An Allosteric Signaling Pathway of Human 3-Phosphoglycerate Kinase from Force Distribution Analysis

PLoS Computational Biology

Volumn 10, Issue 1, 2014, Pages

  Palmai, Zoltan ^a   Seifert, Christian ^b   Gräter, Frauke ^b,c   Balog, Erika ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Heidelberger Institut für Theoretische Studien gGmbH   (Germany)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CATALYST ACTIVITY; ENZYMES; REACTION KINETICS; SUBSTRATES;

3-PHOSPHOGLYCERATE; C-DOMAIN; CONFORMATIONAL CHANGE; DISTRIBUTION ANALYSIS; FORCE DISTRIBUTIONS; PHOSPHATE GROUP; PHOSPHOGLYCERATE KINASE; PHOSPHORYL TRANSFER REACTIONS; SIGNALLING PATHWAYS; TWO DOMAINS;

MOLECULAR DYNAMICS;

GLUTAMIC ACID; GLYCINE; PHOSPHOGLYCERATE KINASE;

ALLOSTERISM; ALPHA HELIX; ANALYSIS; ARTICLE; BINDING SITE; CATALYSIS; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; FORCE DISTRIBUTION ANALYSIS; HINGE REGION; HUMAN; HYDROGEN BOND; MACROMOLECULE; MOLECULAR DYNAMICS; MUTAGENESIS; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALGORITHMS; ALLOSTERIC SITE; BINDING SITES; DNA MUTATIONAL ANALYSIS; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; PHOSPHOGLYCERATE KINASE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 84896727555     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003444     Document Type: Article

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