메뉴 건너뛰기




Volumn 40, Issue 6, 2012, Pages 1244-1254

Microfluidic platforms for hepatocyte cell culture: New technologies and applications

Author keywords

3D cell culture; Drug discovery; In vivo like cell culture; Liver toxicity; Perfusion

Indexed keywords

3-D CELL CULTURE; DESIGN REQUIREMENTS; DRUG DISCOVERY; HEPATOCYTES; IN-VIVO; KEY ELEMENTS; LIVER TOXICITY; MICROFLUIDIC PLATFORMS; PERFUSION;

EID: 84862146642     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-011-0453-8     Document Type: Article
Times cited : (22)

References (82)
  • 1
    • 0042358985 scopus 로고    scopus 로고
    • Biology's new dimension
    • DOI 10.1038/424870a
    • A Abbott 2003 Cell culture: biology's new dimension Nature 424 870 875 12931155 10.1038/424870a 1:CAS:528:DC%2BD3sXmsV2ju7o%3D (Pubitemid 37051657)
    • (2003) Nature , vol.424 , Issue.6951 , pp. 870-872
    • Abbott, A.1
  • 2
    • 14844320510 scopus 로고    scopus 로고
    • In vitro zonation and toxicity in a hepatocyte bioreactor
    • DOI 10.1093/toxsci/kfi052
    • JW Allen SR Khetani S Bhatia 2005 In vitro zonation and toxicity in a hepatocyte bioreactor Toxicol. Sci. 84 110 119 15590888 10.1093/toxsci/kfi052 1:CAS:528:DC%2BD2MXhsFSnsbY%3D (Pubitemid 40340278)
    • (2005) Toxicological Sciences , vol.84 , Issue.1 , pp. 110-119
    • Allen, J.W.1    Khetani, S.R.2    Bhatia, S.N.3
  • 3
    • 78851471723 scopus 로고    scopus 로고
    • Effects of shear stress and stretch on endothelial function
    • 20854012 10.1089/ars.2010.3361 1:CAS:528:DC%2BC3MXpsVOkt7s%3D
    • J Ando K Yamamoto 2011 Effects of shear stress and stretch on endothelial function Antioxid. Redox Signal. 15 1389 1403 20854012 10.1089/ars.2010.3361 1:CAS:528:DC%2BC3MXpsVOkt7s%3D
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 1389-1403
    • Ando, J.1    Yamamoto, K.2
  • 5
    • 0032721936 scopus 로고    scopus 로고
    • Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
    • SN Bhatia UJ Balis ML Yarmush M Toner 1999 Effect of cell-cell interactions in preservations of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells FASEB J. 13 1883 1900 10544172 1:CAS:528:DyaK1MXnt1GntLY%3D (Pubitemid 29517619)
    • (1999) FASEB Journal , vol.13 , Issue.14 , pp. 1883-1900
    • Bhatia, S.N.1    Balis, U.J.2    Yarmush, M.L.3    Toner, M.4
  • 6
    • 77952011208 scopus 로고    scopus 로고
    • Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions: Sixth international bio-fluid mechanics symposium and workshop March 28-30, 2008 Pasadena, California
    • 20336839 10.1007/s10439-010-9899-3
    • S Chung R Sudo V Vickerman IK Zervantonakis RD Kamm 2010 Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions: sixth international bio-fluid mechanics symposium and workshop March 28-30, 2008 Pasadena, California Ann. Biomed. Eng. 38 1164 1177 20336839 10.1007/s10439-010-9899-3
    • (2010) Ann. Biomed. Eng. , vol.38 , pp. 1164-1177
    • Chung, S.1    Sudo, R.2    Vickerman, V.3    Zervantonakis, I.K.4    Kamm, R.D.5
  • 7
    • 0033956082 scopus 로고    scopus 로고
    • A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: Cell viability and tissue-specific functions
    • DOI 10.1021/bp990128o
    • L De Bartolo G Jarosch-Von Schweder A Haverich A Bader 2000 A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions Biotechnol. Prog. 16 102 108 10662497 10.1021/bp990128o (Pubitemid 30097658)
    • (2000) Biotechnology Progress , vol.16 , Issue.1 , pp. 102-108
    • De Bartolo, L.1    Jarosch-Von Schweder, G.2    Haverich, A.3    Bader, A.4
  • 8
    • 0026785499 scopus 로고
    • A perifusion system for cultured hepatocytes
    • 1456444 10.1016/S0003-2697(05)80012-0 1:CAS:528:DyaK38XlvVOnur0%3D
    • J Dich N Grunnet 1992 A perifusion system for cultured hepatocytes Anal. Biochem. 206 68 72 1456444 10.1016/S0003-2697(05)80012-0 1:CAS:528: DyaK38XlvVOnur0%3D
    • (1992) Anal. Biochem. , vol.206 , pp. 68-72
    • Dich, J.1    Grunnet, N.2
  • 9
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DOI 10.1016/S0167-6296(02)00126-1
    • JA DiMasi RW Hansen HG Grabowski 2003 The price of innovation: new estimates of drug development costs J. Health Econ. 22 151 185 12606142 10.1016/S0167-6296(02)00126-1 (Pubitemid 36279392)
