Functional genomics identifies type i interferon pathway as central for host defense against Candida albicans

Nature Communications

Volumn 4, Issue , 2013, Pages

  Smeekens, Sanne P ^a   Ng, Aylwin ^b,c   Kumar, Vinod ^d   Johnson, Melissa D ^e,f   Plantinga, Theo S ^a   Van Diemen, Cleo ^d   Arts, Peer ^a   Verwiel, Eugène T P ^a   Gresnigt, Mark S ^a   Fransen, Karin ^d   Van Sommeren, Suzanne ^d   Oosting, Marije ^a   Cheng, Shih Chin ^a   Joosten, Leo A B ^a   Hoischen, Alexander ^a   Kullberg, Bart Jan ^a   Scott, William K ^g   Perfect, John R ^e,f   Van Der Meer, Jos W M ^a   Wijmenga, Cisca ^d   Netea, Mihai G ^a   Xavier, Ramnik J ^b,c   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f Campbell University   (United States)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; STAT1 PROTEIN; STAT2 PROTEIN; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA;

BLOOD; FUNGAL DISEASE; GENE EXPRESSION; GENOME; HUMAN GEOGRAPHY; INFECTIOUS DISEASE; PATHOGEN; PUBLIC HEALTH;

ADULT; ARTICLE; CANDIDA ALBICANS; CANDIDEMIA; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RESPONSE; DNA POLYMORPHISM; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENETIC VARIABILITY; HOST RESISTANCE; HUMAN; IN VITRO STUDY; INFLAMMATION; MAJOR CLINICAL STUDY; MUCOCUTANEOUS CANDIDIASIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL; TH17 CELL; CASE CONTROL STUDY; CLUSTER ANALYSIS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; GENETICS; GENOMICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; MICROBIOLOGY; MUTATION; SIGNAL TRANSDUCTION;

CANADA;

CANDIDA ALBICANS; CANDIDEMIA; CANDIDIASIS, CHRONIC MUCOCUTANEOUS; CASE-CONTROL STUDIES; CLUSTER ANALYSIS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON TYPE I; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TH1 CELLS; TH17 CELLS; TRANSCRIPTION, GENETIC;

MLCS; MLOWN;

EID: 84878700149     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2343     Document Type: Article

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