Dual Role of the Active Site Residues of Thermus thermophilus 3-Isopropylmalate Dehydrogenase: Chemical Catalysis and Domain Closure

Biochemistry

Volumn 55, Issue 3, 2016, Pages 560-574

  Gráczer, Éva ^a   Szimler, Tamás ^a   Garamszegi, Anita ^a   Konarev, Petr V ^b,f   Lábas, Anikó ^c   Oláh, Julianna ^c   Palló, Anna ^a   Svergun, Dmitri I ^b   Merli, Angelo ^d   Závodszky, Péter ^a   Weiss, Manfred S ^e   Vas, Mária ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^d UNIVERSITY OF PARMA   (Italy)

^e HAHN MEITNER INSTITUT   (Germany)

^f SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ABSTRACTING; ACTIVATION ENERGY; CATALYSIS; CATALYST ACTIVITY; CRYSTAL STRUCTURE; ENZYMES; MOLECULAR DYNAMICS; MOLECULAR MODELING; QUANTUM THEORY; X RAY SCATTERING;

ACTIVE SITE RESIDUES; CRYSTAL STRUCTURE ANALYSIS; ENZYME-SUBSTRATE COMPLEXES; MOLECULAR CONTACTS; MOLECULAR DYNAMICS SIMULATIONS; PROTON-RELAY SYSTEMS; QUANTUM MECHANICS/MOLECULAR MECHANICS; THERMUS THERMOPHILUS;

ENZYME ACTIVITY;

3 ISOPROPYLMALATE DEHYDROGENASE; BACTERIAL PROTEIN;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDRODYNAMICS; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTON TRANSPORT; QUANTUM MECHANICS; STATIC ELECTRICITY; SURFACE CHARGE; TAUTOMERIZATION; THERMUS THERMOPHILUS; TRANSITION TEMPERATURE; X RAY CRYSTALLOGRAPHY; AMINO ACID SUBSTITUTION; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; QUANTUM THEORY; SMALL ANGLE SCATTERING; X RAY;

3-ISOPROPYLMALATE DEHYDROGENASE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROGEN-ION CONCENTRATION; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN STRUCTURE, TERTIARY; QUANTUM THEORY; SCATTERING, SMALL ANGLE; THERMUS THERMOPHILUS; X-RAYS;

EID: 84956746406     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00839     Document Type: Article

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