Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole

Aquatic Toxicology

Volumn 126, Issue , 2013, Pages 128-136

  Tietge, Joseph E ^a   Degitz, Sigmund J ^a   Haselman, Jonathan T ^a   Butterworth, Brian C ^a   Korte, Joseph J ^a   Kosian, Patricia A ^a   Lindberg Livingston, Annelie J ^a   Burgess, Emily M ^b   Blackshear, Pamela E ^c   Hornung, Michael W ^a  

^a National Health and Environmental Effects Research Laboratory   (United States)

^b Student Contractor Services   (United States)

^c INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

2 Mercaptobenzothiazole; Sodium iodide symporter; Thyroid peroxidase; Thyroid stimulating hormone; Xenopus laevis

Indexed keywords

2 MERCAPTOBENZOTHIAZOLE; DIIODOTYROSINE; IODIDE; IODOTYROSINE; LIOTHYRONINE; SODIUM IODIDE SYMPORTER; THYROID PEROXIDASE; THYROTROPIN; THYROXINE;

AMINO ACID; CHEMICAL POLLUTANT; ENDOCRINE DISRUPTOR; ENZYME ACTIVITY; GENE EXPRESSION; HISTOLOGY; HORMONE; INHIBITION; POLLUTION EFFECT; POLLUTION EXPOSURE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; ENZYME INHIBITION; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LARVAL STAGE; METAMORPHOSIS; NONHUMAN; PRIORITY JOURNAL; THYROID HORMONE SYNTHESIS; TOXICITY TESTING; XENOPUS LAEVIS;

ANIMALS; BENZOTHIAZOLES; ENZYME ACTIVATION; IODIDE PEROXIDASE; METAMORPHOSIS, BIOLOGICAL; SURVIVAL ANALYSIS; THYROID HORMONES; WATER; WATER POLLUTANTS, CHEMICAL; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 84869876503     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2012.10.013     Document Type: Article

References (26)

