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Volumn 126, Issue 1, 2016, Pages 23-31

Sepsis-induced immune dysfunction: Can immune therapies reduce mortality?

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; DISEASE ASSOCIATION; HUMAN; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INNATE IMMUNITY; INTENSIVE CARE; INTERVENTION STUDY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPSIS INDUCED IMMUNE DYSFUNCTION; ANIMAL; BONE MARROW CELL; DENDRITIC CELL; IMMUNOLOGY; LYMPHOCYTE; MACROPHAGE; MONOCYTE; NEUTROPHIL;

EID: 84956616365     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI82224     Document Type: Review
Times cited : (495)

References (126)
  • 1
    • 84928485055 scopus 로고    scopus 로고
    • Systemic inflammatory response syndrome criteria in defining severe sepsis
    • Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015;372(17):1629-1638.
    • (2015) N Engl J Med. , vol.372 , Issue.17 , pp. 1629-1638
    • Kaukonen, K.M.1    Bailey, M.2    Pilcher, D.3    Cooper, D.J.4    Bellomo, R.5
  • 2
    • 0026874127 scopus 로고
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • [No authors listed]. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20(6):864-874.
    • (1992) Crit Care Med. , vol.20 , Issue.6 , pp. 864-874
  • 3
    • 84891652126 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis
    • Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence. 2014;5(1):4-11.
    • (2014) Virulence. , vol.5 , Issue.1 , pp. 4-11
    • Mayr, F.B.1    Yende, S.2    Angus, D.C.3
  • 4
    • 84858761997 scopus 로고    scopus 로고
    • A comparison of critical care research funding and the financial burden of critical illness in the United States
    • Coopersmith CM, et al. A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med. 2012;40(4):1072-1079.
    • (2012) Crit Care Med. , vol.40 , Issue.4 , pp. 1072-1079
    • Coopersmith, C.M.1
  • 5
    • 29744447480 scopus 로고    scopus 로고
    • The effect of age on the development and outcome of adult sepsis
    • Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006;34(1):15-21.
    • (2006) Crit Care Med. , vol.34 , Issue.1 , pp. 15-21
    • Martin, G.S.1    Mannino, D.M.2    Moss, M.3
  • 6
    • 84925361902 scopus 로고    scopus 로고
    • The epidemiology of chronic critical illness in the United States
    • Kahn JM, et al. The epidemiology of chronic critical illness in the United States. Crit Care Med. 2015;43(2):282-287.
    • (2015) Crit Care Med. , vol.43 , Issue.2 , pp. 282-287
    • Kahn, J.M.1
  • 7
    • 84876665421 scopus 로고    scopus 로고
    • Benchmarking the incidence and mortality of severe sepsis in the United States
    • Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013;41(5):1167-1174.
    • (2013) Crit Care Med. , vol.41 , Issue.5 , pp. 1167-1174
    • Gaieski, D.F.1    Edwards, J.M.2    Kallan, M.J.3    Carr, B.G.4
  • 8
    • 84898684570 scopus 로고    scopus 로고
    • Sepsis: Current dogma and new perspectives
    • Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity. 2014;40(4):463-475.
    • (2014) Immunity. , vol.40 , Issue.4 , pp. 463-475
    • Deutschman, C.S.1    Tracey, K.J.2
  • 9
    • 84862669323 scopus 로고    scopus 로고
    • A historical perspective on sepsis
    • Ward PA, Bosmann M. A historical perspective on sepsis. Am J Pathol. 2012;181(1):2-7.
    • (2012) Am J Pathol. , vol.181 , Issue.1 , pp. 2-7
    • Ward, P.A.1    Bosmann, M.2
  • 10
    • 0023491364 scopus 로고
    • Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
    • Tracey KJ, et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 1987;330(6149):662-664.
    • (1987) Nature. , vol.330 , Issue.6149 , pp. 662-664
    • Tracey, K.J.1
  • 11
    • 84897065166 scopus 로고    scopus 로고
    • The Surviving Sepsis Campaign: Past, present and future
    • Schorr CA, Dellinger RP. The Surviving Sepsis Campaign: past, present and future. Trends Mol Med. 2014;20(4):192-194.
    • (2014) Trends Mol Med. , vol.20 , Issue.4 , pp. 192-194
    • Schorr, C.A.1    Dellinger, R.P.2
  • 12
    • 84255194001 scopus 로고    scopus 로고
    • Immunosuppression in patients who die of sepsis and multiple organ failure
    • Boomer JS, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011;306(23):2594-2605.
    • (2011) JAMA. , vol.306 , Issue.23 , pp. 2594-2605
    • Boomer, J.S.1
  • 13
    • 84864545901 scopus 로고    scopus 로고
    • Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care
    • Gentile LF, et al. Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg. 2012;72(6):1491-1501.
    • (2012) J Trauma Acute Care Surg. , vol.72 , Issue.6 , pp. 1491-1501
    • Gentile, L.F.1
  • 15
    • 0028952314 scopus 로고
    • Evolving concepts in the pathogenesis of postinjury multiple organ failure
    • Moore FA, Moore EE. Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am. 1995;75(2):257-277.
