Early alterations of B cells in patients with septic shock

Critical Care

Volumn 17, Issue 3, 2013, Pages

  Monserrat, Jorge ^a   de Pablo, Raul ^a,b   Diaz Martín, David ^a   Rodríguez Zapata, Manuel ^a,c   de la Hera, Antonio ^a   Prieto, Alfredo ^a   Alvarez Mon, Melchor ^a,b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^c HOSPITAL UNIVERSITARIO DE GUADALAJARA   (Spain)

Author keywords

Apoptosis; B cells; Flow cytometry; Lymphocyte; Lymphocyte activation; Phenotype; Sepsis; Septic shock

Indexed keywords

CD19 ANTIGEN; CD23 ANTIGEN; CD40 LIGAND;

ADULT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; NORMAL HUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY ANALYSIS; SEPTIC SHOCK; SURVIVOR; AGED; BLOOD; METABOLISM; MIDDLE AGED; SHOCK, SEPTIC; SURVIVAL RATE; TIME; TRENDS;

AGED; B-LYMPHOCYTES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SHOCK, SEPTIC; SURVIVAL RATE; TIME FACTORS;

EID: 84878243507     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc12750     Document Type: Article

References (43)

1. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-150. 10.1056/NEJMra021333, 12519925.
2. Russell JA. Management of sepsis. N Engl J Med 2006, 355:1699-1713. 10.1056/NEJMra043632, 17050894.
3. Döcke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W. Monocyte deactivation in septic patients: restoration by IFN-γ treatment. Nat Med 1997, 3:678-681. 10.1038/nm0697-678, 9176497.
4. de Pablo R, Monserrat J, Torrijos C, Martín M, Prieto A, Alvarez-Mon M. The predictive role of early activation of natural killer cells in septic shock. Crit Care 2012, 16:413. 10.1186/cc11204, 3681341, 22405329.
5. Kasten KR, Tschöp J, Adediran SG, Hildeman DA, Caldwell CC. T cells are potent early mediators of the host response to sepsis. Shock 2010, 34:327-336. 10.1097/SHK.0b013e3181e14c2e, 20386500.
6. Monserrat J, de Pablo R, Reyes E, Díaz D, Barcenilla H, Zapata MR, De la Hera A, Prieto A, Alvarez-Mon M. Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients. Crit Care 2009, 13:R26. 10.1186/cc7731, 2688144, 19243622.
7. Frasca D, Blomberg BB. Aging affects human B cell responses. J Clin Immunol 2011, 31:430-435. 10.1007/s10875-010-9501-7, 21318330.
8. Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol 2001, 19:595-621. 10.1146/annurev.immunol.19.1.595, 11244048.
9. Sanz I, Wei C, Lee FE, Anolik J. Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol 2008, 20:67-82. 10.1016/j.smim.2007.12.006, 2440717, 18258454.
10. Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournilhac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004, 104:3647-3654. 10.1182/blood-2004-01-0346, 2590648, 15191950.
11. Zouali M, Richard Y. Marginal zone B-cells, a gatekeeper of innate immunity. Front Immunol 2011, 2:63. 3341996, 22566852.
12. Haas KM, Poe JC, Steeber DA, Tedder TF. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 2005, 23:7-18. 10.1016/j.immuni.2005.04.011, 16039575.
13. Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med 2011, 208:1673-1682. 10.1084/jem.20101715, 3149216, 21746813.
14. Vaughan AT, Roghanian A, Cragg MS. B cells: masters of the immunoverse. Int J Biochem Cell Biol 2011, 43:280-285. 10.1016/j.biocel.2010.12.005, 21147251.
15. Booth J, Wilson H, Jimbo S, Mutwiri G. Modulation of B cell responses by Toll-like receptors. Cell Tissue Res 2011, 343:131-140. 10.1007/s00441-010-1031-3, 20824286.
16. Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol 2012, 30:221-241. 10.1146/annurev-immunol-020711-074934, 22224776.
17. Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat Rev Immunol 2012, 12:282-294. 10.1038/nri3190, 3437941, 22421786.
18. Darton TC, Wing JB, Lees A, Heath AW, Read RC. Adult survivors of invasive pneumococcal disease exhibit defective B cell function. Clin Infect Dis 2011, 52:1133-1136. 10.1093/cid/cir126, 3106266, 21467018.
19. Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells protect against microbial sepsis. Science 2012, 335:597-601. 10.1126/science.1215173, 3279743, 22245738.
20. Robbins CS, Swirski FK. Newly discovered innate response activator B cells: crucial responders against microbial sepsis. Expert Rev Clin Immunol 2012, 8:405-407. 10.1586/eci.12.32, 22882214.
21. Shubin NJ, Monaghan SF, Ayala A. Anti-inflammatory mechanisms of sepsis. Contrib Microbiol 2011, 17:108-124.
22. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
