TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

Laboratory Investigation

Volumn 95, Issue 8, 2015, Pages 903-913

  McMillin, Matthew A ^a   Frampton, Gabriel A ^a   Seiwell, Andrew P ^a   Patel, Nisha S ^a   Jacobs, Amber N ^b   DeMorrow, Sharon ^a,c,d  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; CLAUDIN 5; EVANS BLUE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GELATINASE B; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; SMAD3 PROTEIN; TIGHT JUNCTION PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN INHIBITOR; CLDN5 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL PERMEABILIZATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; HEPATIC ENCEPHALOPATHY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PATHOGENESIS; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELL LINE; CLAUDIN-5; DOWN-REGULATION; HEPATIC ENCEPHALOPATHY; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84938096217     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.70     Document Type: Article

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