    • (1995) Surg Clin North Am. , vol.75 , Issue.2 , pp. 257-277
    • Moore, F.A.1    Moore, E.E.2
  • 16
    • 84856135298 scopus 로고    scopus 로고
    • Improving long-term outcomes after discharge from intensive care unit: Report from a stakeholders' conference
    • Needham DM, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012;40(2):502-509.
    • (2012) Crit Care Med. , vol.40 , Issue.2 , pp. 502-509
    • Needham, D.M.1
  • 17
    • 44449160935 scopus 로고    scopus 로고
    • Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    • Yende S, et al. Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med. 2008;177(11):1242-1247.
    • (2008) Am J Respir Crit Care Med. , vol.177 , Issue.11 , pp. 1242-1247
    • Yende, S.1
  • 18
    • 84922549250 scopus 로고    scopus 로고
    • Exploring the scope of post-intensive care syndrome therapy and care: Engagement of non-critical care providers and survivors in a second stakeholders meeting
    • Elliott D, et al. Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med. 2014;42(12):2518-2526.
    • (2014) Crit Care Med. , vol.42 , Issue.12 , pp. 2518-2526
    • Elliott, D.1
  • 19
    • 84904549329 scopus 로고    scopus 로고
    • Parallels between cancer and infectious disease
    • Hotchkiss RS, Moldawer LL. Parallels between cancer and infectious disease. N Engl J Med. 2014;371(4):380-383.
    • (2014) N Engl J Med. , vol.371 , Issue.4 , pp. 380-383
    • Hotchkiss, R.S.1    Moldawer, L.L.2
  • 20
    • 84888325490 scopus 로고    scopus 로고
    • Sepsisinduced immunosuppression: From cellular dysfunctions to immunotherapy
    • Hotchkiss RS, Monneret G, Payen D. Sepsisinduced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862-874.
    • (2013) Nat Rev Immunol. , vol.13 , Issue.12 , pp. 862-874
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 21
    • 67650477632 scopus 로고    scopus 로고
    • Magic bullets and surrogate biomarkers circa 2009
    • Delano MJ, Moldawer LL. Magic bullets and surrogate biomarkers circa 2009. Crit Care Med. 2009;37(5):1796-1798.
    • (2009) Crit Care Med. , vol.37 , Issue.5 , pp. 1796-1798
    • Delano, M.J.1    Moldawer, L.L.2
  • 22
    • 84875262757 scopus 로고    scopus 로고
    • The inflammatory response in sepsis
    • Bosmann M, Ward PA. The inflammatory response in sepsis. Trends Immunol. 2013;34(3):129-136.
    • (2013) Trends Immunol. , vol.34 , Issue.3 , pp. 129-136
    • Bosmann, M.1    Ward, P.A.2
  • 24
    • 0030843156 scopus 로고    scopus 로고
    • Sepsis: A new hypothesis for pathogenesis of the disease process
    • Bone RC, Grodzin CJ, Balk RA. Sepsis: A new hypothesis for pathogenesis of the disease process. Chest. 1997;112(1):235-243.
    • (1997) Chest. , vol.112 , Issue.1 , pp. 235-243
    • Bone, R.C.1    Grodzin, C.J.2    Balk, R.A.3
  • 26
    • 84862908403 scopus 로고    scopus 로고
    • A genomic storm in critically injured humans
    • Xiao W, et al. A genomic storm in critically injured humans. J Exp Med. 2011;208(13):2581-2590.
    • (2011) J Exp Med. , vol.208 , Issue.13 , pp. 2581-2590
    • Xiao, W.1
  • 27
    • 84876666943 scopus 로고    scopus 로고
    • Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients
    • Cuenca AG, et al. Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med. 2013;41(5):1175-1185.
    • (2013) Crit Care Med. , vol.41 , Issue.5 , pp. 1175-1185
    • Cuenca, A.G.1
  • 28
    • 84897378109 scopus 로고    scopus 로고
    • The new normal: Immunomodulatory agents against sepsis immune suppression
    • Hutchins NA, Unsinger J, Hotchkiss RS, Ayala A. The new normal: immunomodulatory agents against sepsis immune suppression. Trends Mol Med. 2014;20(4):224-233.
    • (2014) Trends Mol Med. , vol.20 , Issue.4 , pp. 224-233
    • Hutchins, N.A.1    Unsinger, J.2    Hotchkiss, R.S.3    Ayala, A.4
  • 29
    • 84901494412 scopus 로고    scopus 로고
    • A better understanding of why murine models of trauma do not recapitulate the human syndrome
    • Gentile LF, et al. A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med. 2014;42(6):1406-1413.
    • (2014) Crit Care Med. , vol.42 , Issue.6 , pp. 1406-1413
    • Gentile, L.F.1
  • 30
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006;6(3):173-182.
    • (2006) Nat Rev Immunol. , vol.6 , Issue.3 , pp. 173-182
    • Nathan, C.1
  • 31
    • 23844481358 scopus 로고    scopus 로고
    • Neutrophil homeostasis: A new role for stromal cell-derived factor-1
    • Link DC. Neutrophil homeostasis: A new role for stromal cell-derived factor-1. Immunol Res. 2005;32(1-3):169-178.
