In vivo clearance of ethoxycoumarin and its prediction from in vitro systems: Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

Drug Metabolism and Disposition

Volumn 26, Issue 3, 1998, Pages 216-221

  Carlile, David J ^b   Stevens, Alex J ^b   Ashforth, Elizabeth I L ^b   Waghela, Daxa ^b   Houston, J Brian ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN DERIVATIVE; ETHOXYCOUMARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; LIVER CELL; LIVER MICROSOME METABOLISM; MALE; MICHAELIS CONSTANT; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; COUMARINS; KINETICS; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; UMBELLIFERONES;

EID: 0031895693     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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