Metabolic engineering with multi-objective optimization of kinetic models

Journal of Biotechnology

Volumn 222, Issue , 2016, Pages 1-8

  Villaverde, Alejandro F ^a,b,c   Bongard, Sophia ^d   Mauch, Klaus ^d   Balsa Canto, Eva ^a   Banga, Julio R ^a  

^a INSTITUTO DE INVESTIGACIONES MARINAS   (Spain)

^b UNIVERSITY OF MINHO   (Portugal)

^c UNIVERSITY OF VIGO   (Spain)

^d INSILICO Biotechnology GmbH   (Germany)

Author keywords

Dynamic modelling; Large scale; Metabolic engineering; Multi objective optimization; Target identification; Up down regulation

Indexed keywords

BATCH DATA PROCESSING; DYNAMIC MODELS; ECONOMIC AND SOCIAL EFFECTS; KINETIC PARAMETERS; KINETIC THEORY; METABOLIC ENGINEERING; METABOLISM; PRODUCTIVITY;

BIOTECHNOLOGICAL PROCESS; CHINESE HAMSTER OVARY CELLS; DYNAMIC OPTIMIZATION; ENGINEERING APPLICATIONS; ENZYMATIC MODIFICATION; LARGE-SCALE; TARGET IDENTIFICATION; UP/DOWN-REGULATION;

MULTIOBJECTIVE OPTIMIZATION;

AMMONIA; LACTIC ACID; ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; BATCH PROCESS; BIOMASS PRODUCTION; CELL GROWTH; CHO CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME MODIFICATION; FEMALE; KINETICS; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BIOTECHNOLOGY; CRICETULUS; HAMSTER; METABOLISM; METHODOLOGY; PROCEDURES;

ANIMALS; ANTIBODIES; BIOTECHNOLOGY; CHO CELLS; CRICETINAE; CRICETULUS; KINETICS; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; RESEARCH DESIGN;

EID: 84957567940     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2016.01.005     Document Type: Article

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