    • (2005) Immunol Res. , vol.32 , Issue.1-3 , pp. 169-178
    • Link, D.C.1
  • 32
    • 33750288937 scopus 로고    scopus 로고
    • Apoptosis and caspases regulate death and inflammation in sepsis
    • Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol. 2006;6(11):813-822.
    • (2006) Nat Rev Immunol. , vol.6 , Issue.11 , pp. 813-822
    • Hotchkiss, R.S.1    Nicholson, D.W.2
  • 33
    • 79251537742 scopus 로고    scopus 로고
    • Sepsis induces early alterations in innate immunity that impact mortality to secondary infection
    • Delano MJ, et al. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol. 2011;186(1):195-202.
    • (2011) J Immunol. , vol.186 , Issue.1 , pp. 195-202
    • Delano, M.J.1
  • 34
    • 77954974268 scopus 로고    scopus 로고
    • CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    • Eash KJ, Greenbaum AM, Gopalan PK, Link DC. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest. 2010;120(7):2423-2431.
    • (2010) J Clin Invest. , vol.120 , Issue.7 , pp. 2423-2431
    • Eash, K.J.1    Greenbaum, A.M.2    Gopalan, P.K.3    Link, D.C.4
  • 35
    • 79960532406 scopus 로고    scopus 로고
    • Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling
    • Delano MJ, et al. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol. 2011;187(2):911-918.
    • (2011) J Immunol. , vol.187 , Issue.2 , pp. 911-918
    • Delano, M.J.1
  • 36
    • 84906939114 scopus 로고    scopus 로고
    • Persistent neutrophil dysfunction and suppression of acute lung injury in mice following cecal ligation and puncture sepsis
    • Grailer JJ, Kalbitz M, Zetoune FS, Ward PA. Persistent neutrophil dysfunction and suppression of acute lung injury in mice following cecal ligation and puncture sepsis. J Innate Immun. 2014;6(5):695-705.
    • (2014) J Innate Immun. , vol.6 , Issue.5 , pp. 695-705
    • Grailer, J.J.1    Kalbitz, M.2    Zetoune, F.S.3    Ward, P.A.4
  • 37
    • 84916202796 scopus 로고    scopus 로고
    • Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin alpha3beta1-dependent
    • Lerman YV, et al. Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin alpha3beta1-dependent. Blood. 2014;124(24):3515-3523.
    • (2014) Blood. , vol.124 , Issue.24 , pp. 3515-3523
    • Lerman, Y.V.1
  • 38
    • 62649121369 scopus 로고    scopus 로고
    • Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
    • Alves-Filho JC, et al. Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc Natl Acad Sci U S A. 2009;106(10):4018-4023.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.10 , pp. 4018-4023
    • Alves-Filho, J.C.1
  • 39
    • 84892758634 scopus 로고    scopus 로고
    • Aged mice are unable to mount an effective myeloid response to sepsis
    • Nacionales DC, et al. Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol. 2014;192(2):612-622.
    • (2014) J Immunol. , vol.192 , Issue.2 , pp. 612-622
    • Nacionales, D.C.1
  • 40
    • 34250359119 scopus 로고    scopus 로고
    • MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    • Delano MJ, et al. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med. 2007;204(6):1463-1474.
    • (2007) J Exp Med. , vol.204 , Issue.6 , pp. 1463-1474
    • Delano, M.J.1
  • 41
    • 84907202610 scopus 로고    scopus 로고
    • Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells
    • Davey MS, et al. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. J Immunol. 2014;193(7):3704-3716.
    • (2014) J Immunol. , vol.193 , Issue.7 , pp. 3704-3716
    • Davey, M.S.1
  • 42
    • 79955966974 scopus 로고    scopus 로고
    • C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients
    • Morris AC, et al. C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients. Blood. 2011;117(19):5178-5188.
    • (2011) Blood. , vol.117 , Issue.19 , pp. 5178-5188
    • Morris, A.C.1
  • 43
    • 84870607793 scopus 로고    scopus 로고
    • Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung
    • Wilkinson TS, et al. Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung. Chest. 2012;142(6):1425-1432.
    • (2012) Chest. , vol.142 , Issue.6 , pp. 1425-1432
    • Wilkinson, T.S.1
  • 44
    • 0024600505 scopus 로고
    • Comparison of trauma assessment scores and their use in prediction of infection and death
    • Cheadle WG, Wilson M, Hershman MJ, Bergamini D, Richardson JD, Polk HC Jr. Comparison of trauma assessment scores and their use in prediction of infection and death. Ann Surg. 1989;209(5):541-545.
    • (1989) Ann Surg. , vol.209 , Issue.5 , pp. 541-545
    • Cheadle, W.G.1    Wilson, M.2    Hershman, M.J.3    Bergamini, D.4    Richardson, J.D.5    Polk, H.C.6
  • 45
    • 0023769976 scopus 로고
    • Depressed interferon gamma production and monocyte HLA-DR expression after severe injury
    • Livingston DH, Appel SH, Wellhausen SR, Sonnenfeld G, Polk HC Jr. Depressed interferon gamma production and monocyte HLA-DR expression after severe injury. Arch Surg. 1988;123(11):1309-1312.
