Numerical investigation of dynamic microorgan devices as drug screening platforms. Part I: Macroscale modeling approach & validation

Biotechnology and Bioengineering

Volumn 113, Issue 3, 2016, Pages 612-622

  Tourlomousis, Filippos ^a   Chang, Robert C ^a  

^a Stevens Institute of Technology   (United States)

Author keywords

3D bioprinting; Bioreactor; HepG2 cells; Liver on a chip; Mechanotransduction; Tissue on a chip

Indexed keywords

3D PRINTERS; BIOREACTORS; DIFFUSION IN LIQUIDS; ENZYMES; HEAT CONVECTION; HYDROGELS; LARGE SCALE SYSTEMS; METABOLISM; PHYSIOLOGY; REACTION KINETICS; REACTION RATES; SHEAR STRESS; TISSUE;

BIOPRINTING; CONVECTION DIFFUSION; CONVECTION-DIFFUSION EQUATIONS; HEP-G2 CELLS; KEY DESIGN PARAMETERS; MECHANOTRANSDUCTION; NUMERICAL INVESTIGATIONS; TRANSIENT SIMULATION;

SHEAR FLOW;

ARTICLE; CELL ENCAPSULATION; CELL VIABILITY; CONCENTRATION AT STEADY-STATE; DYNAMIC MICROORGAN DEVICE; ENZYME MECHANISM; HUMAN; HYDRODYNAMICS; HYDROGEL; LIVER CELL; MECHANOTRANSDUCTION; MEDICAL DEVICE; MICHAELIS CONSTANT; SHEAR STRESS; THERMODYNAMICS; VELOCITY; VISCOSITY; BIOLOGICAL MODEL; DRUG EFFECTS; HEP-G2 CELL LINE; LIVER; METABOLISM; ORGAN CULTURE TECHNIQUE; PRECLINICAL STUDY; PROCEDURES;

DRUG EVALUATION, PRECLINICAL; HEP G2 CELLS; HUMANS; LIVER; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES;

EID: 84955640418     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25822     Document Type: Article

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