Dose-response assessment of the dermal toxicity of triclosan in B6C3F1 mice

Toxicology Research

Volumn 4, Issue 4, 2015, Pages 867-877

  Fang, Jia Long ^a   Vanlandingham, Michelle ^a   Juliar, Beth E ^a   Olson, Greg ^a   Patton, Ralph E ^a   Beland, Frederick A ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; THYROXINE; TRICLOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B6C3F1 MOUSE; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DERMATITIS; DISEASE SEVERITY; DOSE RESPONSE; DRUG MEGADOSE; EPIDERMIS HYPERPLASIA; ESTRUS CYCLE; FEMALE; GENDER; LIVER HYPERTROPHY; LIVER WEIGHT; LOW DRUG DOSE; LYMPHOID HYPERPLASIA; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; PARAKERATOSIS; PRIORITY JOURNAL; RETICULOCYTE COUNT; SKIN DEFECT; SKIN FIBROSIS; SKIN NECROSIS; SKIN TOXICITY; SKIN ULCER; SPERMATOZOON COUNT; THYROXINE BLOOD LEVEL; WEIGHT CHANGE;

MUS;

EID: 84934990792     PISSN: 2045452X     EISSN: 20454538     Source Type: Journal    
DOI: 10.1039/c4tx00152d     Document Type: Article

References (54)