    • (1988) Arch Surg. , vol.123 , Issue.11 , pp. 1309-1312
    • Livingston, D.H.1    Appel, S.H.2    Wellhausen, S.R.3    Sonnenfeld, G.4    Polk, H.C.5
  • 47
    • 0030917203 scopus 로고    scopus 로고
    • Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
    • Docke WD, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med. 1997;3(6):678-681.
    • (1997) Nat Med. , vol.3 , Issue.6 , pp. 678-681
    • Docke, W.D.1
  • 48
    • 84891639053 scopus 로고    scopus 로고
    • Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock
    • Cazalis MA, et al. Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock. Crit Care. 2013;17(6):R287.
    • (2013) Crit Care. , vol.17 , Issue.6 , pp. R287
    • Cazalis, M.A.1
  • 49
    • 78349287748 scopus 로고    scopus 로고
    • Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma
    • Cheron A, et al. Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma. Crit Care. 2010;14(6):R208.
    • (2010) Crit Care. , vol.14 , Issue.6 , pp. R208
    • Cheron, A.1
  • 50
    • 78650419440 scopus 로고    scopus 로고
    • Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock
    • Landelle C, et al. Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med. 2010;36(11):1859-1866.
    • (2010) Intensive Care Med. , vol.36 , Issue.11 , pp. 1859-1866
    • Landelle, C.1
  • 51
    • 33750306678 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharideinduced monocyte survival through a Fas/ Fas ligand-dependent mechanism
    • Venet F, et al. Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharideinduced monocyte survival through a Fas/ Fas ligand-dependent mechanism. J Immunol. 2006;177(9):6540-6547.
    • (2006) J Immunol. , vol.177 , Issue.9 , pp. 6540-6547
    • Venet, F.1
  • 52
    • 40349091729 scopus 로고    scopus 로고
    • Monitoring immune dysfunctions in the septic patient: A new skin for the old ceremony
    • Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: A new skin for the old ceremony. Mol Med. 2008;14(1-2):64-78.
    • (2008) Mol Med. , vol.14 , Issue.1-2 , pp. 64-78
    • Monneret, G.1    Venet, F.2    Pachot, A.3    Lepape, A.4
  • 53
    • 79952378225 scopus 로고    scopus 로고
    • Epigenetic regulation of immune cell functions during post-septic immunosuppression
    • Carson WF, Cavassani KA, Dou Y, Kunkel SL. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics. 2011;6(3):273-283.
    • (2011) Epigenetics. , vol.6 , Issue.3 , pp. 273-283
    • Carson, W.F.1    Cavassani, K.A.2    Dou, Y.3    Kunkel, S.L.4
  • 54
    • 70350435962 scopus 로고    scopus 로고
    • Epigenetic regulation of the alternatively activated macrophage phenotype
    • Ishii M, et al. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood. 2009;114(15):3244-3254.
    • (2009) Blood. , vol.114 , Issue.15 , pp. 3244-3254
    • Ishii, M.1
  • 55
    • 84907483941 scopus 로고    scopus 로고
    • Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
    • Saeed S, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 2014;345(6204):1251086.
    • (2014) Science. , vol.345 , Issue.6204 , pp. 1251086
    • Saeed, S.1
  • 57
    • 84885677676 scopus 로고    scopus 로고
    • Reduced frequency of CD56 dim CD16 pos natural killer cells in pediatric systemic inflammatory response syndrome/sepsis patients
    • Halstead ES, Carcillo JA, Schilling B, Greiner RJ, Whiteside TL. Reduced frequency of CD56 dim CD16 pos natural killer cells in pediatric systemic inflammatory response syndrome/sepsis patients. Pediatr Res. 2013;74(4):427-432.
    • (2013) Pediatr Res. , vol.74 , Issue.4 , pp. 427-432
    • Halstead, E.S.1    Carcillo, J.A.2    Schilling, B.3    Greiner, R.J.4    Whiteside, T.L.5
  • 58
    • 34447623218 scopus 로고    scopus 로고
    • Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis
    • Giamarellos-Bourboulis EJ, et al. Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis. Crit Care. 2006;10(6):R166.
    • (2006) Crit Care. , vol.10 , Issue.6 , pp. R166
    • Giamarellos-Bourboulis, E.J.1
  • 60
    • 84870250994 scopus 로고    scopus 로고
    • Interferon-gamma production by natural killer cells and cytomegalovirus in critically ill patients
    • Chiche L, et al. Interferon-gamma production by natural killer cells and cytomegalovirus in critically ill patients. Crit Care Med. 2012;40(12):3162-3169.
    • (2012) Crit Care Med. , vol.40 , Issue.12 , pp. 3162-3169
    • Chiche, L.1
  • 61
    • 47849130092 scopus 로고    scopus 로고
    • Cytomegalovirus reactivation in critically ill immunocompetent patients
    • Limaye AP, et al. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA. 2008;300(4):413-422.
    • (2008) JAMA. , vol.300 , Issue.4 , pp. 413-422
    • Limaye, A.P.1
  • 62
    • 0036499162 scopus 로고    scopus 로고
    • Depletion of dendritic cells, but not macrophages, in patients with sepsis
    • Hotchkiss RS, et al. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol. 2002;168(5):2493-2500.