    • (2003) Journal of Health Economics , vol.22 , Issue.2 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 10
    • 33644777646 scopus 로고    scopus 로고
    • Lab-on-a-chip: Microfluidics in drug discovery
    • DOI 10.1038/nrd1985, PII N1985
    • PS Dittrich A Manz 2006 Lab-on-a-chip: microfluidics in drug discovery Nat. Rev. Drug Discov. 5 210 218 16518374 10.1038/nrd1985 1:CAS:528: DC%2BD28XhvFOlsrw%3D (Pubitemid 43336034)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.3 , pp. 210-218
    • Dittrich, P.S.1    Manz, A.2
  • 11
    • 79958864582 scopus 로고    scopus 로고
    • High fluid shear stress and spatial shear stress gradients affect endothelial proliferation, survival, and alignment
    • 21312062 10.1007/s10439-011-0267-8
    • JM Dolan H Meng S Singh R Paluch J Kolega 2011 High fluid shear stress and spatial shear stress gradients affect endothelial proliferation, survival, and alignment Ann. Biomed. Eng. 39 1620 1631 21312062 10.1007/s10439-011-0267-8
    • (2011) Ann. Biomed. Eng. , vol.39 , pp. 1620-1631
    • Dolan, J.M.1    Meng, H.2    Singh, S.3    Paluch, R.4    Kolega, J.5
  • 12
    • 77951919817 scopus 로고    scopus 로고
    • Perfused multiwell plate for 3D liver tissue engineering
    • 20024050 10.1039/b913221j 1:CAS:528:DC%2BD1MXhsFaksLfL
    • K Domansky W Inman J Serdy A Dash MHM Lim LG Griffith 2010 Perfused multiwell plate for 3D liver tissue engineering Lab Chip 10 51 58 20024050 10.1039/b913221j 1:CAS:528:DC%2BD1MXhsFaksLfL
    • (2010) Lab Chip , vol.10 , pp. 51-58
    • Domansky, K.1    Inman, W.2    Serdy, J.3    Dash, A.4    Lim, M.H.M.5    Griffith, L.G.6
  • 13
    • 77952361683 scopus 로고    scopus 로고
    • Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane
    • 10.1089/ten.tec.2009.0042 1:CAS:528:DC%2BC3cXkt1ChtLk%3D
    • F Evenou T Fujii Y Sakai 2010 Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane Tissue Eng. C 16 311 318 10.1089/ten.tec.2009.0042 1:CAS:528:DC%2BC3cXkt1ChtLk%3D
    • (2010) Tissue Eng. C , vol.16 , pp. 311-318
    • Evenou, F.1    Fujii, T.2    Sakai, Y.3
  • 14
    • 79961027871 scopus 로고    scopus 로고
    • Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues
    • doi: 10.1002/btpr.626
    • Evenou, F., M. Hamon, T. Fujii, S. Takeuchi, and Y. Sakai. Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues. Biotechnol. Prog, 2011. doi: 10.1002/btpr.626.
    • (2011) Biotechnol. Prog
    • Evenou, F.1    Hamon, M.2    Fujii, T.3    Takeuchi, S.4    Sakai, Y.5
  • 15
    • 0030778204 scopus 로고    scopus 로고
    • Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion
    • DOI 10.1073/pnas.94.23.12258
    • K Francis BO Palsson 1997 Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion Proc. Natl. Acad. Sci. USA 94 12258 12262 9356436 10.1073/pnas.94.23. 12258 1:CAS:528:DyaK2sXns1ylsrw%3D (Pubitemid 27492515)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.23 , pp. 12258-12262
    • Francis, K.1    Palsson, B.O.2
  • 16
    • 0642315067 scopus 로고    scopus 로고
    • Perfusion culture of hepatocytes
    • 14577242 1:CAS:528:DyaK1cXmvVemtrc%3D
    • R Gebhardt 1998 Perfusion culture of hepatocytes Methods Mol. Biol. 107 329 339 14577242 1:CAS:528:DyaK1cXmvVemtrc%3D
    • (1998) Methods Mol. Biol. , vol.107 , pp. 329-339
    • Gebhardt, R.1
  • 17
    • 0018614841 scopus 로고
    • Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis
    • DOI 10.1016/0014-4827(79)90210-6
    • R Gebhardt D Mecke 1979 Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis Exp. Cell Res. 124 349 359 389647 10.1016/0014-4827(79)90210-6 1:CAS:528:DyaL3cXlsFOguw%3D%3D (Pubitemid 10177371)
    • (1979) Experimental Cell Research , vol.124 , Issue.2 , pp. 349-359
    • Gebhardt, R.1    Mecke, D.2
  • 18
    • 78649509613 scopus 로고    scopus 로고
    • Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants
    • 10.1039/c0lc00135j
    • VN Goral YC Hsieh ON Petzold JS Clark PK Yuen RA Faris 2010 Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants Lab Chip 10 3309 3432 10.1039/c0lc00135j
    • (2010) Lab Chip , vol.10 , pp. 3309-3432
    • Goral, V.N.1    Hsieh, Y.C.2    Petzold, O.N.3    Clark, J.S.4    Yuen, P.K.5    Faris, R.A.6
  • 20
    • 79952114647 scopus 로고    scopus 로고
    • Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering
    • 20823504 10.1088/1758-5082/2/3/035003
    • CM Hwang S Sant M Masaeli NN Kachouie B Zamanian SH Lee A Khademhosseini 2010 Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering Biofabrication 2 035003 20823504 10.1088/1758-5082/2/3/035003
    • (2010) Biofabrication , vol.2 , pp. 035003
    • Hwang, C.M.1    Sant, S.2    Masaeli, M.3    Kachouie, N.N.4    Zamanian, B.5    Lee, S.H.6    Khademhosseini, A.7
  • 21
    • 0017136798 scopus 로고
    • Diffusion in tissue cultures on gas-permeable and impermeable supports
    • 5633 10.1016/S0022-5193(76)80085-9 1:CAS:528:DyaE28XhsVOhtrY%3D
    • MD Jensen DFH Wallach P Sherwood 1976 Diffusion in tissue cultures on gas-permeable and impermeable supports J. Theor. Biol. 56 443 458 5633 10.1016/S0022-5193(76)80085-9 1:CAS:528:DyaE28XhsVOhtrY%3D
    • (1976) J. Theor. Biol. , vol.56 , pp. 443-458
    • Jensen, M.D.1    Wallach, D.F.H.2    Sherwood, P.3
  • 22
    • 0018131499 scopus 로고
    • Heterogeneity of liver parenchymal cells
    • K Jungermann D Sasse 1978 Heterogeneity of liver parenchymal cells Trends Biochem. Sci. 3 198 202 10.1016/S0968-0004(78)91764-4 1:CAS:528: DyaE1cXls1Sls74%3D (Pubitemid 9011796)
    • (1978) Trends in Biochemical Sciences , vol.3 , Issue.9 , pp. 198-202
    • Jungermann, K.1    Sasse, D.2
  • 23
    • 33745686447 scopus 로고    scopus 로고
    • Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes
    • 16808435 10.1021/ac051856v 1:CAS:528:DC%2BD28XlsFaksbw%3D
    • BJ Kane MJ Zinner ML Yarmush M Toner 2006 Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes Anal. Chem. 78 4291 4298 16808435 10.1021/ac051856v 1:CAS:528:DC%2BD28XlsFaksbw%3D
    • (2006) Anal. Chem. , vol.78 , pp. 4291-4298
    • Kane, B.J.1    Zinner, M.J.2    Yarmush, M.L.3    Toner, M.4
  • 24
    • 4544247564 scopus 로고    scopus 로고
    • Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
    • DOI 10.1002/hep.20351
    • SR Khetani G Szulgit JA Del Rio C Barlow SN Bhatia 2004 Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling Hepatology 40 545 554 15349892 10.1002/hep.20351 1:CAS:528:DC%2BD2cXot1Ortr8%3D (Pubitemid 39265575)
    • (2004) Hepatology , vol.40 , Issue.3 , pp. 545-554
    • Khetani, S.R.1    Szulgit, G.2    Del Rio, J.A.3    Barlow, C.4    Bhatia, S.N.5
  • 25
    • 70349466841 scopus 로고    scopus 로고
    • Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance
    • 19720996 10.1073/pnas.0906820106 1:CAS:528:DC%2BD1MXhtFyjsLnI
    • S Kidambi RS Yarmush E Novik P Chao ML Yarmush Y Nahmias 2009 Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance Proc. Natl. Acad. Sci. USA 106 15714 15719 19720996 10.1073/pnas.0906820106 1:CAS:528:DC%2BD1MXhtFyjsLnI
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 15714-15719
    • Kidambi, S.1    Yarmush, R.S.2    Novik, E.3    Chao, P.4    Yarmush, M.L.5    Nahmias, Y.6
  • 26
    • 56449113183 scopus 로고    scopus 로고
    • Microvalve-assisted patterning platform for measuring cellular dynamics based on 3D cell culture
    • 18942775 10.1002/bit.21962 1:CAS:528:DC%2BD1cXhsVWktLnE
    • MS Kim W Lee YC Kim J-K Park 2008 Microvalve-assisted patterning platform for measuring cellular dynamics based on 3D cell culture Biotechnol. Bioeng. 101 1005 1013 18942775 10.1002/bit.21962 1:CAS:528:DC%2BD1cXhsVWktLnE
    • (2008) Biotechnol. Bioeng. , vol.101 , pp. 1005-1013
    • Kim, M.S.1    Lee, W.2    Kim, Y.C.3    Park, J.-K.4
  • 27
    • 33846032329 scopus 로고    scopus 로고
    • A microfluidic platform for 3-dimensional cell culture and cell-based assays
    • DOI 10.1007/s10544-006-9016-4
    • MS Kim JH Yeon JK Park 2007 A microfluidic platform for 3-dimensional cell culture and cell-based assays Biomed. Microdevices 9 25 34 17103048 10.1007/s10544-006-9016-4 1:CAS:528:DC%2BD2sXht12ltA%3D%3D (Pubitemid 46050126)
    • (2007) Biomedical Microdevices , vol.9 , Issue.1 , pp. 25-34
    • Kim, M.S.1    Yeon, J.H.2    Park, J.-K.3
  • 28
    • 60549095805 scopus 로고    scopus 로고
    • Design of well and groove microchannel bioreactors for cell culture
    • 18973280 10.1002/bit.22153 1:CAS:528:DC%2BD1MXhvFGhs7k%3D
    • N Korin A Bransky M Khoury U Dinnar S Levenberg 2009 Design of well and groove microchannel bioreactors for cell culture Biotechnol. Bioeng. 102 1222 1230 18973280 10.1002/bit.22153 1:CAS:528:DC%2BD1MXhvFGhs7k%3D
