-
1
-
-
0033919717
-
Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion
-
Ainscow E.K., Zhao C., Rutter G.A. Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion. Diabetes 2000, 49:1149-1155.
-
(2000)
Diabetes
, vol.49
, pp. 1149-1155
-
-
Ainscow, E.K.1
Zhao, C.2
Rutter, G.A.3
-
2
-
-
15244355745
-
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
-
Avalos J.L., Bever K.M., Wolberger C. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol. Cell 2005, 17:855-868.
-
(2005)
Mol. Cell
, vol.17
, pp. 855-868
-
-
Avalos, J.L.1
Bever, K.M.2
Wolberger, C.3
-
3
-
-
77956419439
-
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
-
Bonuccelli G., Tsirigos A., Whitaker-Menezes D., Pavlides S., Pestell R.G., Chiavarina B., Frank P.G., Flomenberg N., Howell A., Martinez-Outschoorn U.E., et al. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010, 9:3506-3514.
-
(2010)
Cell Cycle
, vol.9
, pp. 3506-3514
-
-
Bonuccelli, G.1
Tsirigos, A.2
Whitaker-Menezes, D.3
Pavlides, S.4
Pestell, R.G.5
Chiavarina, B.6
Frank, P.G.7
Flomenberg, N.8
Howell, A.9
Martinez-Outschoorn, U.E.10
-
4
-
-
33744826296
-
Cancer's sweet tooth
-
Bui T., Thompson C.B. Cancer's sweet tooth. Cancer Cell 2006, 9:419-420.
-
(2006)
Cancer Cell
, vol.9
, pp. 419-420
-
-
Bui, T.1
Thompson, C.B.2
-
5
-
-
0024148694
-
Mitochondrial membrane potential in living cells
-
Chen L.B. Mitochondrial membrane potential in living cells. Annu. Rev. Cell Biol. 1988, 4:155-181.
-
(1988)
Annu. Rev. Cell Biol.
, vol.4
, pp. 155-181
-
-
Chen, L.B.1
-
6
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
Olsen, J.V.7
Mann, M.8
-
7
-
-
77949328788
-
Chaperone-mediated autophagy: selectivity pays off
-
Cuervo A.M. Chaperone-mediated autophagy: selectivity pays off. Trends Endocrinol. Metab. 2010, 21:142-150.
-
(2010)
Trends Endocrinol. Metab.
, vol.21
, pp. 142-150
-
-
Cuervo, A.M.1
-
8
-
-
0028848119
-
Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation
-
Cuervo A.M., Knecht E., Terlecky S.R., Dice J.F. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am. J. Physiol. 1995, 269:C1200-C1208.
-
(1995)
Am. J. Physiol.
, vol.269
-
-
Cuervo, A.M.1
Knecht, E.2
Terlecky, S.R.3
Dice, J.F.4
-
9
-
-
0031459979
-
Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres
-
Ekwall K., Olsson T., Turner B.M., Cranston G., Allshire R.C. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. Cell 1997, 91:1021-1032.
-
(1997)
Cell
, vol.91
, pp. 1021-1032
-
-
Ekwall, K.1
Olsson, T.2
Turner, B.M.3
Cranston, G.4
Allshire, R.C.5
-
10
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin V.R., St-Pierre J., Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9:425-434.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
11
-
-
0035793107
-
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
-
Furumai R., Komatsu Y., Nishino N., Khochbin S., Yoshida M., Horinouchi S. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc. Natl. Acad. Sci. USA 2001, 98:87-92.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 87-92
-
-
Furumai, R.1
Komatsu, Y.2
Nishino, N.3
Khochbin, S.4
Yoshida, M.5
Horinouchi, S.6
-
12
-
-
0000384544
-
Lactic Dehydrogenase in Human Neoplastic Tissues
-
Goldman R.D., Kaplan N.O., Hall T.C. Lactic Dehydrogenase in Human Neoplastic Tissues. Cancer Res. 1964, 24:389-399.
-
(1964)
Cancer Res.
, vol.24
, pp. 389-399
-
-
Goldman, R.D.1
Kaplan, N.O.2
Hall, T.C.3
-
13
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
14
-
-
63049132756
-
Acetylation targets mutant huntingtin to autophagosomes for degradation
-
Jeong H., Then F., Melia T.J., Mazzulli J.R., Cui L., Savas J.N., Voisine C., Paganetti P., Tanese N., Hart A.C., et al. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 2009, 137:60-72.