    • (2002) J Immunol. , vol.168 , Issue.5 , pp. 2493-2500
    • Hotchkiss, R.S.1
  • 63
    • 80054770000 scopus 로고    scopus 로고
    • Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock
    • Grimaldi D, et al. Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock. Intensive Care Med. 2011;37(9):1438-1446.
    • (2011) Intensive Care Med. , vol.37 , Issue.9 , pp. 1438-1446
    • Grimaldi, D.1
  • 64
    • 79251552541 scopus 로고    scopus 로고
    • Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis
    • Pastille E, et al. Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis. J Immunol. 2011;186(2):977-986.
    • (2011) J Immunol. , vol.186 , Issue.2 , pp. 977-986
    • Pastille, E.1
  • 65
    • 4344711657 scopus 로고    scopus 로고
    • Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis
    • Efron PA, et al. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol. 2004;173(5):3035-3043.
    • (2004) J Immunol. , vol.173 , Issue.5 , pp. 3035-3043
    • Efron, P.A.1
  • 66
    • 23844498727 scopus 로고    scopus 로고
    • CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis
    • Scumpia PO, et al. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol. 2005;175(5):3282-3286.
    • (2005) J Immunol. , vol.175 , Issue.5 , pp. 3282-3286
    • Scumpia, P.O.1
  • 67
    • 0038781981 scopus 로고    scopus 로고
    • Stimulation of hematopoiesis by the Fms-like tyrosine kinase 3 ligand restores bacterial induction of Th1 cytokines in thermally injured mice
    • Toliver-Kinsky TE, Lin CY, Herndon DN, Sherwood ER. Stimulation of hematopoiesis by the Fms-like tyrosine kinase 3 ligand restores bacterial induction of Th1 cytokines in thermally injured mice. Infect Immun. 2003;71(6):3058-3067.
    • (2003) Infect Immun. , vol.71 , Issue.6 , pp. 3058-3067
    • Toliver-Kinsky, T.E.1    Lin, C.Y.2    Herndon, D.N.3    Sherwood, E.R.4
  • 68
    • 18244376372 scopus 로고    scopus 로고
    • Reversal of long-term sepsisinduced immunosuppression by dendritic cells
    • Benjamim CF, Lundy SK, Lukacs NW, Hogaboam CM, Kunkel SL. Reversal of long-term sepsisinduced immunosuppression by dendritic cells. Blood. 2005;105(9):3588-3595.
    • (2005) Blood. , vol.105 , Issue.9 , pp. 3588-3595
    • Benjamim, C.F.1    Lundy, S.K.2    Lukacs, N.W.3    Hogaboam, C.M.4    Kunkel, S.L.5
  • 69
    • 0035118324 scopus 로고    scopus 로고
    • Arginase i expression and activity in human mononuclear cells after injury
    • Ochoa JB, et al. Arginase I expression and activity in human mononuclear cells after injury. Ann Surg. 2001;233(3):393-399.
    • (2001) Ann Surg. , vol.233 , Issue.3 , pp. 393-399
    • Ochoa, J.B.1
  • 71
    • 79952822608 scopus 로고    scopus 로고
    • A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma
    • Cuenca AG, et al. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med. 2011;17(3-4):281-292.
    • (2011) Mol Med. , vol.17 , Issue.3-4 , pp. 281-292
    • Cuenca, A.G.1
  • 72
    • 32044439372 scopus 로고    scopus 로고
    • CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
    • Makarenkova VP, Bansal V, Matta BM, Perez LA, Ochoa JB. CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol. 2006;176(4):2085-2094.
    • (2006) J Immunol. , vol.176 , Issue.4 , pp. 2085-2094
    • Makarenkova, V.P.1    Bansal, V.2    Matta, B.M.3    Perez, L.A.4    Ochoa, J.B.5
  • 73
    • 77149144182 scopus 로고    scopus 로고
    • Type i interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
    • Kelly-Scumpia KM, et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010;207(2):319-326.
    • (2010) J Exp Med. , vol.207 , Issue.2 , pp. 319-326
    • Kelly-Scumpia, K.M.1
  • 74
    • 77951926024 scopus 로고    scopus 로고
    • Cutting edge: Bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling
    • Scumpia PO, et al. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J Immunol. 2010;184(5):2247-2251.
    • (2010) J Immunol. , vol.184 , Issue.5 , pp. 2247-2251
    • Scumpia, P.O.1
  • 75
    • 0000036329 scopus 로고
    • The kinetics of granulopoiesis in normal man
    • Cartwright GE, Athens JW, Wintrobe MM. The kinetics of granulopoiesis in normal man. Blood. 1964;24:780-803.
    • (1964) Blood. , vol.24 , pp. 780-803
    • Cartwright, G.E.1    Athens, J.W.2    Wintrobe, M.M.3
  • 76
    • 84931576922 scopus 로고    scopus 로고
    • Macrophage-lineage cells negatively regulate the hematopoietic stem cell pool in response to interferon γ at steady state and during infection
    • McCabe A, Zhang Y, Thai V, Jones M, Jordan MB, MacNamara KC. Macrophage-lineage cells negatively regulate the hematopoietic stem cell pool in response to interferon γ at steady state and during infection. Stem Cells. 2015;33(7):2294-2305.
