Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy

Journal of Medicinal Chemistry

Volumn 59, Issue 2, 2016, Pages 487-496

  Rani, Reshma ^a   Kumar, Vinit ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXENONE DERIVATIVE; 2 NAPHTHOIC ACID DERIVATIVE; 2,3 DIHYDROXYNAPHTHOIC ACID DERIVATIVE; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; DIHYDROPYRIMIDINE DERIVATIVE; DIHYDROPYRONE DERIVATIVE; EPIGALLOCATECHIN; FLAVONE DERIVATIVE; GALLIC ACID DERIVATIVE; GALLOFLAVIN; GEMCITABINE; GLYCOLIC ACID; GOSSYPOL; GOSSYPOL DERIVATIVE; INDOLE DERIVATIVE; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; LACTATE DEHYDROGENASE 5 INHIBITOR; MORIN; N HYDROXYINDOLE DERIVATIVE; NICOTINAMIDE; OXAMIC ACID; OXIDOREDUCTASE INHIBITOR; PACLITAXEL; PYRAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRONE DERIVATIVE; QUINOLINE DERIVATIVE; TRASTUZUMAB; UNCLASSIFIED DRUG; ENZYME INHIBITOR; ISOENZYME;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CANCER CHEMOTHERAPY; CARCINOGENESIS; CELL KILLING; CELL METABOLISM; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHIMERA; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC50; NONHUMAN; OXIDATIVE STRESS; REVIEW; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; DRUG DESIGN; ENZYMOLOGY; NEOPLASM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; ISOENZYMES; L-LACTATE DEHYDROGENASE; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84956637843     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00168     Document Type: Review

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