Effect of triclosan, triclocarban, 2,2',4,4'-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis

Toxicology in Vitro

Volumn 32, Issue , 2016, Pages 310-319

  Wu, Yuanfeng ^a   Beland, Frederick A ^a   Fang, Jia Long ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Iodide uptake; Thyroid disruptors; Thyroid hormone synthesis; Thyroid peroxidase

Indexed keywords

2,2',4,4' TETRABROMODIPHENYL ETHER; 4,4' ISOPROPYLIDENEDIPHENOL; SODIUM IODIDE; SODIUM IODIDE SYMPORTER; THYROID PEROXIDASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXE1; TRANSCRIPTION FACTOR NKX2 1; TRANSCRIPTION FACTOR PAX8; TRICLOCARBAN; TRICLOSAN; UNCLASSIFIED DRUG; 2,2',4,4'-TETRABROMODIPHENYL ETHER; BENZHYDRYL DERIVATIVE; CARBANILIDE DERIVATIVE; COTRANSPORTER; DIPHENYL ETHER DERIVATIVE; ENDOCRINE DISRUPTOR; FORKHEAD TRANSCRIPTION FACTOR; FOXE1 PROTEIN, RAT; IODIDE; IODIDE PEROXIDASE; NUCLEAR PROTEIN; PAX8 PROTEIN, RAT; PHENOL DERIVATIVE; THYROGLOBULIN; THYROID HORMONE; THYROID NUCLEAR FACTOR 1;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FOXE1 GENE; GENE; GENE EXPRESSION REGULATION; IN VITRO STUDY; IODIDE UPTAKE; ION TRANSPORT; MICROSOME; NKX2 1 GENE; NONHUMAN; PAX8 GENE; RAT; SLC5A5 GENE; THYROID FOLLICLE CELL; THYROID HORMONE SYNTHESIS; TPO GENE; TPO GENEG; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; MALE; METABOLISM; THYROID FOLLICULAR CELL; WISTAR RAT;

ANIMALS; BENZHYDRYL COMPOUNDS; CARBANILIDES; CELL LINE; CELL SURVIVAL; ENDOCRINE DISRUPTORS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HALOGENATED DIPHENYL ETHERS; IODIDE PEROXIDASE; IODIDES; MALE; MICROSOMES; NUCLEAR PROTEINS; PAX8 TRANSCRIPTION FACTOR; PHENOLS; RATS, WISTAR; SYMPORTERS; THYROGLOBULIN; THYROID EPITHELIAL CELLS; THYROID HORMONES; TRANSCRIPTION FACTORS; TRICLOSAN;

EID: 84957559064     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.01.014     Document Type: Article

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