Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling

EMBO Journal

Volumn 35, Issue 3, 2016, Pages 319-334

  Santos, Celio X C ^a   Hafstad, Anne D ^a,b   Beretta, Matteo ^a   Zhang, Min ^a   Molenaar, Chris ^a   Kopec, Jola ^a   Fotinou, Dina ^a   Murray, Thomas V ^a   Cobb, Andrew M ^a   Martin, Daniel ^a   Zeh Silva, Maira ^a   Anilkumar, Narayana ^a   Schröder, Katrin ^c   Shanahan, Catherine M ^a   Brewer, Alison C ^a   Brandes, Ralf P ^c   Blanc, Eric ^d   Parsons, Maddy ^a   Belousov, Vsevelod ^e   Cammack, Richard ^f   Hider, Robert C ^f   Steiner, Roberto A ^a   Shah, Ajay M ^a   more..

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TROMSØ   (Norway)

^c GOETHE UNIVERSITY   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

eIF2 ; metal center; Nox4; protein phosphatase; redox signaling

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; HISTONE H3; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN; PROTEIN GADD 34; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; THIOL; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; INITIATION FACTOR 2; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR; NOX4 PROTEIN, HUMAN; PPP1R15A PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ACUTE KIDNEY FAILURE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYTIC EFFICIENCY; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN UNFOLDING; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION;

ANIMALS; CELL LINE; EUKARYOTIC INITIATION FACTOR-2; HUMANS; NADPH OXIDASE; OXIDATION-REDUCTION; PROTEIN PHOSPHATASE 1; RECEPTORS, NEUROPEPTIDE Y; SIGNAL TRANSDUCTION;

EID: 84957438803     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201592394     Document Type: Article

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