-
1
-
-
0036715589
-
How acute promyelocytic leukemia revived arsenic
-
Zhu J., et al. How acute promyelocytic leukemia revived arsenic. Nat. Rev. Cancer 2002, 2:705-713.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 705-713
-
-
Zhu, J.1
-
2
-
-
79959473062
-
From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia
-
Chen S.J., et al. From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood 2011, 117:6425-6437.
-
(2011)
Blood
, vol.117
, pp. 6425-6437
-
-
Chen, S.J.1
-
3
-
-
77954287020
-
PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3
-
Jeanne M., et al. PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. Cancer Cell 2010, 18:88-98.
-
(2010)
Cancer Cell
, vol.18
, pp. 88-98
-
-
Jeanne, M.1
-
4
-
-
77950826446
-
Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML
-
Zhang X.W., et al. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 2010, 328:240-243.
-
(2010)
Science
, vol.328
, pp. 240-243
-
-
Zhang, X.W.1
-
5
-
-
77950825339
-
Medicine. Poisonous contacts
-
Kogan S.C. Medicine. Poisonous contacts. Science 2010, 328:184-185.
-
(2010)
Science
, vol.328
, pp. 184-185
-
-
Kogan, S.C.1
-
6
-
-
41949111045
-
Acute promyelocytic leukemia: from highly fatal to highly curable
-
Wang Z.Y., Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008, 111:2505-2515.
-
(2008)
Blood
, vol.111
, pp. 2505-2515
-
-
Wang, Z.Y.1
Chen, Z.2
-
7
-
-
11144355810
-
3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia
-
3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:5328-5335.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 5328-5335
-
-
Shen, Z.X.1
-
8
-
-
73949097021
-
How I treat acute promyelocytic leukemia
-
Tallman M.S., Altman J.K. How I treat acute promyelocytic leukemia. Blood 2009, 114:5126-5135.
-
(2009)
Blood
, vol.114
, pp. 5126-5135
-
-
Tallman, M.S.1
Altman, J.K.2
-
9
-
-
33646386643
-
Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia
-
Estey E., et al. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Blood 2006, 107:3469-3473.
-
(2006)
Blood
, vol.107
, pp. 3469-3473
-
-
Estey, E.1
-
10
-
-
77958510339
-
Acute promyelocytic leukaemia: novel insights into the mechanisms of cure
-
de The H., Chen Z. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. Nat. Rev. Cancer 2010, 10:775-783.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 775-783
-
-
de The, H.1
Chen, Z.2
-
11
-
-
84855598236
-
Oncoprotein proteolysis, an unexpected Achille's heel of cancer cells?
-
Ablain J., et al. Oncoprotein proteolysis, an unexpected Achille's heel of cancer cells?. Cancer Discov. 2011, 1:117-127.
-
(2011)
Cancer Discov.
, vol.1
, pp. 117-127
-
-
Ablain, J.1
-
12
-
-
61849146788
-
Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
-
Akagi T., et al. Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations. Blood 2009, 113:1741-1748.
-
(2009)
Blood
, vol.113
, pp. 1741-1748
-
-
Akagi, T.1
-
13
-
-
79953299687
-
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression
-
Wartman L.D., et al. Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J. Clin. Invest. 2011, 121:1445-1455.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1445-1455
-
-
Wartman, L.D.1
-
14
-
-
78649395022
-
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
-
Jones L., et al. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J. Exp. Med. 2010, 207:2581-2594.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2581-2594
-
-
Jones, L.1
-
15
-
-
13844299891
-
PML/RARA-RXR oligomers mediate retinoid- and rexinoid/cAMP in APL cell differentiation
-
Kamashev D.E., et al. PML/RARA-RXR oligomers mediate retinoid- and rexinoid/cAMP in APL cell differentiation. J. Exp. Med. 2004, 199:1-13.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1-13
-
-
Kamashev, D.E.1
-
16
-
-
76249101323
-
PML-RARalpha/RXR alters the epigenetic landscape in acute promyelocytic leukemia
-
Martens J.H., et al. PML-RARalpha/RXR alters the epigenetic landscape in acute promyelocytic leukemia. Cancer Cell 2010, 17:173-185.
-
(2010)
Cancer Cell
, vol.17
, pp. 173-185
-
-
Martens, J.H.1
-
18
-
-
0035341813
-
P53 and PML: new partners in tumor suppression
-
Gottifredi V., Prives C. P53 and PML: new partners in tumor suppression. Trends Cell Biol. 2001, 11:184-187.