    • (2009) Biotechnol. Bioeng. , vol.102 , pp. 1222-1230
    • Korin, N.1    Bransky, A.2    Khoury, M.3    Dinnar, U.4    Levenberg, S.5
  • 29
    • 79959502605 scopus 로고    scopus 로고
    • Controlling mass transport in microfluidic devices
    • 10.1146/annurev-anchem-061010-113926 1:CAS:528:DC%2BC3MXhtVynsbbN
    • JS Kuo DT Chiu 2011 Controlling mass transport in microfluidic devices Annu. Rev. Anal. Chem. 4 275 296 10.1146/annurev-anchem-061010-113926 1:CAS:528:DC%2BC3MXhtVynsbbN
    • (2011) Annu. Rev. Anal. Chem. , vol.4 , pp. 275-296
    • Kuo, J.S.1    Chiu, D.T.2
  • 30
    • 0035686143 scopus 로고    scopus 로고
    • Adult rat hepatocytes cultured on an oxygen-permeable film increases the activity of albumin secretion
    • DOI 10.1023/A:1014028617729
    • H Kurosawa R Yasuda YK Osano Y Amano 2001 Adult rat hepatocytes cultured on an oxygen-permeable film increases the activity of albumin secretion Cytotechnology 36 85 92 19003318 10.1023/A:1014028617729 1:CAS:528: DC%2BD38XovV2ktw%3D%3D (Pubitemid 34067715)
    • (2001) Cytotechnology , vol.36 , Issue.1-3 , pp. 85-92
    • Kurosawa, H.1    Yasuda, R.2    Osano, Y.-K.3    Amano, Y.4
  • 31
    • 77952958460 scopus 로고    scopus 로고
    • Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism
    • 20171269 10.1016/j.tiv.2010.02.015 1:CAS:528:DC%2BC3cXmtFersL4%3D
    • S-F Lan B Safiejko-Mroczka B Starly 2010 Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: a study of cell viability, morphology and drug metabolism Toxicol. In Vitro 24 1314 1323 20171269 10.1016/j.tiv.2010.02.015 1:CAS:528:DC%2BC3cXmtFersL4%3D
    • (2010) Toxicol. in Vitro , vol.24 , pp. 1314-1323
    • Lan, S.-F.1    Safiejko-Mroczka, B.2    Starly, B.3
  • 32
    • 0022204028 scopus 로고
    • Spheroidal aggregate culture of rat liver cells: Histotypic reorganization, biomatrix deposition, and maintenance of functional activities
    • DOI 10.1083/jcb.101.3.914
    • J Landry D Bernier C Ouellet R Goyette N Marceau 1985 Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities J. Cell Biol. 101 914 923 2411740 10.1083/jcb.101.3.914 1:STN:280:DyaL2M3ovFGiuw%3D%3D (Pubitemid 16256845)
    • (1985) Journal of Cell Biology , vol.101 , Issue.3 , pp. 914-923
    • Landry, J.1    Bernier, D.2    Ouellet, C.3
  • 33
    • 3042614049 scopus 로고    scopus 로고
    • Perfusion culture of fetal human hepatocytes in microfluidic environments
    • DOI 10.1016/j.bej.2003.09.010, PII S1369703X03002584
    • E Leclerc Y Sakai T Fujii 2004 Perfusion culture of fetal human hepatocytes in microfluidic environments Biochem. Eng. J. 20 143 148 10.1016/j.bej.2003.09.010 1:CAS:528:DC%2BD2cXltF2qt7o%3D (Pubitemid 38829558)
    • (2004) Biochemical Engineering Journal , vol.20 , Issue.2-3 , pp. 143-148
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 34
    • 0030588693 scopus 로고    scopus 로고
    • Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes
    • DOI 10.1016/S0169-409X(96)00418-8, PII S0169409X96004188
    • EL LeCluyse PL Bullock A Parkinson 1996 Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes Adv. Drug. Deliv. Rev. 22 133 186 10.1016/S0169-409X(96)00418-8 1:CAS:528:DyaK28Xnt1Klsrg%3D (Pubitemid 26423601)
    • (1996) Advanced Drug Delivery Reviews , vol.22 , Issue.1-2 , pp. 133-186
    • LeCluyse, E.L.1    Bullock, P.L.2    Parkinson, A.3
  • 36
    • 34547581758 scopus 로고    scopus 로고
    • An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
    • DOI 10.1002/bit.21360
    • PJ Lee PJ Hung LP Lee 2007 An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture Biotechnol. Bioeng. 97 1340 1346 17286266 10.1002/bit.21360 1:CAS:528:DC%2BD2sXnvFagur8%3D (Pubitemid 47195329)
    • (2007) Biotechnology and Bioengineering , vol.97 , Issue.5 , pp. 1340-1346
    • Lee, P.J.1    Hung, P.J.2    Lee, L.P.3
  • 37
    • 33645638151 scopus 로고    scopus 로고
    • The development of a microscale cell culture analog device for toxicity study
    • Cincinnati, OH
    • Li, X., and M. L. Shuler. The development of a microscale cell culture analog device for toxicity study. Conference Proceedings. AIChE Annual Meeting, Cincinnati, OH, 14197, 2005.
