoxide production and expression of nox family proteins in human atherosclerosis
    • Sorescu D, Weiss D, Lassègue B, Clempus RE, Szöcs K, Sorescu GP, et al. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation. 2002;105(12):1429-35.
    • (2002) Circulation , vol.105 , Issue.12 , pp. 1429-1435
    • Sorescu, D.1    Weiss, D.2    Lassègue, B.3    Clempus, R.E.4    Szöcs, K.5    Sorescu, G.P.6
  • 68
    • 35649015344 scopus 로고    scopus 로고
    • NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    • Kahles T, Luedike P, Endres M, Galla H-J, Steinmetz H, Busse R, et al. NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke. 2007;38(11):3000-6.
    • (2007) Stroke , vol.38 , Issue.11 , pp. 3000-3006
    • Kahles, T.1    Luedike, P.2    Endres, M.3    Galla, H.-J.4    Steinmetz, H.5    Busse, R.6
  • 69
    • 65249103435 scopus 로고    scopus 로고
    • Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-aα in cerebral vascular endothelial cells
    • Basuroy S, Bhattacharya S, Leffler CW, Parfenova H. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-aα in cerebral vascular endothelial cells. Am J Physiol Cell Physiol. 2009;296(3):C422-32.
    • (2009) Am J Physiol Cell Physiol , vol.296 , Issue.3 , pp. C422-C432
    • Basuroy, S.1    Bhattacharya, S.2    Leffler, C.W.3    Parfenova, H.4
  • 70
    • 9144255403 scopus 로고    scopus 로고
    • Nox4 as the major catalytic component of an endothelial NAD (P) H oxidase
    • Ago T, Kitazono T, Ooboshi H, Iyama T, Han YH, Takada J, et al. Nox4 as the major catalytic component of an endothelial NAD (P) H oxidase. Circulation. 2004;109(2):227-33.
    • (2004) Circulation , vol.109 , Issue.2 , pp. 227-233
    • Ago, T.1    Kitazono, T.2    Ooboshi, H.3    Iyama, T.4    Han, Y.H.5    Takada, J.6
  • 71
    • 36048979879 scopus 로고    scopus 로고
    • Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro
    • Datla SR, Peshavariya H, Dusting GJ, Mahadev K, Goldstein BJ, Jiang F. Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro. Arterioscler Thromb Vasc Biol. 2007;27(11):2319-24.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.11 , pp. 2319-2324
    • Datla, S.R.1    Peshavariya, H.2    Dusting, G.J.3    Mahadev, K.4    Goldstein, B.J.5    Jiang, F.6
  • 74
    • 84924250456 scopus 로고    scopus 로고
    • Nox4 is a major source of superoxide production in human brain pericytes
    • Kuroda J, Ago T, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, et al. Nox4 is a major source of superoxide production in human brain pericytes. J Vasc Res. 2014;51(6):429-38.
    • (2014) J Vasc Res , vol.51 , Issue.6 , pp. 429-438
    • Kuroda, J.1    Ago, T.2    Nishimura, A.3    Nakamura, K.4    Matsuo, R.5    Wakisaka, Y.6
  • 75
    • 0025161990 scopus 로고
    • VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
    • Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 1990;60(4):577-84.
    • (1990) Cell , vol.60 , Issue.4 , pp. 577-584
    • Elices, M.J.1    Osborn, L.2    Takada, Y.3    Crouse, C.4    Luhowskyj, S.5    Hemler, M.E.6
  • 76
    • 0028791506 scopus 로고
    • Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1
    • Greenwood J, Wang Y, Calder V. Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. Immunology. 1995;86(3):408.
    • (1995) Immunology , vol.86 , Issue.3 , pp. 408
    • Greenwood, J.1    Wang, Y.2    Calder, V.3
  • 77
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: the leukocyte adhesion cascade updated
    • Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7(9):678-89.
