Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent

Blood

Volumn 124, Issue 24, 2014, Pages 3515-3523

  Lerman, Yelena V ^a,b   Lim, Kihong ^a   Hyun, Young Min ^a   Falkner, Kathleen L ^b   Yang, Hongmei ^b   Pietropaoli, Anthony P ^b   Sonnenberg, Arnoud ^c   Sarangi, Pranita P ^a,d   Kim, Minsoo ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; VERY LATE ACTIVATION ANTIGEN 3; CYTOKINE; PEPTIDE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASEMENT MEMBRANE; CELL MIGRATION; CIRCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; GRANULOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; LETHALITY; MALE; MOUSE; MOUSE MODEL; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; PATHOLOGY;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; INTEGRIN ALPHA3BETA1; MALE; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; PEPTIDES; SEPSIS; TOLL-LIKE RECEPTORS;

EID: 84916202796     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-01-552943     Document Type: Article

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