    • (2005) Conference Proceedings, AIChE Annual Meeting , pp. 14197
    • Li, X.1    Shuler, M.L.2
  • 38
    • 79955475917 scopus 로고    scopus 로고
    • Microfluidic cell coculture methods for understanding cell biology, analyzing bio/pharmaceuticals, and developing tissue constructs
    • 21354094 10.1016/j.ab.2011.02.027 1:CAS:528:DC%2BC3MXltFaisLo%3D
    • M Marimuthu S Kim 2011 Microfluidic cell coculture methods for understanding cell biology, analyzing bio/pharmaceuticals, and developing tissue constructs Anal. Biochem. 413 81 89 21354094 10.1016/j.ab.2011.02.027 1:CAS:528:DC%2BC3MXltFaisLo%3D
    • (2011) Anal. Biochem. , vol.413 , pp. 81-89
    • Marimuthu, M.1    Kim, S.2
  • 39
    • 0036255608 scopus 로고    scopus 로고
    • Morphological and biochemical integrity of human liver slices in long-term culture: Effects of oxygen tension
    • DOI 10.1023/A:1015379815897
    • H Martin JP Sarsat C Lerche-Langrand C Housset P Balladur H Toutain V Albaladejo 2002 Morphological and biochemical integrity of human liver slices in long-term culture: effects of oxygen tension Cell Biol. Toxicol. 18 73 85 12046692 10.1023/A:1015379815897 1:CAS:528:DC%2BD38XksFyrsro%3D (Pubitemid 34467940)
    • (2002) Cell Biology and Toxicology , vol.18 , Issue.2 , pp. 73-85
    • Martin, H.1    Sarsat, J.P.2    Lerche-Langrand, C.3    Housset, C.4    Balladur, P.5    Toutain, H.6    Albaladejo, V.7
  • 40
    • 77957954435 scopus 로고    scopus 로고
    • Rapid and enhanced repolarization in sandwich-cultured hepatocytes on an oxygen-permeable membrane
    • 10.1016/j.bej.2010.08.018 1:CAS:528:DC%2BC3cXhtlSnu7vN
    • H Matsui T Osada Y Moroshita M Sekijima T Fujii S Takeuchi Y Sakai 2010 Rapid and enhanced repolarization in sandwich-cultured hepatocytes on an oxygen-permeable membrane Biochem. Eng. J. 52 255 262 10.1016/j.bej.2010.08.018 1:CAS:528:DC%2BC3cXhtlSnu7vN
    • (2010) Biochem. Eng. J. , vol.52 , pp. 255-262
    • Matsui, H.1    Osada, T.2    Moroshita, Y.3    Sekijima, M.4    Fujii, T.5    Takeuchi, S.6    Sakai, Y.7
  • 41
    • 81255149619 scopus 로고    scopus 로고
    • Mechanical stimuli differentially control stem cell behavior: Morphology, proliferation, and differentiation
    • doi: 10.1007/s10237-010-0285-8
    • Maul, T. M., D. W. Chew, A. Nieponice, and D. A. Vorp. Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation. Biomech. Model. Mechanobiol. 2011. doi: 10.1007/s10237-010- 0285-8.
    • (2011) Biomech. Model. Mechanobiol.
    • Maul, T.M.1    Chew, D.W.2    Nieponice, A.3    Vorp, D.A.4
  • 42
    • 84984088596 scopus 로고
    • Kinetics of gas diffusion in mammalian cell culture systems. II. Theory
    • 10.1002/bit.260100604 1:CAS:528:DyaF1MXksFCqsw%3D%3D
    • WF McLimans LE Blumenson KV Tunnah 1968 Kinetics of gas diffusion in mammalian cell culture systems. II. Theory Biotechnol. Bioeng. 10 741 763 10.1002/bit.260100604 1:CAS:528:DyaF1MXksFCqsw%3D%3D
    • (1968) Biotechnol. Bioeng. , vol.10 , pp. 741-763
    • McLimans, W.F.1    Blumenson, L.E.2    Tunnah, K.V.3
  • 43
    • 33745184675 scopus 로고    scopus 로고
    • Systems model-based analysis and design of a microchannel reactor for tissue engineering
    • 16586504 10.1002/bit.20857 1:CAS:528:DC%2BD28XltF2msrc%3D
    • K Mehta JJ Linderman 2006 Systems model-based analysis and design of a microchannel reactor for tissue engineering Biotechnol. Bioeng. 94 596 609 16586504 10.1002/bit.20857 1:CAS:528:DC%2BD28XltF2msrc%3D
    • (2006) Biotechnol. Bioeng. , vol.94 , pp. 596-609
    • Mehta, K.1    Linderman, J.J.2
  • 45
    • 77449119885 scopus 로고    scopus 로고
    • A microfluidic hepatic coculture platform for cell-based drug metabolism studies
    • 19925779 10.1016/j.bcp.2009.11.010 1:CAS:528:DC%2BC3cXhtlais7Y%3D
    • E Novik TJ Maguire P Chao KC Cheng ML Yarmush 2010 A microfluidic hepatic coculture platform for cell-based drug metabolism studies Biochem. Pharmacol. 79 1036 1044 19925779 10.1016/j.bcp.2009.11.010 1:CAS:528:DC%2BC3cXhtlais7Y%3D
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1036-1044
    • Novik, E.1    Maguire, T.J.2    Chao, P.3    Cheng, K.C.4    Yarmush, M.L.5
  • 46
    • 0031972732 scopus 로고    scopus 로고
    • Zonation of hepatic cytochrome P-450 expression and regulation
    • T Oinonen KO Lindros 1998 Zonation of hepatic cytochrome P-450 expression and regulation Biochem. J. 329 17 35 9405271 1:CAS:528:DyaK1cXltFeisQ%3D%3D (Pubitemid 28022286)