-
(2009)
Cell
, vol.137
, pp. 60-72
-
-
Jeong, H.1
Then, F.2
Melia, T.J.3
Mazzulli, J.R.4
Cui, L.5
Savas, J.N.6
Voisine, C.7
Paganetti, P.8
Tanese, N.9
Hart, A.C.10
-
15
-
-
79959906869
-
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
-
Jiang W., Wang S., Xiao M., Lin Y., Zhou L., Lei Q., Xiong Y., Guan K.L., Zhao S. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol. Cell 2011, 43:33-44.
-
(2011)
Mol. Cell
, vol.43
, pp. 33-44
-
-
Jiang, W.1
Wang, S.2
Xiao, M.3
Lin, Y.4
Zhou, L.5
Lei, Q.6
Xiong, Y.7
Guan, K.L.8
Zhao, S.9
-
16
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 2006, 23:607-618.
-
(2006)
Mol. Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
-
17
-
-
80054769188
-
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
-
Kim H.S., Vassilopoulos A., Wang R.H., Lahusen T., Xiao Z., Xu X., Li C., Veenstra T.D., Li B., Yu H., et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 2011, 20:487-499.
-
(2011)
Cancer Cell
, vol.20
, pp. 487-499
-
-
Kim, H.S.1
Vassilopoulos, A.2
Wang, R.H.3
Lahusen, T.4
Xiao, Z.5
Xu, X.6
Li, C.7
Veenstra, T.D.8
Li, B.9
Yu, H.10
-
18
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol W.H., Bounds P.L., Dang C.V. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 2011, 11:325-337.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
19
-
-
0141730410
-
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
-
Tumour and Angiogenesis Research Group
-
Koukourakis M.I., Giatromanolaki A., Sivridis E., Bougioukas G., Didilis V., Gatter K.C., Harris A.L. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br. J. Cancer 2003, 89:877-885. Tumour and Angiogenesis Research Group.
-
(2003)
Br. J. Cancer
, vol.89
, pp. 877-885
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Bougioukas, G.4
Didilis, V.5
Gatter, K.C.6
Harris, A.L.7
-
20
-
-
33749027749
-
Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway-a report of the Tumour Angiogenesis Research Group
-
Tumour Angiogenesis Research Group
-
Koukourakis M.I., Giatromanolaki A., Sivridis E., Gatter K.C., Harris A.L. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway-a report of the Tumour Angiogenesis Research Group. J. Clin. Oncol. 2006, 24:4301-4308. Tumour Angiogenesis Research Group.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4301-4308
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Gatter, K.C.4
Harris, A.L.5
-
21
-
-
57649086035
-
Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases
-
Koukourakis M.I., Kontomanolis E., Giatromanolaki A., Sivridis E., Liberis V. Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases. Gynecol. Obstet. Invest. 2009, 67:162-168.
-
(2009)
Gynecol. Obstet. Invest.
, vol.67
, pp. 162-168
-
-
Koukourakis, M.I.1
Kontomanolis, E.2
Giatromanolaki, A.3
Sivridis, E.4
Liberis, V.5
-
22
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A., Cooper C.R., Gouw A.M., Dinavahi R., Maitra A., Deck L.M., Royer R.E., Vander Jagt D.L., Semenza G.L., Dang C.V. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc. Natl. Acad. Sci. USA 2010, 107:2037-2042.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
Royer, R.E.7
Vander Jagt, D.L.8
Semenza, G.L.9
Dang, C.V.10
-
23
-
-
33646342738
-
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss
-
Lei Q., Jiao J., Xin L., Chang C.J., Wang S., Gao J., Gleave M.E., Witte O.N., Liu X., Wu H. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell 2006, 9:367-378.
-
(2006)
Cancer Cell
, vol.9
, pp. 367-378
-
-
Lei, Q.1
Jiao, J.2
Xin, L.3
Chang, C.J.4
Wang, S.5
Gao, J.6
Gleave, M.E.7
Witte, O.N.8
Liu, X.9
Wu, H.10
-
24
-
-
0030794277
-
Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene
-
Lewis B.C., Shim H., Li Q., Wu C.S., Lee L.A., Maity A., Dang C.V. Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Mol. Cell. Biol. 1997, 17:4967-4978.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4967-4978
-
-
Lewis, B.C.1
Shim, H.2
Li, Q.3
Wu, C.S.4
Lee, L.A.5
Maity, A.6
Dang, C.V.7
-
25
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
26
-
-
40949099577
-
Genetically encoding N(epsilon)-acetyllysine in recombinant proteins
-
Neumann H., Peak-Chew S.Y., Chin J.W. Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. Nat. Chem. Biol. 2008, 4:232-234.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 232-234
-
-
Neumann, H.1
Peak-Chew, S.Y.2
Chin, J.W.3
-
27
-
-
70349765673
-
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation
-
Neumann H., Hancock S.M., Buning R., Routh A., Chapman L., Somers J., Owen-Hughes T., van Noort J., Rhodes D., Chin J.W. A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol. Cell 2009, 36:153-163.