    • (2015) Stem Cells. , vol.33 , Issue.7 , pp. 2294-2305
    • McCabe, A.1    Zhang, Y.2    Thai, V.3    Jones, M.4    Jordan, M.B.5    MacNamara, K.C.6
  • 77
    • 21344461738 scopus 로고    scopus 로고
    • γΔ T cells link innate and adaptive immune responses
    • Holtmeier W, Kabelitz D. γΔ T cells link innate and adaptive immune responses. Chem Immunol Allergy. 2005;86:151-183.
    • (2005) Chem Immunol Allergy. , vol.86 , pp. 151-183
    • Holtmeier, W.1    Kabelitz, D.2
  • 78
    • 84876847107 scopus 로고    scopus 로고
    • Association of gammadelta T cells with disease severity and mortality in septic patients
    • Andreu-Ballester JC, et al. Association of gammadelta T cells with disease severity and mortality in septic patients. Clin Vaccine Immunol. 2013;20(5):738-746.
    • (2013) Clin Vaccine Immunol. , vol.20 , Issue.5 , pp. 738-746
    • Andreu-Ballester, J.C.1
  • 79
    • 84893875610 scopus 로고    scopus 로고
    • Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections
    • Grimaldi D, et al. Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections. Intensive Care Med. 2014;40(2):192-201.
    • (2014) Intensive Care Med. , vol.40 , Issue.2 , pp. 192-201
    • Grimaldi, D.1
  • 80
    • 84875166521 scopus 로고    scopus 로고
    • Intestinal innate immune cells in gut homeostasis and immunosurveillance
    • Tomasello E, Bedoui S. Intestinal innate immune cells in gut homeostasis and immunosurveillance. Immunol Cell Biol. 2013;91(3):201-203.
    • (2013) Immunol Cell Biol. , vol.91 , Issue.3 , pp. 201-203
    • Tomasello, E.1    Bedoui, S.2
  • 81
    • 34248137873 scopus 로고    scopus 로고
    • APC-derived cytokines and T cell polarization in autoimmune inflammation
    • Gutcher I, Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation. J Clin Invest. 2007;117(5):1119-1127.
    • (2007) J Clin Invest. , vol.117 , Issue.5 , pp. 1119-1127
    • Gutcher, I.1    Becher, B.2
  • 82
    • 43349107987 scopus 로고    scopus 로고
    • Regulatory T cell populations in sepsis and trauma
    • Venet F, et al. Regulatory T cell populations in sepsis and trauma. J Leukoc Biol. 2008;83(3):523-535.
    • (2008) J Leukoc Biol. , vol.83 , Issue.3 , pp. 523-535
    • Venet, F.1
  • 83
    • 0035338993 scopus 로고    scopus 로고
    • Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
    • Hotchkiss RS, et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol. 2001;166(11):6952-6963.
    • (2001) J Immunol. , vol.166 , Issue.11 , pp. 6952-6963
    • Hotchkiss, R.S.1
  • 84
    • 0028857787 scopus 로고
    • Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection
    • O'Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, Rodrick ML. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg. 1995;222(4):482-490.
    • (1995) Ann Surg. , vol.222 , Issue.4 , pp. 482-490
    • O'Sullivan, S.T.1    Lederer, J.A.2    Horgan, A.F.3    Chin, D.H.4    Mannick, J.A.5    Rodrick, M.L.6
  • 85
    • 10444265832 scopus 로고    scopus 로고
    • Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock
    • Pachot A, et al. Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clin Immunol. 2005;114(1):61-69.
    • (2005) Clin Immunol. , vol.114 , Issue.1 , pp. 61-69
    • Pachot, A.1
  • 86
    • 79953163170 scopus 로고    scopus 로고
    • Immunity to fungal infections
    • Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11(4):275-288.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.4 , pp. 275-288
    • Romani, L.1
  • 87
    • 84880708586 scopus 로고    scopus 로고
    • Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis
    • Wu HP, Chung K, Lin CY, Jiang BY, Chuang DY, Liu YC. Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis. Inflamm Res. 2013;62(8):751-763.
    • (2013) Inflamm Res. , vol.62 , Issue.8 , pp. 751-763
    • Wu, H.P.1    Chung, K.2    Lin, C.Y.3    Jiang, B.Y.4    Chuang, D.Y.5    Liu, Y.C.6
  • 88
    • 84878700149 scopus 로고    scopus 로고
    • Functional genomics identifies type i interferon pathway as central for host defense against Candida albicans
    • Smeekens SP, et al. Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Nat Commun. 2013;4:1342.
    • (2013) Nat Commun. , vol.4 , pp. 1342
    • Smeekens, S.P.1
  • 89
    • 77951648850 scopus 로고    scopus 로고
    • IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
    • Unsinger J, et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol. 2010;184(7):3768-3779.
    • (2010) J Immunol. , vol.184 , Issue.7 , pp. 3768-3779
    • Unsinger, J.1
  • 90
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • Liston A, Gray DH. Homeostatic control of regulatory T cell diversity. Nat Rev Immunol. 2014;14(3):154-165.