    • (1998) Biochemical Journal , vol.329 , Issue.1 , pp. 17-35
    • Oinonen, T.1    Lindros, K.O.2
  • 48
    • 79953243156 scopus 로고    scopus 로고
    • A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening
    • 21295126 10.1016/j.ijpharm.2011.01.054 1:CAS:528:DC%2BC3MXktFahsrw%3D
    • JM Prot O Videau C Brochot C Legallais H Bénech E Leclerc 2011 A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening Int. J. Pharm. 408 67 75 21295126 10.1016/j.ijpharm.2011.01.054 1:CAS:528:DC%2BC3MXktFahsrw%3D
    • (2011) Int. J. Pharm. , vol.408 , pp. 67-75
    • Prot, J.M.1    Videau, O.2    Brochot, C.3    Legallais, C.4    Bénech, H.5    Leclerc, E.6
  • 49
    • 0027113009 scopus 로고
    • Oxygen uptake rates in cultured rat hepatocytes
    • 18601082 10.1002/bit.260401020 1:CAS:528:DyaK3sXksVan
    • A Rotem M Toner R Tompkins M Yarmush 1992 Oxygen uptake rates in cultured rat hepatocytes Biotechnol. Bioeng. 40 1286 1295 18601082 10.1002/bit.260401020 1:CAS:528:DyaK3sXksVan
    • (1992) Biotechnol. Bioeng. , vol.40 , pp. 1286-1295
    • Rotem, A.1    Toner, M.2    Tompkins, R.3    Yarmush, M.4
  • 50
    • 0035544007 scopus 로고    scopus 로고
    • Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor
    • DOI 10.1114/1.1415524
    • P Roy H Baskaran AW Tilles ML Yarmush M Toner 2001 Analysis of oxygen transport to hepatocytes in a flat-bed microchannel bioreactor Ann. Biomed. Eng. 29 947 955 11791677 10.1114/1.1415524 1:STN:280:DC%2BD38%2Fmslarsw%3D%3D (Pubitemid 34055196)
    • (2001) Annals of Biomedical Engineering , vol.29 , Issue.11 , pp. 947-955
    • Roy, P.1    Baskaran, H.2    Tilles, A.W.3    Yarmush, M.L.4    Toner, M.5
  • 51
    • 77649262057 scopus 로고    scopus 로고
    • Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels
    • 10.1089/ten.tea.2008.0587 1:CAS:528:DC%2BC3cXis1yns7g%3D
    • TL Sellaro A Ranade DM Faulk GP McCabe K Dorko 2010 Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels Tissue Eng. A 16 1075 1082 10.1089/ten.tea.2008.0587 1:CAS:528:DC%2BC3cXis1yns7g%3D
    • (2010) Tissue Eng. A , vol.16 , pp. 1075-1082
    • Sellaro, T.L.1    Ranade, A.2    Faulk, D.M.3    McCabe, G.P.4    Dorko, K.5
  • 52
    • 77956134221 scopus 로고    scopus 로고
    • Body-on-a chip: Using microfluidic systems to predict human responses to drugs
    • 10.1351/PAC-CON-09-10-44 1:CAS:528:DC%2BC3cXpsFegtL0%3D
    • ML Shuler MB Esch 2010 Body-on-a chip: using microfluidic systems to predict human responses to drugs Pure Appl. Chem. 82 1635 1645 10.1351/PAC-CON-09-10-44 1:CAS:528:DC%2BC3cXpsFegtL0%3D
    • (2010) Pure Appl. Chem. , vol.82 , pp. 1635-1645
    • Shuler, M.L.1    Esch, M.B.2
  • 54
    • 0001559027 scopus 로고
    • Oxygen requirements for liver cells in vitro
    • 5890441 10.1038/206199a0 1:STN:280:DyaF28%2FgvFWisg%3D%3D
    • KM Stevens 1965 Oxygen requirements for liver cells in vitro Nature 206 199 5890441 10.1038/206199a0 1:STN:280:DyaF28%2FgvFWisg%3D%3D
    • (1965) Nature , vol.206 , pp. 199
    • Stevens, K.M.1
  • 55
    • 75749153235 scopus 로고    scopus 로고
    • A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
    • 20126684 10.1039/b917763a 1:CAS:528:DC%2BC3cXhtlGiu7g%3D
    • JH Sung C Kam ML Shuler 2010 A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip Lab Chip 10 446 455 20126684 10.1039/b917763a 1:CAS:528:DC%2BC3cXhtlGiu7g%3D
    • (2010) Lab Chip , vol.10 , pp. 446-455
    • Sung, J.H.1    Kam, C.2    Shuler, M.L.3
  • 56
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
    • 19417905 10.1039/b901377f 1:CAS:528:DC%2BD1MXlsFWju7g%3D
    • JH Sung ML Shuler 2009 A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs Lab Chip 9 1385 1394 19417905 10.1039/b901377f 1:CAS:528:DC%2BD1MXlsFWju7g%3D
    • (2009) Lab Chip , vol.9 , pp. 1385-1394
    • Sung, J.H.1    Shuler, M.L.2
  • 57
    • 33750964743 scopus 로고    scopus 로고
    • Improved hepatocyte excretory function by immediate presentation of polarity cues
    • DOI 10.1089/ten.2006.12.2181
    • NG Susanne R Han S Chang J Ni W Hunziker AB Goryachev H Yu 2006 Improved hepatocyte excretory function by immediate presentation of polarity cues Tissue Eng. 12 2181 2191 10.1089/ten.2006.12.2181 (Pubitemid 44734977)
    • (2006) Tissue Engineering , vol.12 , Issue.8 , pp. 2181-2191
