Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock

Critical Care

Volumn 17, Issue 6, 2013, Pages

  Cazalis, Marie Angélique ^a   Friggeri, Arnaud ^a,b   Cavé, Laura ^a   Demaret, Julie ^a   Barbalat, Véronique ^a   Cerrato, Elisabeth ^a   Lepape, Alain ^a,b   Pachot, Alexandre ^a   Monneret, Guillaume ^a   Venet, Fabienne ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; BIOLOGICAL MARKER; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; INVARIANT CHAIN; LEUKOCYTE ANTIGEN; MESSENGER RNA;

AGED; BLOOD; FEMALE; HUMAN; MALE; MIDDLE AGED; MORTALITY; SEPTIC SHOCK;

AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BIOLOGICAL MARKERS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; RNA, MESSENGER; SHOCK, SEPTIC;

EID: 84891639053     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13150     Document Type: Article

References (20)

1. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-150. 10.1056/NEJMra021333, 12519925.
2. Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013, 13:260-268. 10.1016/S1473-3099(13)70001-X, 3798159, 23427891.
3. Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk HD. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009, 180:640-648. 10.1164/rccm.200903-0363OC, 19590022.
4. Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med 2008, 14:64-78. 2078557, 18026569.
5. Pachot A, Monneret G, Brion A, Venet F, Bohe J, Bienvenu J, Mougin B, Lepape A. Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Crit Care Med 2005, 33:31-38. 10.1097/01.CCM.0000150958.20209.A3, 15644645.
6. Payen D, Lukaszewicz AC, Belikova I, Faivre V, Gelin C, Russwurm S, Launay JM, Sevenet N. Gene profiling in human blood leucocytes during recovery from septic shock. Intensive Care Med 2008, 34:1371-1376. 10.1007/s00134-008-1048-1, 18392609.
7. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003, 2001:1250-1256.
8. Monneret G, Lepape A, Voirin N, Bohe J, Venet F, Debard AL, Thizy H, Bienvenu J, Gueyffier F, Vanhems P. Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 2006, 32:1175-1183. 10.1007/s00134-006-0204-8, 16741700.
9. Cotton EST Database: East Carolina. http://www.leonxie.com/referencegene.php.
10. Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, Vincent JL, Townsend S, Lemeshow S, Dellinger RP. Outcomes of the surviving sepsis campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis 2012, 12:919-924. 10.1016/S1473-3099(12)70239-6, 23103175.
11. Reinhart K, Bauer M, Riedemann NC, Hartog CS. New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev 2012, 25:609-634. 10.1128/CMR.00016-12, 3485751, 23034322.
12. Skrupky LP, Kerby PW, Hotchkiss RS. Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology 2011, 115:1349-1362. 3433833, 21952252.
13. Hotchkiss RS, Opal S. Immunotherapy for sepsis - a new approach against an ancient foe. N Engl J Med 2010, 363:87-89. 10.1056/NEJMcibr1004371, 20592301.
14. Choi NM, Majumder P, Boss JM. Regulation of major histocompatibility complex class II genes. Curr Opin Immunol 2011, 23:81-87. 10.1016/j.coi.2010.09.007, 3033992, 20970972.
15. Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, Weber SU, Hedwig-Geissing M, Kreuzfelder E, Tschentscher P, Nebe T, Engel A, Monneret G, Spittler A, Schmolke K, Reinke P, Volk HD, Kunz D. Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study. Clin Chem 2005, 51:2341-2347. 10.1373/clinchem.2005.052639, 16214828.
16. Monneret G, Elmenkouri N, Bohe J, Debard AL, Gutowski MC, Bienvenu J, Lepape A. Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock. Clin Chem 2002, 48:1589-1592.
17. Le Tulzo Y, Pangault C, Amiot L, Guilloux V, Tribut O, Arvieux C, Camus C, Fauchet R, Thomas R, Drenou B. Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock. Am J Respir Crit Care Med 2004, 169:1144-1151. 10.1164/rccm.200309-1329OC, 15028560.
18. Hinrichs C, Kotsch K, Buchwald S, Habicher M, Saak N, Gerlach H, Volk HD, Keh D. Perioperative gene expression analysis for prediction of postoperative sepsis. Clin Chem 2010, 56:613-622. 10.1373/clinchem.2009.133876, 20133891.
19. Marshall JC, Reinhart K. Biomarkers of sepsis. Crit Care Med 2009, 37:2290-2298. 10.1097/CCM.0b013e3181a02afc, 19487943.
20. Turrel-Davin F, Venet F, Monnin C, Barbalat V, Cerrato E, Pachot A, Lepape A, Alberti-Segui C, Monneret G. mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Crit Care 2011, 15:R252. 10.1186/cc10513, 3334803, 22027436.