    • (2007) Nat Rev Immunol , vol.7 , Issue.9 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 78
    • 34249815827 scopus 로고    scopus 로고
    • Regulation of cell adhesion by affinity and conformational unbending of aα4β1 integrin
    • Chigaev A, Waller A, Zwartz GJ, Buranda T, Sklar LA. Regulation of cell adhesion by affinity and conformational unbending of aα4β1 integrin. J Immunol. 2007;178(11):6828-39.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 6828-6839
    • Chigaev, A.1    Waller, A.2    Zwartz, G.J.3    Buranda, T.4    Sklar, L.A.5
  • 79
    • 84871189221 scopus 로고    scopus 로고
    • Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
    • Stark K, Eckart A, Haidari S, Tirniceriu A, Lorenz M, von Bruhl ML, et al. Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs. Nat Immunol. 2013;14(1):41-51.
    • (2013) Nat Immunol , vol.14 , Issue.1 , pp. 41-51
    • Stark, K.1    Eckart, A.2    Haidari, S.3    Tirniceriu, A.4    Lorenz, M.5    Bruhl, M.L.6
  • 81
    • 84867819155 scopus 로고    scopus 로고
    • Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation
    • Sagar D, Lamontagne A, Foss CA, Khan ZK, Pomper MG, Jain P. Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation. J Neuroinflammation. 2012;9:245.
    • (2012) J Neuroinflammation , vol.9 , pp. 245
    • Sagar, D.1    Lamontagne, A.2    Foss, C.A.3    Khan, Z.K.4    Pomper, M.G.5    Jain, P.6
  • 83
    • 0030723388 scopus 로고    scopus 로고
    • Identification and molecular characterization of fractalkine receptor CX 3 CR1, which mediates both leukocyte migration and adhesion
    • Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, et al. Identification and molecular characterization of fractalkine receptor CX 3 CR1, which mediates both leukocyte migration and adhesion. Cell. 1997;91(4):521-30.
    • (1997) Cell , vol.91 , Issue.4 , pp. 521-530
    • Imai, T.1    Hieshima, K.2    Haskell, C.3    Baba, M.4    Nagira, M.5    Nishimura, M.6
  • 84
    • 0034743823 scopus 로고    scopus 로고
    • Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1
    • Umehara H, Goda S, Imai T, Nagano Y, Minami Y, Tanaka Y, et al. Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1. Immunol Cell Biol. 2001;79(3):298-302.
    • (2001) Immunol Cell Biol , vol.79 , Issue.3 , pp. 298-302
    • Umehara, H.1    Goda, S.2    Imai, T.3    Nagano, Y.4    Minami, Y.5    Tanaka, Y.6
  • 85
    • 0030949298 scopus 로고    scopus 로고
    • Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    • Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo J-A, et al. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature. 1997;387(6633):611-6.
    • (1997) Nature , vol.387 , Issue.6633 , pp. 611-616
    • Pan, Y.1    Lloyd, C.2    Zhou, H.3    Dolich, S.4    Deeds, J.5    Gonzalo, J.-A.6
  • 87
    • 0032547581 scopus 로고    scopus 로고
    • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow
    • Fong AM, Robinson LA, Steeber DA, Tedder TF, Yoshie O, Imai T, et al. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. J Exp Med. 1998;188(8):1413-9.
    • (1998) J Exp Med , vol.188 , Issue.8 , pp. 1413-1419
    • Fong, A.M.1    Robinson, L.A.2    Steeber, D.A.3    Tedder, T.F.4    Yoshie, O.5    Imai, T.6
  • 89
    • 84897478440 scopus 로고    scopus 로고
    • Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage
    • Sheridan GK, Murphy KJ. Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biol. 2013;3(12):130181.
    • (2013) Open Biol , vol.3 , Issue.12 , pp. 130181
    • Sheridan, G.K.1    Murphy, K.J.2
  • 90
    • 0032510831 scopus 로고    scopus 로고
    • Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?
    • Nishiyori A, Minami M, Ohtani Y, Takami S, Yamamoto J, Kawaguchi N, et al. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett. 1998;429(2):167-72.