    • Ng, S.1    Han, R.2    Chang, S.3    Ni, J.4    Hunziker, W.5    Goryachev, A.B.6    Ong, S.H.7    Yu, H.8
  • 58
    • 0032431359 scopus 로고    scopus 로고
    • Three-dimensional culture of hepatocytes in a continuously flowing medium
    • K Takeshita WC Bowen GK Michalopoulos 1998 Three-dimensional culture of hepatocytes in a continuously flowing medium In Vitro Cell. Dev. Biol. Anim. 34 482 485 9661052 10.1007/s11626-998-0082-1 1:STN:280:DyaK1czisFCqsQ%3D%3D (Pubitemid 29071773)
    • (1998) Vitro Cellular and Developmental Biology - Animal , vol.34 , Issue.6 , pp. 482-485
    • Takeshita, K.1    Bowen, W.C.2    Michalopoulos, G.K.3
  • 59
    • 33846036487 scopus 로고    scopus 로고
    • Evaluation of effects of shear stress on hepatocytes by a microchip-based system
    • DOI 10.1088/0957-0233/17/12/S08, PII S0957023306202352, S08
    • Y Tanaka M Yamato T Okano T Kitamori K Sato 2006 Evaluation of effects of shear stress on hepatocytes by a microchip-based system Meas. Sci. Technol. 17 3167 3170 10.1088/0957-0233/17/12/S08 1:CAS:528:DC%2BD28XhtlCmsrbP (Pubitemid 46069673)
    • (2006) Measurement Science and Technology , vol.17 , Issue.12 , pp. 3167-3170
    • Tanaka, Y.1    Yamato, M.2    Okano, T.3    Kitamori, T.4    Sato, K.5
  • 60
    • 33644961249 scopus 로고    scopus 로고
    • The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro
    • 16534201 10.1159/000091096
    • RJ Thomas R Bhandari DA Barrett AJ Bennett JR Fry D Powe BJ Thomson KM Shakesheff 2005 The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro Cells Tissues Organs 181 67 79 16534201 10.1159/000091096
    • (2005) Cells Tissues Organs , vol.181 , pp. 67-79
    • Thomas, R.J.1    Bhandari, R.2    Barrett, D.A.3    Bennett, A.J.4    Fry, J.R.5    Powe, D.6    Thomson, B.J.7    Shakesheff, K.M.8
  • 61
    • 0035811241 scopus 로고    scopus 로고
    • Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor
    • DOI 10.1002/bit.1071
    • AW Tilles H Baskaran P Roy ML Yarmush M Toner 2001 Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor Biotechnol. Bioeng. 73 379 389 11320508 10.1002/bit.1071 1:CAS:528:DC%2BD3MXjslWhuro%3D (Pubitemid 32493234)
    • (2001) Biotechnology and Bioengineering , vol.73 , Issue.5 , pp. 379-389
    • Tilles, A.W.1    Baskaran, H.2    Roy, P.3    Yarmush, M.L.4    Toner, M.5
  • 62
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • 19568671 10.1039/b900912d 1:CAS:528:DC%2BD1MXnvVOrt74%3D
    • YC Toh TC Lim D Tai G Xiao D van Noort H Yu 2009 A microfluidic 3D hepatocyte chip for drug toxicity testing Lab Chip 9 2026 2035 19568671 10.1039/b900912d 1:CAS:528:DC%2BD1MXnvVOrt74%3D
    • (2009) Lab Chip , vol.9 , pp. 2026-2035
    • Toh, Y.C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    Van Noort, D.5    Yu, H.6
  • 64
    • 0028136844 scopus 로고
    • Application of spheroid culture to human hepatocytes and maintenance of their differentiation
    • DOI 10.1016/0248-4900(94)90058-2
    • JZ Tong S Sarrazin D Cassio F Gauthier F Alvarez 1994 Application of spheroid culture to human hepatocytes and maintenance of their differentiation Biol. Cell 81 77 81 7987245 10.1016/0248-4900(94)90058-2 1:STN:280: DyaK2M%2FnvVOlsg%3D%3D (Pubitemid 24309448)
    • (1994) Biology of the Cell , vol.81 , Issue.1 , pp. 77-81
    • Tong, J.Z.1    Sarrazin, S.2    Cassio, D.3    Gauthier, F.4    Alvarez, F.5
  • 66
    • 77957671875 scopus 로고    scopus 로고
    • A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
    • 20835427 10.1039/c0lc00043d
    • PM van Midwoud MT Merema E Verpoorte GM Groothuis 2010 A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices Lab Chip 10 2778 2786 20835427 10.1039/c0lc00043d
    • (2010) Lab Chip , vol.10 , pp. 2778-2786
    • Van Midwoud, P.M.1    Merema, M.T.2    Verpoorte, E.3    Groothuis, G.M.4
  • 67
    • 76549134964 scopus 로고    scopus 로고
    • Microfluidic tools for cell biological research
    • 21152269 10.1016/j.nantod.2009.12.001 1:CAS:528:DC%2BC3cXkvFGiur4%3D
    • G Velve-Casquillas M Le Berre M Piel PT Tran 2010 Microfluidic tools for cell biological research Nano Today 5 28 47 21152269 10.1016/j.nantod.2009.12. 001 1:CAS:528:DC%2BC3cXkvFGiur4%3D
    • (2010) Nano Today , vol.5 , pp. 28-47
    • Velve-Casquillas, G.1    Le Berre, M.2    Piel, M.3    Tran, P.T.4
  • 68
    • 33645959303 scopus 로고    scopus 로고
    • Cell-based models to study hepatic drug metabolism and enzyme induction in humans
