Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis

FEBS Journal

Volumn 281, Issue 22, 2014, Pages 5063-5076

  Pallõ, Anna ^a,e,f,g   Oláh, Julianna ^b   Gráczer, Éva ^a   Merli, Angelo ^c   Závodszky, Péter ^a   Weiss, Manfred S ^d   Vas, Mária ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^c UNIVERSITY OF PARMA   (Italy)

^d HAHN MEITNER INSTITUT   (Germany)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f Brussels Center for Redox Biology   (Belgium)

^g VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

general base catalysis; isopropylmalate dehydrogenase; oxidative decarboxylation; QM MM calculations; X ray crystallography

Indexed keywords

3 ISOPROPYLMALATE DEHYDROGENASE; BACTERIAL PROTEIN; MAGNESIUM; MALIC ACID DERIVATIVE; MANGANESE; NICOTINAMIDE ADENINE DINUCLEOTIDE; POTASSIUM;

AMINO ACID SEQUENCE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; HYDROGEN BOND; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS; THERMUS THERMOPHILUS; X RAY CRYSTALLOGRAPHY;

3-ISOPROPYLMALATE DEHYDROGENASE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MAGNESIUM; MALATES; MANGANESE; MODELS, MOLECULAR; NAD; POTASSIUM; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; THERMUS THERMOPHILUS;

EID: 84910116408     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13044     Document Type: Article

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