Endothelin-1 is Elevated in Alzheimer's Disease and Upregulated by Amyloid-β

Journal of Alzheimer's Disease

Volumn 29, Issue 4, 2012, Pages 853-861

  Palmer, Jennifer C ^a   Barker, Rachel ^a   Kehoe, Patrick G ^a   Love, Seth ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Alzheimer's disease; amyloid ; cerebral ischemia; cerebrovascular circulation; cerebrovascular disorders; endothelin 1; vasoconstriction

Indexed keywords

AMYLOID BETA PROTEIN; ENDOTHELIN 1; MESSENGER RNA; PARAFFIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD VESSEL; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; NEOCORTEX; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SUPERNATANT; TEMPORAL CORTEX; TISSUE HOMOGENATE; UPREGULATION;

EID: 84860165011     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-111760     Document Type: Article

References (57)

1. Dekosky ST, Shih WJ, Schmitt FA, Coupal. J, Kirkpatrick C (1990) Assessing utility of single photon emission computed tomography spect scan in Alzheimer disease correlation with cognitive severity. Alzheimer Dis Assoc Disord 4, 14-23. (Pubitemid 20311746)
2. Imran MB, Kawashima R, Awata S, Sato K, Kinomura S, Ono S, Sato M, Fukuda H (1999) Tc-99m HMPAO SPECT in the evaluation of Alzheimer's disease: Correlation between neu-ropsychiatric evaluation and CBF images. J Neurol Neurosurg Psychiatry 66, 228-232. (Pubitemid 29103528)
3. Shiraishi H, Chang CC, Kanno H, Yamamoto I (2004) The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology. J Clin Neurosci 11, 138-141. (Pubitemid 38248411)
4. de la Torre JC (2005) Is Alzheimer's disease preceded by neurodegeneration or cerebral hypoperfusion? Ann Neurol 57, 783-784. (Pubitemid 40798614)
5. Ruitenberg A, Heijer Td, Bakker SLM, Swieten JCv, Koudstaal PJ, Hofman A, Breteler MMB (2005) Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study. Ann Neurol 57, 789-794. (Pubitemid 40798616)
6. Dickstein DL, Walsh J, Brautigam H, Stockton SD, Gandy S, Hof PR (2010) Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. Mt Sinai J Med 77, 82-102.
7. Kedzierski RM, Yanagisawa M (2001) Endothelin system: The double-edged sword in health and disease. Annu Rev Pharmacol Toxicol 41, 851-876. (Pubitemid 32385909)
8. Blais V, Fugere M, Denault JB, Klarskov K, Day R, Leduc R (2002) Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family. FEBS Lett 524, 43-48. (Pubitemid 34804832)
9. Yanagisawa H, Hammer RE, Richardson JA, Emoto N, Williams SC, Takeda S, Clouthier DE, Yanagisawa M (2000) Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest 105, 1373-1382. (Pubitemid 30322403)
10. Simard E, Jin DN, Takai S, Miyazaki M, Brochu I, D'Orleans-Juste P (2009) Chymase-dependent conversion of big endothelin-1 in the mouse in vivo. J Pharmacol Exp Ther 328, 540-548.
11. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 82, 239-259.
12. Pearson HA, Peers C (2006) Physiological roles for amyloid-P peptides. J Physiol Lond 575, 5-10.
13. Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective. Cell 120, 545-555. (Pubitemid 40269768)
14. Shankar GM, Li SM, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-fj protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14, 837-842.
15. Wang J, Dickson DW, Trojanowski JQ, Lee VMY (1999) The levels of soluble versus insoluble brain Afj distinguish Alzheimer's disease from normal and pathologic aging. Exp Neurol 158, 328-337. (Pubitemid 29382824)
16. Niwa K, Porter VA, Kazama K, Cornfield D, Carlson GA, Iadecola C (2001) Afj-peptides enhance vasoconstriction in cerebral circulation. Am J Physiol Heart Circ Physiol 281, H2417-H2424.
