Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

Neuroscience Letters

Volumn 578, Issue , 2014, Pages 133-138

  Matsumoto, Junichi ^a   Takata, Fuyuko ^a,b   Machida, Takashi ^a   Takahashi, Hiroyuki ^a   Soejima, Yuki ^a   Funakoshi, Miho ^a   Futagami, Koujiro ^a   Yamauchi, Atsushi ^a   Dohgu, Shinya ^a   Kataoka, Yasufumi ^a,b  

^a FUKUOKA UNIVERSITY   (Japan)

^b PharmaCo Cell Company   (Japan)

Author keywords

Blood brain barrier; Brain inflammation; Microglia; Neurovascular unit; Pericytes; Tumor necrosis factor

Indexed keywords

CHEMOKINE; CYTOKINE; EOTAXIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN PERICYTE; CELL ACTIVATION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENCEPHALITIS; MICROGLIA; MICROVASCULAR ENDOTHELIAL CELL; MONOCULTURE; MOUSE; NONHUMAN; PERICYTE; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; ANIMAL; BLOOD BRAIN BARRIER; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; PRIMARY CELL CULTURE; WISTAR RAT;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; CHEMOKINES; CYTOKINES; ENCEPHALITIS; ENDOTHELIAL CELLS; INTERLEUKIN-1BETA; MICROGLIA; NITRIC OXIDE SYNTHASE; PERICYTES; PRIMARY CELL CULTURE; RATS; RATS, WISTAR; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904370000     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.06.052     Document Type: Article

References (28)

1. Zlokovic B.V. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 2011, 12:723-738.
2. Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140:918-934.
3. Yang Y., Jalal F.Y., Thompson J.F., Walker E.J., Candelario-Jalil E., Li L., Reichard R.R., Ben C., Sang Q.X., Cunningham L.A., Rosenberg G.A. Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice. J. Neuroinflamm. 2011, 8:108.
4. Yaturu S., Rains J., Jain S.K. Relationship of elevated osteoprotegerin with insulin resistance, CRP, and TNF-alpha levels in men with type 2 diabetes. Cytokine 2008, 44:168-171.
5. Aygun A.D., Gungor S., Ustundag B., Gurgoze M.K., Sen Y. Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children. Mediat. Inflamm. 2005, 2005:180-183.
6. Wang T., Fu F., Han B., Zhang L., Zhang X. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J. Neuroimmunol. 2012, 245:79-86.
7. Pistell P.J., Morrison C.D., Gupta S., Knight A.G., Keller J.N., Ingram D.K., Bruce-Keller A.J. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J. Neuroimmunol. 2010, 219:25-32.
8. Balabanov R., Washington R., Wagnerova J., Dore-Duffy P. CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2. Microvasc. Res. 1996, 52:127-142.
9. Kovac A., Erickson M.A., Banks W.A. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J. Neuroinflamm. 2011, 8:139.
10. Takata F., Dohgu S., Matsumoto J., Takahashi H., Machida T., Wakigawa T., Harada E., Miyaji H., Koga M., Nishioku T., Yamauchi A., Kataoka Y. Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro. J. Neuroinflamm. 2011, 8:106.
11. Vilhardt F. Microglia: phagocyte and glia cell. Int. J. Biochem. Cell Biol. 2005, 37:17-21.
12. Matsumoto J., Dohgu S., Takata F., Nishioku T., Sumi N., Machida T., Takahashi H., Yamauchi A., Kataoka Y. Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells. Neurosci. Lett. 2012, 524:45-48.
13. Sacha B., Zierler S., Lehnardt S., Weber J.R., Kerschbaum H.H. Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells. J. Neurosci. Res. 2008, 86:3526-3535.
14. Shi F., Yang L., Kouadir M., Yang Y., Wang J., Zhou X., Yin X., Zhao D. The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. J. Neuroinflamm. 2012, 9:73.
15. Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
16. Leung L., Cahill C.M. TNF-alpha and neuropathic pain - a review. J. Neuroinflamm. 2010, 7:27.
17. Pieper C., Marek J.J., Unterberg M., Schwerdtle T., Galla H.J. Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro. Brain Res. 2014, 1550:1-8.
18. Louboutin J.P., Chekmasova A., Marusich E., Agrawal L., Strayer D.S. Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. FASEB J. 2011, 25:737-753.
19. Pieper C., Pieloch P., Galla H.J. Pericytes support neutrophil transmigration via interleukin-8 across a porcine co-culture model of the blood-brain barrier. Brain Res. 2013, 1524:1-11.
20. Lei B., Dawson H.N., Roulhac-Wilson B., Wang H., Laskowitz D.T., James M.L. Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage. J. Neuroinflamm. 2013, 10:103.
21. Mantuano E., Inoue G., Li X., Takahashi K., Gaultier A., Gonias S.L., Campana W.M. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of Schwann cells by binding to low-density lipoprotein receptor-related protein. J. Neurosci. 2008, 28:11571-11582.
22. Zhang C., An J., Strickland D.K., Yepes M. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am. J. Pathol. 2009, 174:586-594.
23. Cardenas H., Bolin L.M. Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice. Brain Res. 2003, 985:89-97.
24. Candelario-Jalil E., Taheri S., Yang Y., Sood R., Grossetete M., Estrada E.Y., Fiebich B.L., Rosenberg G.A. Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J. Pharmacol. Exp. Ther. 2007, 323:488-498.
25. Stalder A.K., Carson M.J., Pagenstecher A., Asensio V.C., Kincaid C., Benedict M., Powell H.C., Masliah E., Campbell I.L. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am. J. Pathol. 1998, 153:767-783.
26. Kong G.Y., Peng Z.C., Costanzo C., Kristensson K., Bentivoglio M. Inducible nitric oxide synthase expression elicited in the mouse brain by inflammatory mediators circulating in the cerebrospinal fluid. Brain Res. 2000, 878:105-118.
27. Ehrlich L.C., Hu S., Sheng W.S., Sutton R.L., Rockswold G.L., Peterson P.K., Chao C.C. Cytokine regulation of human microglial cell IL-8 production. J. Immunol. 1998, 160:1944-1948.
28. Sawada M., Suzumura A., Marunouchi T. TNF alpha induces IL-6 production by astrocytes but not by microglia. Brain Res. 1992, 583:296-299.