Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways

Toxicology and Applied Pharmacology

Volumn 260, Issue 1, 2012, Pages 81-88

  Vickers, Alison E M ^a   Heale, Jason ^a   Sinclair, John R ^a   Morris, Stephen ^a   Rowe, Josh M ^a   Fisher, Robyn L ^b  

^a ALLERGAN INC   (United States)

^b Vitron Inc   (United States)

Author keywords

Human; Rat; Thyroid

Indexed keywords

CATHEPSIN B; IODIDE PEROXIDASE; MEGALIN; PROPYLTHIOURACIL; SODIUM IODIDE SYMPORTER; THIAMAZOLE; THIOUREA; THYROGLOBULIN; THYROID HORMONE; THYROID PEROXIDASE; THYROTROPIN RECEPTOR;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; GENE EXPRESSION; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; SINGLE DRUG DOSE; THYROID FUNCTION; TISSUE CULTURE; TISSUE SLICE; UPREGULATION;

ADOLESCENT; ADULT; ANIMALS; ANTITHYROID AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; METHIMAZOLE; MIDDLE AGED; PROPYLTHIOURACIL; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; THYROID FUNCTION TESTS; THYROID GLAND; THYROID HORMONES; TIME FACTORS; TISSUE CULTURE TECHNIQUES; UP-REGULATION; YOUNG ADULT;

RATTUS; RODENTIA;

EID: 84858297877     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.029     Document Type: Article

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