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 184-187
-
-
Gottifredi, V.1
Prives, C.2
-
19
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson M., et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 2000, 406:207-210.
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
-
20
-
-
44349166602
-
PML targeting eradicates quiescent leukaemia-initiating cells
-
Ito K., et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008, 453:1072-1078.
-
(2008)
Nature
, vol.453
, pp. 1072-1078
-
-
Ito, K.1
-
21
-
-
58849151893
-
The tumor suppressor Pml regulates cell fate in the developing neocortex
-
Regad T., et al. The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat. Neurosci. 2009, 12:132-140.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 132-140
-
-
Regad, T.1
-
22
-
-
77954464666
-
P53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
-
Zhao Z., et al. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev. 2010, 24:1389-1402.
-
(2010)
Genes Dev.
, vol.24
, pp. 1389-1402
-
-
Zhao, Z.1
-
23
-
-
70349123829
-
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
-
Cicalese A., et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009, 138:1083-1095.
-
(2009)
Cell
, vol.138
, pp. 1083-1095
-
-
Cicalese, A.1
-
24
-
-
33745161824
-
Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization
-
Zhou J., et al. Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:9238-9243.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 9238-9243
-
-
Zhou, J.1
-
25
-
-
0033592948
-
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RAR alpha) and oncogenic RAR alpha fusion proteins
-
Zhu J., et al. Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RAR alpha) and oncogenic RAR alpha fusion proteins. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:14807-14812.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 14807-14812
-
-
Zhu, J.1
-
26
-
-
79953795052
-
New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor alpha recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation
-
Cassinat B., et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor alpha recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation. Mol. Cell. Biol. 2011, 31:1409-1418.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 1409-1418
-
-
Cassinat, B.1
-
27
-
-
57349152259
-
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
-
Nasr R., et al. Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat. Med. 2008, 14:1333-1342.
-
(2008)
Nat. Med.
, vol.14
, pp. 1333-1342
-
-
Nasr, R.1
-
28
-
-
57849111781
-
Curing APL: differentiation or destruction?
-
Kogan S.C. Curing APL: differentiation or destruction?. Cancer Cell 2009, 15:7-8.
-
(2009)
Cancer Cell
, vol.15
, pp. 7-8
-
-
Kogan, S.C.1
-
29
-
-
79958002038
-
Revisiting the differentiation paradigm in acute promyelocytic leukemia
-
Ablain J., de The H. Revisiting the differentiation paradigm in acute promyelocytic leukemia. Blood 2011, 117:5795-5802.
-
(2011)
Blood
, vol.117
, pp. 5795-5802
-
-
Ablain, J.1
de The, H.2
-
30
-
-
33746320763
-
Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M.D. Anderson Cancer Center Series
-
Tsimberidou A.M., et al. Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M.D. Anderson Cancer Center Series. Leuk. Lymphoma 2006, 47:1062-1068.
-
(2006)
Leuk. Lymphoma
, vol.47
, pp. 1062-1068
-
-
Tsimberidou, A.M.1
-
31
-
-
77956251955
-
Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data
-
Mathews V., et al. Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data. J. Clin. Oncol. 2010, 28:3866-3871.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 3866-3871
-
-
Mathews, V.1
-
32
-
-
79960225126
-
Phase II study of single-agent arsenic trioxide for the front-line therapy of acute promyelocytic leukemia
-
Ghavamzadeh A., et al. Phase II study of single-agent arsenic trioxide for the front-line therapy of acute promyelocytic leukemia. J. Clin. Oncol. 2011, 29:2753-2757.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2753-2757
-
-
Ghavamzadeh, A.1
-
33
-
-
0037099645
-
Mechanisms of action of arsenic trioxide
-
Miller W.H., et al. Mechanisms of action of arsenic trioxide. Cancer Res. 2002, 62:3893-3903.
-
(2002)
Cancer Res.
, vol.62
, pp. 3893-3903
-
-
Miller, W.H.1
-
34
-
-
0033526358
-
Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations
-
Zhu X.H., et al. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J. Natl. Cancer Inst. 1999, 91:772-778.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 772-778
-
-
Zhu, X.H.1
-
35
-
-
0030890942
-
Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia
-
Zhu J., et al. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:3978-3983.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 3978-3983
-
-
Zhu, J.1
-
36
-
-
0030610686
-
3 exerts dose-dependent dual effects on APL cells
-
3 exerts dose-dependent dual effects on APL cells. Blood 1997, 89:3345-3353.