    • (2014) Nat Rev Immunol. , vol.14 , Issue.3 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 91
    • 62949142070 scopus 로고    scopus 로고
    • Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients
    • Venet F, et al. Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med. 2009;35(4):678-686.
    • (2009) Intensive Care Med. , vol.35 , Issue.4 , pp. 678-686
    • Venet, F.1
  • 92
    • 33745817772 scopus 로고    scopus 로고
    • Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling
    • Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest. 2006;116(7):2022-2032.
    • (2006) J Clin Invest. , vol.116 , Issue.7 , pp. 2022-2032
    • Zanin-Zhorov, A.1    Cahalon, L.2    Tal, G.3    Margalit, R.4    Lider, O.5    Cohen, I.R.6
  • 93
    • 33751576739 scopus 로고    scopus 로고
    • Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis
    • Scumpia PO, et al. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol. 2006;177(11):7943-7949.
    • (2006) J Immunol. , vol.177 , Issue.11 , pp. 7943-7949
    • Scumpia, P.O.1
  • 94
    • 36348964853 scopus 로고    scopus 로고
    • Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis
    • Scumpia PO, et al. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007;110(10):3673-3681.
    • (2007) Blood. , vol.110 , Issue.10 , pp. 3673-3681
    • Scumpia, P.O.1
  • 95
    • 77953939271 scopus 로고    scopus 로고
    • The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth
    • Cavassani KA, et al. The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth. Blood. 2010;115(22):4403-4411.
    • (2010) Blood. , vol.115 , Issue.22 , pp. 4403-4411
    • Cavassani, K.A.1
  • 96
    • 84859385739 scopus 로고    scopus 로고
    • Immune regulatory function of B cells
    • Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol. 2012;30:221-241.
    • (2012) Annu Rev Immunol. , vol.30 , pp. 221-241
    • Mauri, C.1    Bosma, A.2
  • 97
    • 84878243507 scopus 로고    scopus 로고
    • Early alterations of B cells in patients with septic shock
    • Monserrat J, et al. Early alterations of B cells in patients with septic shock. Crit Care. 2013;17(3):R105.
    • (2013) Crit Care. , vol.17 , Issue.3 , pp. R105
    • Monserrat, J.1
  • 98
    • 79960751800 scopus 로고    scopus 로고
    • B cells enhance early innate immune responses during bacterial sepsis
    • Kelly-Scumpia KM, et al. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med. 2011;208(8):1673-1682.
    • (2011) J Exp Med. , vol.208 , Issue.8 , pp. 1673-1682
    • Kelly-Scumpia, K.M.1
  • 99
    • 84856655455 scopus 로고    scopus 로고
    • Innate response activator B cells protect against microbial sepsis
    • Rauch PJ, et al. Innate response activator B cells protect against microbial sepsis. Science. 2012;335(6068):597-601.
    • (2012) Science. , vol.335 , Issue.6068 , pp. 597-601
    • Rauch, P.J.1
  • 100
    • 84924787263 scopus 로고    scopus 로고
    • Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis
    • Weber GF, et al. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015;347(6227):1260-1265.
    • (2015) Science. , vol.347 , Issue.6227 , pp. 1260-1265
    • Weber, G.F.1
  • 102
    • 0028000668 scopus 로고
    • Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
    • Lieschke GJ, et al. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood. 1994;84(6):1737-1746.
    • (1994) Blood. , vol.84 , Issue.6 , pp. 1737-1746
    • Lieschke, G.J.1
  • 103
    • 0036302147 scopus 로고    scopus 로고
    • G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    • Petit I, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3(7):687-694.
    • (2002) Nat Immunol. , vol.3 , Issue.7 , pp. 687-694
    • Petit, I.1
  • 104
    • 17344363557 scopus 로고    scopus 로고
    • A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia
    • Nelson S, et al. A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. J Infect Dis. 1998;178(4):1075-1080.
    • (1998) J Infect Dis. , vol.178 , Issue.4 , pp. 1075-1080
    • Nelson, S.1
  • 105
    • 0037323852 scopus 로고    scopus 로고
    • Multicenter, double-blind, placebocontrolled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis
    • Root RK, et al. Multicenter, double-blind, placebocontrolled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit Care Med. 2003;31(2):367-373.
    • (2003) Crit Care Med. , vol.31 , Issue.2 , pp. 367-373
    • Root, R.K.1
  • 106
    • 84887771214 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor: Not just another haematopoietic growth factor
    • Francisco-Cruz A, et al. Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor. Med Oncol. 2014;31(1):774.
    • (2014) Med Oncol. , vol.31 , Issue.1 , pp. 774
    • Francisco-Cruz, A.1
  • 107
    • 84055173351 scopus 로고    scopus 로고
    • A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury
    • Paine R. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med. 2012;40(1):90-97.
    • (2012) Crit Care Med. , vol.40 , Issue.1 , pp. 90-97
    • Paine, R.1
  • 108
    • 70349469854 scopus 로고    scopus 로고
    • Granulocyte-macrophage colonystimulating factor to reverse sepsis-associated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial
    • Meisel C, et al. Granulocyte-macrophage colonystimulating factor to reverse sepsis-associated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med. 2009;180(7):640-648.