    • (1998) FEBS Lett , vol.429 , Issue.2 , pp. 167-172
    • Nishiyori, A.1    Minami, M.2    Ohtani, Y.3    Takami, S.4    Yamamoto, J.5    Kawaguchi, N.6
  • 91
    • 44949173099 scopus 로고    scopus 로고
    • Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
    • Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, et al. Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med. 2008;14(6):681-7.
    • (2008) Nat Med , vol.14 , Issue.6 , pp. 681-687
    • Town, T.1    Laouar, Y.2    Pittenger, C.3    Mori, T.4    Szekely, C.A.5    Tan, J.6
  • 92
    • 0142139197 scopus 로고    scopus 로고
    • FGF-2 antagonizes the TGF-beta1-mediated induction of pericyte alpha-smooth muscle actin expression: a role for myf-5 and Smad-mediated signaling pathways.
    • Papetti M, Shujath J, Riley KN, Herman IM. FGF-2 antagonizes the TGF-beta1-mediated induction of pericyte alpha-smooth muscle actin expression: a role for myf-5 and Smad-mediated signaling pathways. Invest Ophthalmol Vis Sci. 2003;44(11):4994-5005.
    • (2003) Invest Ophthalmol Vis Sci. , vol.44 , Issue.11 , pp. 4994-5005
    • Papetti, M.1    Shujath, J.2    Riley, K.N.3    Herman, I.M.4
  • 93
    • 78649716241 scopus 로고    scopus 로고
    • Transforming growth factor-b1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK-and JNK-NF-kB pathways
    • Hsieh H-L, Wang H-H, Wu W-B, Chu P-J, Yang C-M. Transforming growth factor-b1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK-and JNK-NF-kB pathways. J Neuroinflammation. 2010;7:88.
    • (2010) J Neuroinflammation , vol.7 , pp. 88
    • Hsieh, H.-L.1    Wang, H.-H.2    Wu, W.-B.3    Chu, P.-J.4    Yang, C.-M.5
  • 94
    • 0030570452 scopus 로고    scopus 로고
    • NF-κB is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors
    • Obata H, Biro S, Arima N, Kaieda H, Kihara T, Eto H, et al. NF-κB is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors. Biochem Biophys Res Commun. 1996;224(1):27-32.
    • (1996) Biochem Biophys Res Commun , vol.224 , Issue.1 , pp. 27-32
    • Obata, H.1    Biro, S.2    Arima, N.3    Kaieda, H.4    Kihara, T.5    Eto, H.6
  • 96
    • 0033407485 scopus 로고    scopus 로고
    • Brain macrophages: on the role of pericytes and perivascular cells
    • Thomas WE. Brain macrophages: on the role of pericytes and perivascular cells. Brain Res Rev. 1999;31(1):42-57.
    • (1999) Brain Res Rev , vol.31 , Issue.1 , pp. 42-57
    • Thomas, W.E.1
  • 97
    • 0030764732 scopus 로고    scopus 로고
    • Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease
    • Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, et al. Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease. Nature. 1997;389(6651):603-6.
    • (1997) Nature , vol.389 , Issue.6651 , pp. 603-606
    • Wyss-Coray, T.1    Masliah, E.2    Mallory, M.3    McConlogue, L.4    Johnson-Wood, K.5    Lin, C.6
  • 100
    • 0036847848 scopus 로고    scopus 로고
    • Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system
    • Husemann J, Loike JD, Anankov R, Febbraio M, Silverstein SC. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia. 2002;40(2):195-205.
    • (2002) Glia , vol.40 , Issue.2 , pp. 195-205
    • Husemann, J.1    Loike, J.D.2    Anankov, R.3    Febbraio, M.4    Silverstein, S.C.5
  • 101
    • 0034122925 scopus 로고    scopus 로고
    • The role of scavenger receptors in the innate immune system
    • Gough PJ, Gordon S. The role of scavenger receptors in the innate immune system. Microbes Infect. 2000;2(3):305-11.