-
(1997)
Blood
, vol.89
, pp. 3345-3353
-
-
Chen, G.Q.1
-
37
-
-
25844504150
-
Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia
-
Lallemand-Breitenbach V., et al. Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia. Nat. Rev. Cancer 2005, 5:821-827.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 821-827
-
-
Lallemand-Breitenbach, V.1
-
38
-
-
0034730198
-
3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
-
3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:10173-10178.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 10173-10178
-
-
Rego, E.M.1
-
39
-
-
61949441174
-
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
-
Sanz M.A., et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2009, 113:1875-1891.
-
(2009)
Blood
, vol.113
, pp. 1875-1891
-
-
Sanz, M.A.1
-
40
-
-
21144441198
-
Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia
-
Zheng P.Z., et al. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:7653-7658.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 7653-7658
-
-
Zheng, P.Z.1
-
41
-
-
0033916673
-
Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide
-
Camacho L.H., et al. Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide. J. Clin. Oncol. 2000, 18:2620-2625.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 2620-2625
-
-
Camacho, L.H.1
-
42
-
-
0037131973
-
In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia
-
Guillemin M.C., et al. In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia. J. Exp. Med. 2002, 196:1373-1380.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1373-1380
-
-
Guillemin, M.C.1
-
43
-
-
34347270506
-
RXR is an essential component of the oncogenic PML/RARA complex in vivo
-
Zhu J., et al. RXR is an essential component of the oncogenic PML/RARA complex in vivo. Cancer Cell 2007, 12:23-35.
-
(2007)
Cancer Cell
, vol.12
, pp. 23-35
-
-
Zhu, J.1
-
44
-
-
77957716030
-
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
-
Isakson P., et al. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood 2010, 116:2324-2331.
-
(2010)
Blood
, vol.116
, pp. 2324-2331
-
-
Isakson, P.1
-
45
-
-
0000531696
-
Arsenic trioxide as an inducer of apoptosis and loss of PML/RARalpha protein in acute promyelocytic leukemia cells
-
Shao W., et al. Arsenic trioxide as an inducer of apoptosis and loss of PML/RARalpha protein in acute promyelocytic leukemia cells. J. Natl. Cancer Inst. 1998, 90:124-133.
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 124-133
-
-
Shao, W.1
-
46
-
-
0035161286
-
Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo
-
Jing Y., et al. Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. Blood 2001, 97:264-269.
-
(2001)
Blood
, vol.97
, pp. 264-269
-
-
Jing, Y.1
-
47
-
-
62549083523
-
Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
-
Hu J., et al. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:3342-3347.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 3342-3347
-
-
Hu, J.1
-
48
-
-
68049103216
-
An additional role for SUMO in ubiquitin-mediated proteolysis
-
Geoffroy M.C., Hay R.T. An additional role for SUMO in ubiquitin-mediated proteolysis. Nat. Rev. Mol. Cell Biol. 2009, 10:564-568.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 564-568
-
-
Geoffroy, M.C.1
Hay, R.T.2
-
49
-
-
0035908032
-
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As(2)O(3)-induced PML or PML/retinoic acid receptor alpha degradation
-
Lallemand-Breitenbach V., et al. Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As(2)O(3)-induced PML or PML/retinoic acid receptor alpha degradation. J. Exp. Med. 2001, 193:1361-1372.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 1361-1372
-
-
Lallemand-Breitenbach, V.1
-
50
-
-
43049096803
-
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway
-
Lallemand-Breitenbach V., et al. Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat. Cell Biol. 2008, 10:547-555.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 547-555
-
-
Lallemand-Breitenbach, V.1
-
51
-
-
43049093756
-
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
-
Tatham M.H., et al. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell Biol. 2008, 10:538-546.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 538-546
-
-
Tatham, M.H.1
-
52
-
-
34250812094
-
Classification of heavy-metal toxicity by human DNA microarray analysis
-
Kawata K., et al. Classification of heavy-metal toxicity by human DNA microarray analysis. Environ. Sci. Technol. 2007, 41:3769-3774.
-
(2007)
Environ. Sci. Technol.
, vol.41
, pp. 3769-3774
-
-
Kawata, K.1
-
53
-
-
80051635934
-
Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment
-
Goto E., et al. Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment. Blood 2011, 118:1600-1609.
-
(2011)
Blood
, vol.118
, pp. 1600-1609
-
-
Goto, E.1
-
54
-
-
67349155010
-
Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells
-
Freitas R.A., et al. Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells. Leuk. Res. 2009, 33:958-963.
-
(2009)
Leuk. Res.