1. J. V. Rodricks J. A. Swenberg J. F. Borzelleca R. R. Maronpot A. M. Shipp Triclosan: a critical review of the experimental data and development of margins of safety for consumer products Crit. Rev. Toxicol. 2010 40 422 484
2. R. D. Jones H. B. Jampani J. L. Newman A. S. Lee Triclosan: a review of effectiveness and safety in health care settings Am. J. Infect. Control 2000 28 184 196
3. J.-L. Fang R. L. Stingley F. A. Beland W. Harrouk D. L. Lumpkins P. Howard Occurrence, efficacy, metabolism, and toxicity of triclosan J. Environ. Sci. Health C 2010 28 147 171
4. M. Adolfsson-Erici M. Pettersson J. Parkkonen J. Sturve Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden Chemosphere 2002 46 1485 1489
5. D. W. Kolpin E. T. Furlong M. T. Meyer E. M. Thurman S. D. Zaugg L. B. Barber H. T. Buxton Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance Environ. Sci. Technol. 2002 36 1202 1211
6. A. Lindström I. J. Buerge T. Poiger P.-A. Bergqvist M. D. Müller H.-R. Buser Occurrence and environmental behavior of the bactericide triclosan and its methyl derivative in surface waters and in wastewater Environ. Sci. Technol. 2002 36 2322 2329
7. H. Singer S. Müller C. Tixier L. Pillonel Triclosan: occurrence and fate of a widely used biocide in the aquatic environment: field measurements in wastewater treatment plants, surface waters, and lake sediments Environ. Sci. Technol. 2002 36 4998 5004
8. G. A. Loraine M. E. Pettigrove Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in Southern California Environ. Sci. Technol. 2006 40 687 695
9. A. M. Calafat X. Ye L.-Y. Wong J. A. Reidy L. L. Needham Urinary concentrations of triclosan in the U.S. population: 2003-2004 Environ. Health Perspect. 2008 116 303 307
10. M. Allmyr M. Adolfsson-Erici M. S. McLachlan G. Sandborgh-Englund Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products Sci. Total Environ. 2006 372 87 93
11. G. Sandborgh-Englund M. Adolfsson-Erici G. Odham J. Ekstrand Pharmacokinetics of triclosan following oral ingestion in humans J. Toxicol. Environ. Health A 2006 69 1861 1873
12. L. Hovander T. Malmberg M. Athanasiadou I. Athanassiadis S. Rahm Å. Bergman E. Klasson Wehler Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma Arch. Environ. Contam. Toxicol. 2002 42 105 117
13. A. D. Dayan Risk assessment of triclosan [Irgasan®] in human breast milk Food Chem. Toxicol. 2007 45 125 129
14. Y. J. Lin Buccal absorption of triclosan following topical mouthrinse application Am. J. Dent. 2000 13 215 217
15. D. M. Bagley Y. J. Lin Clinical evidence for the lack of triclosan accumulation from daily use in dentifrices Am. J. Dent. 2000 13 148 152
16. P. Chedgzoy G. Winckle C. M. Heard Triclosan: release from transdermal adhesive formulations and in vitro permeation across human epidermal membranes Int. J. Pharm. 2002 235 229 236
17. T. Moss D. Howes F. M. Williams Percutaneous penetration and dermal metabolism of triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether) Food Chem. Toxicol. 2000 38 361 370
18. L.-Q. Wang C. N. Falany M. O. James Triclosan as a substrate and inhibitor of 3′-phosphoadenosine 5′-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions Drug Metab. Dispos. 2004 32 1162 1169
19. J.-L. Fang M. M. Vanlandingham G. Gamboa da Costa F. A. Beland Absorption and metabolism of triclosan after application to the skin of B6C3F1 mice Environ. Toxicol. 2014 10.1002/tox.22074
20. M. Th. M. Tulp G. Sundström L. B. J. M. Martron O. Hutzinger Metabolism of chlorodiphenyl ethers and Irgasan® DP 300 Xenobiotica 1979 9 65 77
21. S. J. DeSalva B. M. Kong Y. J. Lin Triclosan: a safety profile Am. J. Dent. 1989 2 185 196
22. F. L. Lyman T. Furia Toxicology of 2, 4, 4′-trichloro-2′-hydroxy-diphenyl ether IMS Ind. Med. Surg. 1969 38 64 71
23. J. M. Burns, M. R. Moore, D. Dehler, J. F. Arrington Jr., R. Ridgway, A. K. Thakur, M. Smyth, N. M. Centanni, M. F. Palmer and A. Hassan, 14-Day repeated dose dermal study of triclosan in CD-1 mice (CHV2763-100). FDA Docket 1975N-0183H, OTC Volume Number 120, 2001
24. J. M. Burns, M. R. Moore, D. Dehler, J. F. Arrington Jr., R. Ridgway, A. K. Thakur, M. Smyth, N. M. Centanni, M. F. Palmer and A. Hassan, 14-Day repeated dose dermal study of triclosan in mice (CHV6718-101). FDA Docket 1975N-0183H, OTC Volume Number 119, 2001
25. K. B. Delclos L. Camacho S. M. Lewis M. M. Vanlandingham J. R. Latendresse G. R. Olson K. J. Davis R. E. Patton G. Gamboa da Costa K. A. Woodling M. S. Bryant M. Chidambaram R. Trbojevich B. E. Juliar R. P. Felton B. T. Thorn Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90 Toxicol. Sci. 2014 139 174 197
