Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase

FEBS Letters

Volumn 584, Issue 1, 2010, Pages 159-165

  Kotlyar, Alexander B ^a,b,c   Randazzo, Antonio ^d   Honbo, Norman ^b   Jin, Zhu Qui ^b   Karliner, Joel S ^b   Cecchini, Gary ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cardioprotection; Competitive inhibition; Enzyme kinetics; Lactate dehydrogenase; NADH derivative

Indexed keywords

ADENOSINE DERIVATIVE; GLYCOLIC ACID; LACTATE DEHYDROGENASE INHIBITOR; NICOTINAMIDE; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CELL PROTECTION; CELL STRESS; CHEMICAL REACTION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IN VITRO STUDY; INCUBATION TIME; ISOLATED HEART; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION INJURY;

ANIMALS; CARDIOTONIC AGENTS; ENZYME INHIBITORS; L-LACTATE DEHYDROGENASE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NAD;

EID: 71549128014     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.11.022     Document Type: Article

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