Ligands of the Mn2+ Bound to Porcine Mitochondrial NADP-Dependent Isocitrate Dehydrogenase, as Assessed by Mutagenesis

Biochemistry

Volumn 43, Issue 10, 2004, Pages 2821-2828

  Huang, Yu Chu ^a   Grodsky, Neil B ^a   Kim, Tae Kang ^a   Colman, Roberta F ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; COORDINATION REACTIONS; CRYSTAL ATOMIC STRUCTURE; ENZYMES; IONS; MUTAGENESIS; PH EFFECTS;

DEPROTONATION; MUTANTS;

BIOCHEMISTRY;

ASPARAGINE; ASPARTIC ACID; CADMIUM; COBALT; CYSTEINE; HISTIDINE; HYDROXYL GROUP; ISOCITRATE DEHYDROGENASE; LIGAND; MAGNESIUM; MANGANESE; MITOCHONDRIAL ENZYME; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEPENDENT ISOCITRATE DEHYDROGENASE; UNCLASSIFIED DRUG; DIVALENT CATION; ISOCITRATE DEHYDROGENASE (NADP+); RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; CATALYSIS; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; DEPROTONATION; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HEART MITOCHONDRION; LIGAND BINDING; METAL BINDING; NONHUMAN; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; SWINE; ANIMAL; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; KINETICS;

ESCHERICHIA COLI; SUIDAE; SUS SCROFA;

ANIMALS; ASPARTIC ACID; BINDING SITES; CATIONS, DIVALENT; CIRCULAR DICHROISM; HYDROGEN-ION CONCENTRATION; ISOCITRATE DEHYDROGENASE; KINETICS; LIGANDS; MANGANESE; MITOCHONDRIA, HEART; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; SWINE;

EID: 1542297722     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030253f     Document Type: Article

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