-
(2009)
Mol. Cell
, vol.36
, pp. 153-163
-
-
Neumann, H.1
Hancock, S.M.2
Buning, R.3
Routh, A.4
Chapman, L.5
Somers, J.6
Owen-Hughes, T.7
van Noort, J.8
Rhodes, D.9
Chin, J.W.10
-
28
-
-
0035342452
-
Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase
-
Read J.A., Winter V.J., Eszes C.M., Sessions R.B., Brady R.L. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins 2001, 43:175-185.
-
(2001)
Proteins
, vol.43
, pp. 175-185
-
-
Read, J.A.1
Winter, V.J.2
Eszes, C.M.3
Sessions, R.B.4
Brady, R.L.5
-
29
-
-
78650533229
-
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
-
Ross J.M., Öberg J., Brené S., Coppotelli G., Terzioglu M., Pernold K., Goiny M., Sitnikov R., Kehr J., Trifunovic A., et al. High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proc. Natl. Acad. Sci. USA 2010, 107:20087-20092.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 20087-20092
-
-
Ross, J.M.1
Öberg, J.2
Brené, S.3
Coppotelli, G.4
Terzioglu, M.5
Pernold, K.6
Goiny, M.7
Sitnikov, R.8
Kehr, J.9
Trifunovic, A.10
-
30
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza G.L., Jiang B.H., Leung S.W., Passantino R., Concordet J.P., Maire P., Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 1996, 271:32529-32537.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
Giallongo, A.7
-
31
-
-
0030921103
-
C-Myc transactivation of LDH-A: implications for tumor metabolism and growth
-
Shim H., Dolde C., Lewis B.C., Wu C.S., Dang G., Jungmann R.A., Dalla-Favera R., Dang C.V. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. USA 1997, 94:6658-6663.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
Dalla-Favera, R.7
Dang, C.V.8
-
32
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
33
-
-
79953329777
-
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis
-
Végran F., Boidot R., Michiels C., Sonveaux P., Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 2011, 71:2550-2560.
-
(2011)
Cancer Res.
, vol.71
, pp. 2550-2560
-
-
Végran, F.1
Boidot, R.2
Michiels, C.3
Sonveaux, P.4
Feron, O.5
-
34
-
-
77149120797
-
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux
-
Wang Q., Zhang Y., Yang C., Xiong H., Lin Y., Yao J., Li H., Xie L., Zhao W., Yao Y., et al. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 2010, 327:1004-1007.
-
(2010)
Science
, vol.327
, pp. 1004-1007
-
-
Wang, Q.1
Zhang, Y.2
Yang, C.3
Xiong, H.4
Lin, Y.5
Yao, J.6
Li, H.7
Xie, L.8
Zhao, W.9
Yao, Y.10
-
35
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
36
-
-
0025801067
-
Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats
-
Wing S.S., Chiang H.L., Goldberg A.L., Dice J.F. Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats. Biochem. J. 1991, 275:165-169.
-
(1991)
Biochem. J.
, vol.275
, pp. 165-169
-
-
Wing, S.S.1
Chiang, H.L.2
Goldberg, A.L.3
Dice, J.F.4
-
37
-
-
66449103009
-
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
-
Xie H., Valera V.A., Merino M.J., Amato A.M., Signoretti S., Linehan W.M., Sukhatme V.P., Seth P. LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol. Cancer Ther. 2009, 8:626-635.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 626-635
-
-
Xie, H.1
Valera, V.A.2
Merino, M.J.3
Amato, A.M.4
Signoretti, S.5
Linehan, W.M.6
Sukhatme, V.P.7
Seth, P.8
-
38
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., Yao J., Zhou L., Zeng Y., Li H., et al. Regulation of cellular metabolism by protein lysine acetylation. Science 2010, 327:1000-1004.
-
(2010)
Science
, vol.327
, pp. 1000-1004
-
-
Zhao, S.1
Xu, W.2
Jiang, W.3
Yu, W.4
Lin, Y.5
Zhang, T.6
Yao, J.7
Zhou, L.8
Zeng, Y.9
Li, H.10
|