1. Ankley G.T., Bennett R.S., Erickson R.J., Hoff D.J., Hornung M.W., Johnson R.D., Mount D.R., Nichols J.W., Russom C.L., Schmieder P.K., Serrrano J.A., Tietge J.E., Villeneuve D.L. Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environmental Toxicology and Chemistry 2010, 29:730-741.
2. Boas M., Feldt-Rasmussen U., Skakkebæk N.E., Main K.M. Environmental chemicals and thyroid function. European Journal of Endocrinology 2006, 154:599-611.
3. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998, 8:827-856.
4. Capen C.C. Mechanisms of chemical injury of thyroid gland. Progress in Clinical and Biological Research 1994, 387:173-191.
5. Chang H.C., Doerge D.R. Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. Toxicology and Applied Pharmacology 2000, 168:244-252.
6. Degitz S.J., Holcombe G.W., Flynn K.M., Kosian P.A., Korte J.J., Tietge J.E. Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis: organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine. Toxicological Sciences 2005, 87:353-364.
7. DeVito M., Biegel L., Brouwer A., Brown S., Brucker-Davis F., Cheek A.O., Christensen R., Colborn T., Cooke P., Crissman J., Crofton K., Doerge D., Gray E., Hauser P., Hurley P., Kohn M., Lazar J., McMaster S., McClain M., McConnell E., Meier C., Miller R., Tietge J., Tyl R. Screening methods for thyroid hormone disruptors. Environmental Health Perspectives 1999, 107:407-415.
8. El Dareer S.M., Kalin J.R., Tillery K.F., Hill D.L., Barnett J.W. Disposition of 2-mercaptobenzothiazole and 2-mercaptobenzothiazole disulfide in rats dosed intravenously, orally, and topically and in guinea pigs dosed topically. Journal of Toxicology and Environment Health 1989, 27:65-84.
9. Fort D.J., Degitz S., Tietge J., Touart L.W. The hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction. Critical Reviews in Toxicology 2007, 37:117-161.
10. Grim K.C., Wolfe M., Braunbeck T., Iguchi T., Ohta Y., Tooi O., Touart L., Wolf D.C., Tietge J.E. Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances. Toxicologic Pathology 2009, 37:415-424.
11. Hosoya T., Ui N. Demonstration of some properties of peroxidase in pig thyroid gland. Nature 1961, 192:659-660.
12. Korte J.J., Sternberg R.M., Serrano J.A., Thoemke K.R., Moen S.M., Lillegard K.E., Hornung M.W., Tietge J.E., Degitz S.J. Thyroid-stimulating hormone (TSH): measurement of intracellular, secreted, and circulating hormone in Xenopus laevis and Xenopus tropicalis. General and Comparative Endocrinology 2011, 171:319-325.
13. Nieuwkoop P.D., Faber J. Normal Table of Xenopus laevis (Daudin): A Systematical and Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis 1994, Garland, New York, NY, USA. third ed.
14. National Research Council Toxicity Testing in the 21st Century: A Vision and a Strategy 2007, National Academies Press, Washington, DC.
15. Opitz R., Trubiroha A., Lorenz C., Lutz I., Hartmann S., Blank T., Braunbeck T., Kloas W. Expression of sodium-iodide symporter mRNA in the thyroid gland of Xenopus laevis tadpoles: developmental expression, effects of antithyroidal compounds, and regulation by TSH. Journal of Endocrinology 2006, 190:157-170.
16. Opitz R., Schmidt F., Braunbeck T., Wuertz S., Kloas W. Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis. Molecular and Cellular Endocrinology 2009, 298:101-114.
17. Organization for Economic Cooperation and Development (OECD), 2007. Guidance Document on Amphibian Thyroid Histology. Environmental Health and Safety Publications. Series on Testing and Assessment. No. 82. Paris.
18. Organization for Economic Cooperation and Development (OECD), 2009. Test No. 231: Amphibian Metamorphosis Assay, OECD Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems, No. 100. OECD Publishing.
19. Ruf J., Carayon P. Structural and functional aspects of thyroid peroxidase. Archives of Biochemistry and Biophysics 2006, 445:269-277.
20. Schmutzler C., Gotthardt I., Hofmann P.J., Radovic B., Kovacs G., Stemmler L., Nobis I., Bacinski A., Mentrup B., Ambrugger P., Grüters A., Malendowicz L.K., Christoffel J., Jarry H., Seidlovà-Wuttke D., Wuttke W., Köhrle J. Endocrine disruptors and the thyroid gland-a combined in vitro and in vivo analysis of potential new biomarkers. Environmental Health Perspectives 2007, 115:77-83.
21. Sternberg R.M., Thoemke K.R., Korte J.J., Moen S.M., Olson J.M., Korte L.M., Tietge J.E., Degitz S.J. Control of pituitary thyroid-stimulating hormone synthesis and secretion by thyroid hormones during Xenopus metamorphosis. General and Comparative Endocrinology 2011, 173:428-437.
22. Tietge J.E., Holcombe G.W., Flynn K.M., Kosian P.A., Korte J.J., Anderson L.E., Wolf D.C., Degitz S.J. Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology. Environmental Toxicology and Chemistry 2005, 24:926-933.
23. Tietge J.E., Butterworth B.C., Haselman J.T., Holcombe G.W., Hornung M.W., Korte J.J., Kosian P.A., Wolfe M., Degitz S.J. Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis. Aquatic Toxicology 2010, 98:44-50.
24. U.S. Environmental Protection Agency (U.S. EPA), 1994. Reregistration Eligibility Decision (RED) Sodium and Zinc Salts of 2-Mercaptobenzothiazole. EPA 738-R-94-027. Washington, DC.
25. U.S. Environmental Protection Agency (U.S. EPA), 2009. Endocrine Disruptor Screening Program (EDSP), Announcing the Availability of the Tier 1 Screening Battery and Related Test Guidelines; Notice (74 FR 54415). Docket No. EPA-HQ-OPPT-2008-0521.
26. U.S. National Toxicology Program (U.S. NTP), 1988. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole in F344/N Rats and B6C3F1 Mice. Technical Report 332. NIH Publication No. 88-2588. Washington, DC.