17. Gentile MT, Vecchione C, Maffei A, Aretini A, Marino G, Poulet R, Capobianco L, Selvetella G, Lembo G (2004) Mechanisms of soluble fj-amyloid impairment of endothelial function. J Biol Chem 279, 48135-48142. (Pubitemid 39540968)
18. Palmer JC, Kehoe PG, Love S (2010) Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia. Neuropathol Appl Neurobiol 36, 487-497.
19. Palmer JC, Baig S, Kehoe PG, Love S (2009) Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Afj. Am J Pathol 175, 262-270.
20. Eckman EA, Watson M, Marlow L, Sambamurti K, Eck-man CB (2003) Alzheimer's disease fj-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J Biol Chem 278, 2081-2084. (Pubitemid 36801269)
21. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT method. Methods 25, 402-408. (Pubitemid 34164012)
22. van Helmond Z, Heesom K, Love S (2009) Characterisation of two antibodies to oligomeric Afj and their use in ELISAs on human brain tissue homogenates. JNeurosci Methods 176, 206-212.
23. Lambert MP, Stevens G, Sabo S, Barber K, Wang G, Wade W, Krafft G, Snyder S, Holzman TF, Klein WL (1994) p/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma-cells. J Neurosci Res 39, 377-385. (Pubitemid 24348291)
24. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SKF (1996) fj-Amyloid induces apoptosis in human-derived neu-rotypic SH-SY5Y cells. Brain Res 738, 196-204. (Pubitemid 26378912)
25. Dashwood MR, Loesch A (2010) Endothelin-1 as a neuropeptide: Neurotransmitter or neurovascular effects? J Cell Commun Signal 4, 51-62.
26. Giaid A, Gibson SJ, Herrero MT, Gentleman S, Legon S, Yanagisawa M, Masaki T, Ibrahim NBN, Roberts GW, Rossi ML, Polak JM (1991) Topographical localization of endothelin messenger-RNA and peptide immunoreactivity in neurons of the human brain. Histochemistry 95, 303-314.
27. Lee ME, Delamonte SM, Ng SC, Bloch KD, Quertermous T (1990) Expression of the potent vasoconstrictor endothelin in the human central-nervous-system. J Clin Invest 86, 141-147. (Pubitemid 20226986)
28. Takahashi K, Ghatei MA, Jones PM, Murphy JK, Lam HC, Ohalloran DJ, Bloom SR (1991) Endothelin in human brain and pituitary-gland-comparison with rat. J Cardiovasc Pharmacol 17, S101-S103.
29. Naidoo V, Naidoo S, Mahabeer R, Raidoo DM (2004) Cellular distribution of the endothelin system in the human brain. J Chem Neuroanat 27, 87-98. (Pubitemid 38581104)
30. Naidoo V, Naidoo S, Raidoo DM (2004) Immunolocalisation of endothelin-1 in human brain. J Chem Neuroanat 27, 193-200. (Pubitemid 38739358)
31. Kuwaki T, Cao WH, Kumada M (1994) Endothelin in the brain and its effect on central control of the circulation and other functions. Jpn J Physiol 44, 1-18. (Pubitemid 24126740)
32. Minami M, Kimura M, Iwamoto N, Arai H (1995) Endothelin-1-like immunoreactivity in cerebral-cortex of Alzheimer-type dementia. Prog Neuropsychopharmacol Biol Psychiatry 19, 509-513.
33. Luo JH, Grammas P (2010) Endothelin-1 is elevated in Alzheimer's disease brain microvessels and is neuroprotective. J Alzheimers Dis 21, 887-896.
34. Deane R, Yan SD, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B (2003) RAGE mediates amyloid-fj peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 9, 907-913. (Pubitemid 36889934)
35. Edvinsson L (2009) Cerebrovascular endothelin receptor upregulation in cerebral ischemia. Curr Vasc Pharmacol 7, 26-33.
36. Loesch A (2005) Localisation of endothelin-1 and its receptors in vascular tissue as seen at the electron microscopiclevel. Curr Vasc Pharmacol 3, 381-392. (Pubitemid 41264291)
37. Milner P, Loesch A, Burnstock G (2000) Neural endothelin in hypertension: Increased expression in ganglia and nerves to cerebral arteries of the spontaneously hypertensive rat. J Vasc Res 37, 39-49. (Pubitemid 30158040)