26. D. Torous N. Asano C. Tometsko S. Sugunan S. Dertinger T. Morita M. Hayashi Performance of flow cytometric analysis for the micronucleus assay-a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood Mutagenesis 2006 21 11 13
27. S. D. Dertinger D. K. Torous N. E. Hall F. G. Murante S. E. Gleason R. K. Miller C. R. Tometsko Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer Mutat. Res. 2002 515 3 14
28. D. K. Torous N. E. Hall F. G. Murante S. E. Gleason C. R. Tometsko S. D. Dertinger Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy Toxicol. Sci. 2003 74 309 314
29. C. W. Dunnett A multiple comparison procedure for comparing several treatments with a control J. Am. Stat. Assoc. 1955 50 1096 1121
30. E. Brunner, S. Domhof and F. Langer, Nonparametric Analysis of Longitudinal Data in Factorial Experiments, John Wiley & Sons, Inc., New York, 2002
31. Y. Hochberg A sharper Bonferroni procedure for multiple tests of significance Biometrika 1988 75 800 802
32. M. G. Kenward J. H. Roger Small sample inference for fixed effects from restricted maximum likelihood Biometrics 1997 53 983 997
33. S. Holm A simple sequentially rejective multiple test procedure Scand. J. Stat. 1979 6 65 70
34. A. J. Bailer C. J. Portier Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples Biometrics 1988 44 417 431
35. G. S. Bieler R. L. Williams Ratio estimates, the delta method, and quantal response tests for increased carcinogenicity Biometrics 1993 49 793 801
36. A. Agresti, Categorical Data Analysis, John Wiley & Sons, Inc., New York, 2nd edn., 2002
37. A. R. Jonckheere A distribution-free k-sample test against ordered alternatives Biometrika 1954 41 133 145
38. T. J. Terpstra The asymptotic normality and consistency of Kendall's test against trend, when ties are present in one ranking Indagationes Mathematicae 1952 14 327 333
39. E. Shirley A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment Biometrics 1977 33 386 389
40. D. A. Williams A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control Biometrics 1986 42 183 186
41. M. P. McGarry, C. A. Protheroe and J. J. Lee, Mouse Hematology: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2010
42. G. W. Trimmer, K. A. Hostetler, R. D. Phillips, R. C. Forgash, E. R. Frank, M. A. Elliott, E. E. Lonardo, D. J. Letinski, J. E. Stillman, J. R. Jackson, J. L. McGrath, R. L. Harris, C. F. Morris and J. M. Clinton, 90-Day subchronic dermal toxicity study in the rat with satellite group with Irgasan DP300 (MRD-92-399). FDA Docket 1975N-0183H, OTC Volume Number 116, 1994
43. Y. Wu F. A. Beland S. Chen J.-L. Fang Extracellular signal-regulated kinases 1/2 and Akt contribute to triclosan-stimulated proliferation of JB6 Cl 41-5a cells Arch. Toxicol. 2014 10.1007/s00204-014-1308-5
44. Y. Wu Q. Wu F. A. Beland P. Ge M. G. Manjanatha J.-L. Fang Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha Toxicol. Lett. 2014 231 17 28
45. P. I. S. Pinto E. M. Guerreiro D. M. Power Triclosan interferes with the thyroid axis in the zebrafish (Danio rerio) Toxicol. Res. 2013 2 60 69
46. K. M. Crofton K. B. Paul M. J. DeVito J. M. Hedge Short-term in vivo exposure to the water contaminant triclosan: evidence for disruption of thyroxine Environ. Toxicol. Pharmacol. 2007 24 194 197
47. K. B. Paul J. M. Hedge R. Bansal R. T. Zoeller R. Peter M. J. DeVito K. M. Crofton Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action Toxicology 2012 300 31 45
48. K. B. Paul J. M. Hedge M. J. DeVito K. M. Crofton Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats Environ. Toxicol. Chem. 2010 29 2840 2844
49. K. B. Paul J. M. Hedge M. J. DeVito K. M. Crofton Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young Long-Evans rats Toxicol. Sci. 2010 113 367 379
50. L. M. Zorrilla E. K. Gibson S. C. Jeffay K. M. Crofton W. R. Setzer R. L. Cooper T. E. Stoker The effects of triclosan on puberty and thyroid hormones in male Wistar rats Toxicol. Sci. 2009 107 56 64
51. A. B. Dann A. Hontela Triclosan: environmental exposure, toxicity and mechanisms of action J. Appl. Toxicol. 2011 31 285 311
52. B. Liu Y. Wang K. L. Fillgrove V. E. Anderson Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells Cancer Chemother. Pharmacol. 2002 49 187 193
53. B. Schmid J. F. Rippmann M. Tadayyon B. S. Hamilton Inhibition of fatty acid synthase prevents preadipocyte differentiation Biochem. Biophys. Res. Commun. 2005 328 1073 1082
54. L.-W. Guo Q. Wu B. Green G. Nolen L. Shi J. LoSurdo H. Deng S. Bauer J.-L. Fang B. Ning Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells Toxicol. Appl. Pharmacol. 2012 262 117 123