Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Sagar, Divya ^a   Lamontagne, Anne ^a   Foss, Catherine A ^b   Khan, Zafar K ^a   Pomper, Martin G ^b   Jain, Pooja ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Blood brain barrier; Brain microvascular endothelial cells; Chemokine ligand 2; Dendritic cell central nervous system trafficking; MCP 1; Near infrared fluorescence imaging; Neuroinflammation

Indexed keywords

GLYCOPROTEIN P 15095; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; PERTUSSIS TOXIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LABELING; CELL METABOLISM; CELL MIGRATION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVATION; EX VIVO STUDY; FEMALE; FLUORESCENCE MICROSCOPY; HISTOLOGY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; INTRACELLULAR SIGNALING; MICROVASCULAR ENDOTHELIAL CELL; MOLECULAR MECHANICS; MONOCYTE; MOUSE; NEAR INFRARED SPECTROSCOPY; NEUROPHYSIOLOGICAL RECRUITMENT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCORING SYSTEM;

EID: 84867819155     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-245     Document Type: Article

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