38. Chisari M, Merlo S, Sortino MA, Salomone S (2010) Long-term incubation with fj-amyloid peptides impairs endothelium-dependent vasodilatation in isolated rat basilar artery. Pharmacol Res 61, 157-161.
39. Palmer J, Love S (2011) Endothelin receptor antagonists: Potential in Alzheimer's disease. Pharmacol Res 63, 525-531.
40. Cameron NE, Dines KC, Cotter MA (1994) The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats. Diabetologia 37, 1209-1215. (Pubitemid 24356760)
41. Stevens EJ, Tomlinson DR (1995) Effects of endothelin receptor antagonism with bosentan on peripheral-nerve function in experimental diabetes. Br J Pharmacol 115, 373-379.
42. Silva AC, Lee SP, Iadecola C, Kim SG (2000) Early temporal characteristics of cerebral blood flow and deoxyhemoglobin changes during somatosensory stimulation. J Cereb Blood Flow Metab 20, 201-206. (Pubitemid 30019846)
43. Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5, 347-360. (Pubitemid 38568496)
44. Jagust W, Gitcho A, Sun F, Kuczynski B, Mungas D, Haan M (2006) Brain imaging evidence of preclinical Alzheimer's disease in normal aging. Ann Neurol 59, 673-681.
45. Jagust W, Reed B, Mungas D, Ellis W, DeCarli C (2007) What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia? Neurology 69, 871-877. (Pubitemid 47329586)
46. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang FS, Cole G (1996) Correlative memory deficits, Afj elevation, and amyloid plaques in transgenic mice. Science 274, 99-102. (Pubitemid 26332733)
47. Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D, Iadecola C, Clark HB, Carlson G (1995) Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15, 1203-1218.
48. Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ (2008) Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: Contribution of soluble and insoluble amyloid-fj peptide, partial restoration via-y-secretase inhibition. J Neurosci 28, 13542-13550.
49. Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, Song W (2006) Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci USA 103, 18727-18732. (Pubitemid 44913478)
50. Zhang X, Zhou K, Wang RS, Cui JK, Lipton SA, Liao FF, Xu HX, Zhang YW (2007) Hypoxia-inducible factor 1 a (HIF-1 a)-mediated hypoxia increases BACE1 expression and fj-amyloid generation. J Biol Chem 282, 10873-10880. (Pubitemid 47100783)
51. Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ (2011) Cerebrovascular lesions induce transient fj-amyloid deposition. Brain 134, 3697-3707.
52. Zetterberg H, Mortberg E, Song L, Chang L, Provuncher GK, Patel PP, Ferrell E, Fournier DR, Kan CW, Campbell TG, Meyer R, Rivnak AJ, Pink BA, Minnehan KA, Piech T, Rissin DM, Duffy DC, Rubertsson S, Wilson DH, Blennow K (2011) Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid-fj levels in humans. PLoS One 6, e28263.
53. Oresic M, Hyotylainen T, Herukka SK, Sysi-Aho M, Mattila I, Seppanan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lotjonen J, Soininen H (2011) Metabolome in progression to Alzheimer's disease. Transl Psychiatry 1, e57.
54. De Jong GI, Farkas E, Stienstra CM, Plass JRM, Keijser JN, De la Torre JC, Luiten PGM (1999) Cerebral hypoperfusion yields capillary damage in the hippocampal Ca1 area that correlates with spatial memory impairment. Neuroscience 91, 203-210. (Pubitemid 29170459)
55. DeKosky S (2003) Early intervention is key to successful management of Alzheimer disease. Alzheimer Dis Assoc Disord 17, S99-S104.
56. Jagust W (2004) Molecular neuroimaging in Alzheimer's disease. NeuroRx 1, 206-212. (Pubitemid 46589352)
57. Elesber AA, Bonetti PO, Woodrum JE, Zhu XY, Lerman LO, Younkin SG, Lerman A (2006) Bosentan preserves endothelial function in mice overexpressing APP. Neurobiol Aging 27, 446-450. (Pubitemid 43185330)