Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells

Environmental Toxicology

Volumn 31, Issue 3, 2016, Pages 314-328

  King, Yih An ^a   Chiu, Yu Jen ^b   Chen, Hao Ping ^c   Kuo, Daih Huang ^d   Lu, Chi Cheng ^e   Yang, Jai Sing ^f  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d TAJEN UNIVERSITY   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^f Bracco Pharmaceutical Corp Ltd   (Taiwan)

Author keywords

Apoptosis; Arsenic trioxide; ER stress; Mesenchymal stem cells; Mitochondria

Indexed keywords

BONE; CALCIUM; CELL CULTURE; CELL DEATH; CELL MEMBRANES; CELLS; CYTOLOGY; CYTOTOXICITY; GENE EXPRESSION; MITOCHONDRIA; STEM CELLS;

ARSENIC TRIOXIDE; BONE MARROW MESENCHYMAL STEM CELLS; ENDOPLASMIC RETICULUM STRESS; ER STRESS; FLOW-CYTOMETRIC ANALYSIS; HUMAN BONE MARROW DERIVED MESENCHYMAL STEM CELLS; MESENCHYMAL STEM CELL; MITOCHONDRIAL MEMBRANE POTENTIAL;

ARSENIC;

ACTIVATING TRANSCRIPTION FACTOR 6; ACTIVATING TRANSCRIPTION FACTOR 6 ALPHA; ACTIVATING TRANSCRIPTION FACTOR 6 BETA; ARSENIC TRIOXIDE; CALCIUM ION; CALPAIN 1; CASPASE 3; CASPASE 4; CASPASE 9; CYCLOPHILIN A; CYCLOSPORIN A; ELONGATION FACTOR 1ALPHA; EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 ALPHA 1; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 27; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H1; HIGH MOBILITY GROUP B1 PROTEIN; INITIATION FACTOR 2ALPHA; LIPOCORTIN 1; MYOSIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; VIMENTIN; ORGANOARSENIC DERIVATIVE; OXIDE; PROTEOME;

APOPTOSIS; ARSENIC; BIOASSAY; CANCER; CELLS AND CELL COMPONENTS; DRUG; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; MITOCHONDRION; TOXICITY TEST; TRADITIONAL MEDICINE;

APOPTOSIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DOWN REGULATION; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MESENCHYMAL STEM CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; UMBILICAL CORD; UMBILICAL MESENCHYMAL STEM CELL; UPREGULATION; BONE MARROW CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FETUS BLOOD; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CHINA;

APOPTOSIS; ARSENICALS; BONE MARROW CELLS; CASPASE 3; CASPASE 9; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; FETAL BLOOD; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCHYMAL STROMAL CELLS; MITOCHONDRIA; OXIDES; PROTEOME; SIGNAL TRANSDUCTION;

EID: 84957695116     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.22046     Document Type: Article

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