An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease

Alzheimer's Research and Therapy

Volumn 8, Issue 1, 2016, Pages

  Elkahloun, Abdel G ^a   Hafko, Roman ^b   Saavedra, Juan M ^b,c  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Angiotensin II receptor blockers; GEO database; Glutamate excitotoxicity; GSEA; IPA analysis; Neurodegenerative disorders; Neuroprotection

Indexed keywords

CANDESARTAN; CAPTOPRIL; GLUTAMIC ACID; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; AUTACOID; BENZIMIDAZOLE DERIVATIVE; NEUROPROTECTIVE AGENT; TETRAZOLE DERIVATIVE; TRANSCRIPTOME;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DORSOLATERAL PREFRONTAL CORTEX; DOWN REGULATION; ENDOTHELIUM CELL; EXCITOTOXICITY; GRANULE CELL; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MICROARRAY ANALYSIS; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION; AGED; ANIMAL; APOPTOSIS; CELL CULTURE; CEREBELLUM; DISEASE MODEL; DRUG EFFECTS; FACTUAL DATABASE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; APOPTOSIS; BENZIMIDAZOLES; CELLS, CULTURED; CEREBELLUM; DATABASES, FACTUAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; INFLAMMATION MEDIATORS; NEURONS; NEUROPROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TETRAZOLES; TRANSCRIPTOME;

EID: 84956936161     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/s13195-015-0167-5     Document Type: Article

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