Drugs against Mycobacterium tuberculosis 3-isopropylmalate dehydrogenase can be developed using homologous enzymes as surrogate targets

Protein and Peptide Letters

Volumn 21, Issue 12, 2014, Pages 1295-1307

  Gráczer, Éva ^a   Bacsó, András ^a   Kónya, Dénes ^a   Kazi, Adrián ^a   Soós, Tibor ^a   Molnár, Laura ^a   Szimler, Tamás ^a   Beinrohr, László ^a   Szilágyi, András ^a   Závodszky, Péter ^a   Vas, Mária ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Enzyme kinetics; Expression; Inhibition; Isopropylmalate dehydrogenase; Mycobacterium tuberculosis; Physical chemical characterization; Purification

Indexed keywords

3 ISOPROPYLMALATE DEHYDROGENASE; 3 METHYLMERCAPTOMALATE; ESCHERICHIA COLI 3 ISOPROPYLMALATE DEHYDROGENASE; MYCOBACTERIUM TUBERCULOSIS 3 ISOPROPYLMALATE DEHYDROGENASE; O METHYL OXALOHYDROXAMATE; THERMUS THERMOPHILUS 3 ISOPROPYLMALATE DEHYDROGENASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; TUBERCULOSTATIC AGENT;

ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; ESCHERICHIA COLI; LIGHT SCATTERING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; THERMUS THERMOPHILUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; PH; PROTEIN REFOLDING;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; THERMUS THERMOPHILUS;

3-ISOPROPYLMALATE DEHYDROGENASE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; DRUG DISCOVERY; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PROTEIN REFOLDING;

EID: 84925642604     PISSN: 09298665     EISSN: 18755305     Source Type: Journal    
DOI: None     Document Type: Article

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