Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 18969-18979

  Yoda, Akinori ^a   Toyoshima, Kyoko ^a   Watanabe, Yasuhide ^a   Onishi, Nobuyuki ^a   Hazaka, Yuki ^a   Tsukuda, Yusuke ^a   Tsukada, Junichi ^b   Kondo, Takeshi ^d   Tanaka, Yoshiya ^c   Minami, Yasuhiro ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b School of Medicine   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; CELL DEATH; CHEMICAL REACTIONS; DNA; GENES; NUCLEIC ACIDS; ORGANIC ACIDS; POLARIZATION;

APOPTOSIS; APOPTOTIC PATHWAYS; ARSENIC TRIOXIDES; CANCER CHEMOTHERAPEUTIC AGENTS; CELL CYCLES; CULTURED CELLS; DNA DAMAGES; ECTOPIC EXPRESSIONS; IN VITRO; IN-VIVO; INDUCED APOPTOSIS; MOLECULAR TARGETS; P38 MAPK; PHOSPHATASE ACTIVITIES; PROMYELOCYTIC LEUKEMIAS;

PHOSPHORYLATION;

ARSENIC TRIOXIDE; CHECKPOINT KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WIP1 PHOSPHATASE; ANTINEOPLASTIC AGENT; ATM PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; DNA BINDING PROTEIN; ORGANOARSENIC DERIVATIVE; OXIDE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; TP53 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; CELL CYCLE; CELL STRAIN HL 60; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MAP KINASE SIGNALING SYSTEM; OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 49649125637     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800560200     Document Type: Article

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