Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression Involved in thyroid hormone metabolism in male rat pups

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 27-39

  Szabo, David T ^a   Richardson, Vicki M ^b   Ross, David G ^b   Diliberto, Janet J ^b   Kodavanti, Prasada R S ^b   Birnbaum, Linda S ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Flame retardant; Hepatic metabolism; PBDE; Rat; Thyroid

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CORN OIL; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2D1; CYTOCHROME P450 3A1; DIBENZOFURAN; DIOXIN; DIPHENYL ETHER DERIVATIVE; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 2B7; LIVER ENZYME; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; POLYBROMINATED DIPHENYL ETHER; PREALBUMIN; PREGNANE X RECEPTOR; SULFOTRANSFERASE 1A1; THYROID HORMONE; THYROXINE; THYROXINE DEIODINASE;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; CHEMICAL COMPOSITION; CONTROLLED STUDY; DEIODINATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GESTATION PERIOD; GLUCURONIDATION; HORMONAL REGULATION; LONG EVANS RAT; LONG TERM EXPOSURE; MALE; NONHUMAN; PERINATAL PERIOD; PROGENY; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; SULFATION; THYROID DISEASE; THYROID HORMONE METABOLISM; THYROXINE BLOOD LEVEL;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ARYL HYDROCARBON HYDROXYLASES; FEMALE; FLAME RETARDANTS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCURONOSYLTRANSFERASE; HALOGENATED DIPHENYL ETHERS; MALE; MICROSOMES, LIVER; PREGNANCY; RATS; RATS, LONG-EVANS; SULFOTRANSFERASES; THYROXINE; TRIIODOTHYRONINE;

RATTUS; ZEA MAYS;

EID: 58049195678     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn230     Document Type: Article

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