    • (2009) Am J Respir Crit Care Med. , vol.180 , Issue.7 , pp. 640-648
    • Meisel, C.1
  • 109
    • 79953819133 scopus 로고    scopus 로고
    • Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome
    • Hall MW, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med. 2011;37(3):525-532.
    • (2011) Intensive Care Med. , vol.37 , Issue.3 , pp. 525-532
    • Hall, M.W.1
  • 110
    • 79751531129 scopus 로고    scopus 로고
    • Granulocytecolony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: A meta-analysis
    • Bo L, Wang F, Zhu J, Li J, Deng X. Granulocytecolony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: A meta-analysis. Crit Care. 2011;15(1):R58.
    • (2011) Crit Care. , vol.15 , Issue.1 , pp. R58
    • Bo, L.1    Wang, F.2    Zhu, J.3    Li, J.4    Deng, X.5
  • 112
    • 0028046930 scopus 로고
    • Effect of interferon gamma on infection-related death in patients with severe injuries. A randomized, double-blind, placebo-controlled trial
    • Dries DJ, et al. Effect of interferon gamma on infection-related death in patients with severe injuries. A randomized, double-blind, placebo-controlled trial. Arch Surg. 1994;129(10):1031-1041.
    • (1994) Arch Surg. , vol.129 , Issue.10 , pp. 1031-1041
    • Dries, D.J.1
  • 113
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;13(4):227-242.
    • (2013) Nat Rev Immunol. , vol.13 , Issue.4 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 114
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006;443(7109):350-354.
    • (2006) Nature. , vol.443 , Issue.7109 , pp. 350-354
    • Day, C.L.1
  • 115
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-2454.
    • (2012) N Engl J Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1
  • 116
    • 79951947339 scopus 로고    scopus 로고
    • Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients
    • Zhang Y, et al. Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients. Crit Care. 2011;15(1):R70.
    • (2011) Crit Care. , vol.15 , Issue.1 , pp. R70
    • Zhang, Y.1
  • 117
    • 84932177596 scopus 로고    scopus 로고
    • Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: An animal study and a prospective case-control study
    • Wang JF, et al. Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case-control study. Anesthesiology. 2015;122(4):852-863.
    • (2015) Anesthesiology. , vol.122 , Issue.4 , pp. 852-863
    • Wang, J.F.1
  • 118
    • 84877262213 scopus 로고    scopus 로고
    • Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis
    • Chang KC, et al. Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care. 2013;17(3):R85.
    • (2013) Crit Care. , vol.17 , Issue.3 , pp. R85
    • Chang, K.C.1
  • 119
    • 79955418828 scopus 로고    scopus 로고
    • Harnessing the biology of IL-7 for therapeutic application
    • Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol. 2011;11(5):330-342.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.5 , pp. 330-342
    • Mackall, C.L.1    Fry, T.J.2    Gress, R.E.3
  • 120
    • 84870727272 scopus 로고    scopus 로고
    • Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
    • Perales MA, et al. Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood. 2012;120(24):4882-4891.
    • (2012) Blood. , vol.120 , Issue.24 , pp. 4882-4891
    • Perales, M.A.1
  • 121
    • 84929206746 scopus 로고    scopus 로고
    • STAT5 phosphorylation in T cell subsets from septic patients in response to recombinant human interleukin-7: A pilot study
    • Demaret J, et al. STAT5 phosphorylation in T cell subsets from septic patients in response to recombinant human interleukin-7: A pilot study. J Leukoc Biol. 2015;97(4):791-796.
    • (2015) J Leukoc Biol. , vol.97 , Issue.4 , pp. 791-796
    • Demaret, J.1
  • 122
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter AL, et al. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol. 2008;181(10):6738-6746.
    • (2008) J Immunol. , vol.181 , Issue.10 , pp. 6738-6746
    • Kinter, A.L.1
  • 123
    • 84864125153 scopus 로고    scopus 로고
    • Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study
    • Levy Y, et al. Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clin Infect Dis. 2012;55(2):291-300.
    • (2012) Clin Infect Dis. , vol.55 , Issue.2 , pp. 291-300
    • Levy, Y.1
  • 124
    • 0037021446 scopus 로고    scopus 로고
    • Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: Role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2
    • Pelletier M, Ratthe C, Girard D. Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. FEBS Lett. 2002;532(1-2):164-170.
    • (2002) FEBS Lett. , vol.532 , Issue.1-2 , pp. 164-170
    • Pelletier, M.1    Ratthe, C.2    Girard, D.3
  • 125
    • 77949317183 scopus 로고    scopus 로고
    • IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
    • Inoue S, et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol. 2010;184(3):1401-1409.
    • (2010) J Immunol. , vol.184 , Issue.3 , pp. 1401-1409
    • Inoue, S.1
  • 126
    • 84924953319 scopus 로고    scopus 로고
    • Evolutionary insights into host-pathogen interactions from mammalian sequence data
    • Sironi M, Cagliani R, Forni D, Clerici M. Evolutionary insights into host-pathogen interactions from mammalian sequence data. Nat Rev Genet. 2015;16(4):224-236.
    • (2015) Nat Rev Genet. , vol.16 , Issue.4 , pp. 224-236
    • Sironi, M.1    Cagliani, R.2    Forni, D.3    Clerici, M.4


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