, vol.33
, pp. 958-963
-
-
Freitas, R.A.1
-
55
-
-
84858001991
-
(+)alpha-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo
-
Dos Santos G.A., et al. (+)alpha-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. Leukemia 2011, 10.1038/leu.2011.216.
-
(2011)
Leukemia
-
-
Dos Santos, G.A.1
-
56
-
-
0035910747
-
Role of promyelocytic leukemia (PML) protein in tumor suppression
-
Rego E.M., et al. Role of promyelocytic leukemia (PML) protein in tumor suppression. J. Exp. Med. 2001, 193:521-530.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 521-530
-
-
Rego, E.M.1
-
57
-
-
12144286886
-
Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia
-
Gurrieri C., et al. Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia. Blood 2004, 103:2358-2362.
-
(2004)
Blood
, vol.103
, pp. 2358-2362
-
-
Gurrieri, C.1
-
58
-
-
10344225622
-
Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein
-
Yin T., et al. Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood 2004, 104:4219-4225.
-
(2004)
Blood
, vol.104
, pp. 4219-4225
-
-
Yin, T.1
-
59
-
-
78650740077
-
As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia
-
Mao J.H., et al. As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:21683-21688.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 21683-21688
-
-
Mao, J.H.1
-
60
-
-
80051899384
-
How I treat adult T-cell leukemia/lymphoma
-
Bazarbachi A., et al. How I treat adult T-cell leukemia/lymphoma. Blood 2011, 118:1736-1745.
-
(2011)
Blood
, vol.118
, pp. 1736-1745
-
-
Bazarbachi, A.1
-
61
-
-
0034667621
-
Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappaB activation
-
El-Sabban M.E., et al. Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappaB activation. Blood 2000, 96:2849-2855.
-
(2000)
Blood
, vol.96
, pp. 2849-2855
-
-
El-Sabban, M.E.1
-
62
-
-
78650373635
-
Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia
-
El Hajj H., et al. Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia. J. Exp. Med. 2010, 207:2785-2792.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2785-2792
-
-
El Hajj, H.1
-
63
-
-
69249235900
-
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)
-
Kchour G., et al. Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL). Blood 2009, 113:6528-6532.
-
(2009)
Blood
, vol.113
, pp. 6528-6532
-
-
Kchour, G.1
-
64
-
-
36448975490
-
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
-
Bernardi R., Pandolfi P.P. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell Biol. 2007, 8:1006-1016.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 1006-1016
-
-
Bernardi, R.1
Pandolfi, P.P.2
-
65
-
-
79952159126
-
Arsenic pollution of groundwater in Vietnam exacerbated by deep aquifer exploitation for more than a century
-
Winkel L.H., et al. Arsenic pollution of groundwater in Vietnam exacerbated by deep aquifer exploitation for more than a century. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:1246-1251.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 1246-1251
-
-
Winkel, L.H.1
-
66
-
-
0035884639
-
United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
-
Soignet S.L., et al. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J. Clin. Oncol. 2001, 19:3852-3860.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 3852-3860
-
-
Soignet, S.L.1
-
67
-
-
0031812159
-
Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription
-
Moilanen A.M., et al. Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 1998, 18:5128-5139.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5128-5139
-
-
Moilanen, A.M.1
-
68
-
-
1342265499
-
Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity
-
Hakli M., et al. Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity. FEBS Lett. 2004, 560:56-62.
-
(2004)
FEBS Lett.
, vol.560
, pp. 56-62
-
-
Hakli, M.1
-
69
-
-
34648816891
-
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins
-
Sun H., et al. Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J. 2007, 26:4102-4112.
-
(2007)
EMBO J.
, vol.26
, pp. 4102-4112
-
-
Sun, H.1
-
70
-
-
34648840192
-
SUMO-targeted ubiquitin ligases in genome stability
-
Prudden J., et al. SUMO-targeted ubiquitin ligases in genome stability. EMBO J. 2007, 26:4089-4101.
-
(2007)
EMBO J.
, vol.26
, pp. 4089-4101
-
-
Prudden, J.1
-
71
-
-
33750447586
-
The mechanisms of PML-nuclear body formation
-
Shen T.H., et al. The mechanisms of PML-nuclear body formation. Mol. Cell 2006, 24:331-339.
-
(2006)
Mol. Cell
, vol.24
, pp. 331-339
-
-
Shen, T.H.1
-
72
-
-
0037498052
-
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
-
Muller S., et al. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. EMBO J. 1998, 17:61-70.
-
(1998)
EMBO J.
, vol.17
, pp. 61-70
-
-
Muller, S.1
|