23. Böyum AJ. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968, 21:77-89. 10.3109/00365516809076979, 5637478.
24. Venet F, Davin F, Guignant C, Larue A, Cazalis MA, Darbon R, Allombert C, Mougin B, Malcus C, Poitevin-Later F, Lepape A, Monneret G. Early assessment of leukocyte alterations at diagnosis of septic shock. Shock 2010, 34:358-363. 10.1097/SHK.0b013e3181dc0977, 20220566.
25. Hotchkiss RS, Tinsley KW, Swanson PE, Schmieg RE, Hui JJ, Chang KC, Osborne DF, Freeman BD, Cobb JP, Buchman TG, Karl IE. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 2001, 166:6952-6963.
26. Jiménez-Ibáñez EO, Castillejos-López M, Hernández A, Gorocica P, Alvarado-Vásquez N. High mortality associated with hyperglycemia, neutrophilia, and lymphopenia in critically ill patients. Tohoku J Exp Med 2012, 226:213-220. 10.1620/tjem.226.213, 22353790.
27. Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, Green JM. A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care 2012, 16:R112. 10.1186/cc11404, 3580670, 22742734.
28. Rosenwasser LJ, Meng J. Anti-CD23. Clin Rev Allergy Immunol 2005, 29:61-72. 10.1385/CRIAI:29:1:061, 16222084.
29. Nolan A, Kobayashi H, Naveed B, Kelly A, Hoshino Y, Hoshino S, Karulf MR, Rom WN, Weiden MD, Gold JA. Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis. PLoS One 2009, 4:e6600. 10.1371/journal.pone.0006600, 2719911, 19672303.
30. Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA. CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Am J Respir Crit Care Med 2008, 177:301-308. 10.1164/rccm.200703-515OC, 2218847, 17989345.
31. Flohé SB, Agrawal H, Schmitz D, Gertz M, Flohé S, Schade FU. Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J Leukoc Biol 2006, 79:473-481.
32. van der Poll T, van Zoelen MA, Wiersinga WJ. Regulation of pro- and anti-inflammatory host responses. Contrib Microbiol 2011, 17:125-136.
33. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006, 6:813-822. 10.1038/nri1943, 17039247.
34. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999, 27:1230-1251. 10.1097/00003246-199907000-00002, 10446814.
35. Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH, Cobb JP, Coopersmith C, Karl IE. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 2002, 168:2493-2500.
36. Roth G, Moser B, Krenn C, Brunner M, Haisjackl M, Almer G, Gerlitz S, Wolner E, Boltz-Nitulescu G, Ankersmit HJ. Susceptibility to programmed cell death in T-lymphocytes from septic patients: a mechanism for lymphopenia and Th2 predominance. Biochem Biophys Res Commun 2003, 308:840-846. 10.1016/S0006-291X(03)01482-7, 12927795.
37. Gogos C, Kotsaki A, Pelekanou A, Giannikopoulos G, Vaki I, Maravitsa P, Adamis S, Alexiou Z, Andrianopoulos G, Antonopoulou A, Athanassia S, Baziaka F, Charalambous A, Christodoulou S, Dimopoulou I, Floros I, Giannitsioti E, Gkanas P, Ioakeimidou A, Kanellakopoulou K, Karabela N, Karagianni V, Katsarolis I, Kontopithari G, Kopterides P, Koutelidakis I, Koutoukas P, Kranidioti H, Lignos M, Louis K, et al. Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection. Crit Care 2010, 14:R96. 10.1186/cc9031, 2911733, 20504311.
38. Ongradi J, Kovesdi V. Numerical alterations of ageing B lymphocyte subsets. Acta Physiol Hung 2011, 98:99-104. 10.1556/APhysiol.98.2011.2.1, 21616768.
39. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
40. Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S, Working Group on "Sepsis-Related Problems" of the European Society of Intensive Care Medicine Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med 1998, 26:1793-1800. 10.1097/00003246-199811000-00016, 9824069, Working Group on "Sepsis-Related Problems" of the European Society of Intensive Care Medicine.
41. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995, 23:1638-1652. 10.1097/00003246-199510000-00007, 7587228.
42. Jacobs S, Zuleika M, Mphansa T. The Multiple Organ Dysfunction Score as a descriptor of patient outcome in septic shock compared with two other scoring systems. Crit Care Med 1999, 27:741-744. 10.1097/00003246-199904000-00027, 10321663.
43. Moreno R, Vincent JL, Matos R, de Mendonça A, Cantraine F, Thijs L, Takala J, Sprung C, Antonelli M, Bruining H, Willatts S, Working Group on Sepsis-Related Problems of the ESICM The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care: results of a prospective, multicentre study. Intensive Care Med 1999, 25:686-696. 10.1007/s001340050931, 10470572, Working Group on Sepsis-Related Problems of the ESICM.