    • (2000) Microbes Infect , vol.2 , Issue.3 , pp. 305-311
    • Gough, P.J.1    Gordon, S.2
  • 102
    • 7744235869 scopus 로고    scopus 로고
    • Microglial phagocytosis of fibrillar β-amyloid through a β1 integrin-dependent mechanism
    • Koenigsknecht J, Landreth G. Microglial phagocytosis of fibrillar β-amyloid through a β1 integrin-dependent mechanism. J Neurosci. 2004;24(44):9838-46.
    • (2004) J Neurosci , vol.24 , Issue.44 , pp. 9838-9846
    • Koenigsknecht, J.1    Landreth, G.2
  • 103
    • 0037387147 scopus 로고    scopus 로고
    • A cell surface receptor complex for fibrillar β-amyloid mediates microglial activation
    • Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE. A cell surface receptor complex for fibrillar β-amyloid mediates microglial activation. J Neurosci. 2003;23(7):2665-74.
    • (2003) J Neurosci , vol.23 , Issue.7 , pp. 2665-2674
    • Bamberger, M.E.1    Harris, M.E.2    McDonald, D.R.3    Husemann, J.4    Landreth, G.E.5
  • 104
    • 0034014222 scopus 로고    scopus 로고
    • TGF-β1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages
    • Draude G, Lorenz RL. TGF-β1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages. Am J Physiol Heart Circ Physiol. 2000;278(4):H1042-8.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278 , Issue.4 , pp. H1042-H1048
    • Draude, G.1    Lorenz, R.L.2
  • 105
    • 0033968252 scopus 로고    scopus 로고
    • Transforming growth factor-β1 (TGF-β1) and TGF-β2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-γ
    • Han J, Hajjar DP, Tauras JM, Feng J, Gotto AM, Nicholson AC. Transforming growth factor-β1 (TGF-β1) and TGF-β2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-γ. J Biol Chem. 2000;275(2):1241-6.
    • (2000) J Biol Chem , vol.275 , Issue.2 , pp. 1241-1246
    • Han, J.1    Hajjar, D.P.2    Tauras, J.M.3    Feng, J.4    Gotto, A.M.5    Nicholson, A.C.6
  • 106
    • 84903159199 scopus 로고    scopus 로고
    • Nox4 and redox signaling mediate TGF-beta-induced endothelial cell apoptosis and phenotypic switch
    • Yan F, Wang Y, Wu X, Peshavariya HM, Dusting GJ, Zhang M, et al. Nox4 and redox signaling mediate TGF-beta-induced endothelial cell apoptosis and phenotypic switch. Cell Death Dis. 2014;5, e1010.
    • (2014) Cell Death Dis , vol.5
    • Yan, F.1    Wang, Y.2    Wu, X.3    Peshavariya, H.M.4    Dusting, G.J.5    Zhang, M.6
  • 107
    • 84938096217 scopus 로고    scopus 로고
    • TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5.
    • McMillin MA, Frampton GA, Seiwell AP, Patel NS, Jacobs AN, DeMorrow S. TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5. Lab Investig. 2015.
    • (2015) Lab Investig.
    • McMillin, M.A.1    Frampton, G.A.2    Seiwell, A.P.3    Patel, N.S.4    Jacobs, A.N.5    DeMorrow, S.6
  • 108
    • 84924110689 scopus 로고    scopus 로고
    • TGF-β1 prevents blood-brain barrier damage and hemorrhagic transformation after thrombolysis in rats
    • Cai Y, Liu X, Chen W, Wang Z, Xu G, Zeng Y, et al. TGF-β1 prevents blood-brain barrier damage and hemorrhagic transformation after thrombolysis in rats. Exp Neurol. 2015;266:120-6.
    • (2015) Exp Neurol , vol.266 , pp. 120-126
    • Cai, Y.1    Liu, X.2    Chen, W.3    Wang, Z.4    Xu, G.5    Zeng, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.