    • 16922654 10.1517/17425255.1.1.75 1:CAS:528:DC%2BD2MXmvVGhs7o%3D
    • M Vermeir P Annaert R Mamidi D Roymans W Meuldermans G Manners 2005 Cell-based models to study hepatic drug metabolism and enzyme induction in humans Expert Opin. Drug Metab. Toxicol. 1 75 90 16922654 10.1517/17425255.1.1. 75 1:CAS:528:DC%2BD2MXmvVGhs7o%3D
    • (2005) Expert Opin. Drug Metab. Toxicol. , vol.1 , pp. 75-90
    • Vermeir, M.1    Annaert, P.2    Mamidi, R.3    Roymans, D.4    Meuldermans, W.5    Manners, G.6
  • 69
    • 79955489141 scopus 로고    scopus 로고
    • Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes
    • 21259441 10.1002/biot.201000326 1:CAS:528:DC%2BC3MXlsVOhs74%3D
    • B Vinci C Duret S Klieber S Gerbal-Chaloin A Sa-Cunha S Laporte B Suc P Maurel A Ahluwalia M Daujat-Chavanieu 2011 Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes Biotechnol. J. 6 554 564 21259441 10.1002/biot.201000326 1:CAS:528:DC%2BC3MXlsVOhs74%3D
    • (2011) Biotechnol. J. , vol.6 , pp. 554-564
    • Vinci, B.1    Duret, C.2    Klieber, S.3    Gerbal-Chaloin, S.4    Sa-Cunha, A.5    Laporte, S.6    Suc, B.7    Maurel, P.8    Ahluwalia, A.9    Daujat-Chavanieu, M.10
  • 70
    • 1142305959 scopus 로고    scopus 로고
    • Development of a Microscale Cell Culture Analog to Probe Naphthalene Toxicity
    • DOI 10.1021/bp0341996
    • K Viravaidya A Sin ML Shuler 2004 Development of a microscale cell culture analog to probe naphthalene toxicity Biotechnol. Prog. 20 316 323 14763858 10.1021/bp0341996 1:CAS:528:DC%2BD3sXnsFensbw%3D (Pubitemid 38204204)
    • (2004) Biotechnology Progress , vol.20 , Issue.1 , pp. 316-323
    • Viravaidya, K.1    Sin, A.2    Shuler, M.L.3
  • 72
    • 79958779465 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system
    • 21336802 10.1007/s10439-011-0275-8
    • C-R Wan S Chung RD Kamm 2011 Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system Ann. Biomed. Eng. 39 1840 1847 21336802 10.1007/s10439-011-0275-8
    • (2011) Ann. Biomed. Eng. , vol.39 , pp. 1840-1847
    • Wan, C.-R.1    Chung, S.2    Kamm, R.D.3
  • 73
    • 0031452938 scopus 로고    scopus 로고
    • Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation
    • XJ Wang CP Hodgkinson MC Wright AJ Paine 1997 Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation Biochem. J. 328 937 944 9396741 1:CAS:528:DyaK1cXjtVKktw%3D%3D (Pubitemid 28005796)
    • (1997) Biochemical Journal , vol.328 , Issue.3 , pp. 937-944
    • Wang, X.-J.1    Hodgkinson, C.P.2    Wright, M.C.3    Paine, A.J.4
  • 75
    • 0035151025 scopus 로고    scopus 로고
    • Improvement of metabolic performance of cultured hepatocytes by high oxygen tension in the atmosphere
    • DOI 10.1046/j.1525-1594.2001.025001001.x
    • K Yanagi N Ohshima 2001 Improvement of metabolic performance of cultured hepatocytes by high oxygen tension in the atmosphere Artif. Organs 25 1 6 11167552 10.1046/j.1525-1594.2001.025001001.x 1:CAS:528:DC%2BD3MXhtlKntbc%3D (Pubitemid 32113551)
    • (2001) Artificial Organs , vol.25 , Issue.1 , pp. 1-6
    • Yanagi, K.1    Ohshima, N.2
  • 76
    • 34047159398 scopus 로고    scopus 로고
    • Novel Three-Dimensional Organotypic Liver Bioreactor to Directly Visualize Early Events in Metastatic Progression
    • DOI 10.1016/S0065-230X(06)97010-9, PII S0065230X06970109
    • C Yates CR Shepard G Papworth A Dash D Beer Stolz S Tannenbaum L Griffith A Wells 2007 A novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression Adv. Cancer Res. 97 225 232 17419948 10.1016/S0065-230X(06)97010-9 (Pubitemid 46528990)
    • (2007) Advances in Cancer Research , vol.97 , pp. 225-246
    • Yates, C.1    Shepard, C.R.2    Papworth, G.3    Dash, A.4    Beer Stolz, D.5    Tannenbaum, S.6    Griffith, L.7    Wells, A.8
  • 78
    • 33846630926 scopus 로고    scopus 로고
    • Numerical study of mass transfer coefficient in a 3D flat-plate rectangular microchannel bioreactor
    • DOI 10.1016/j.icheatmasstransfer.2006.11.007, PII S073519330600217X
    • Y Zeng T-S Lee P Yu H-T Low 2007 Numerical study of mass transfer coefficient in a 3D flat-plate rectangular microchannel bioreactor Int. Commun. Heat Mass 34 217 224 10.1016/j.icheatmasstransfer.2006.11.007 1:CAS:528:DC%2BD2sXhsVekt7s%3D (Pubitemid 46173175)
    • (2007) International Communications in Heat and Mass Transfer , vol.34 , Issue.2 , pp. 217-224
    • Zeng, Y.1    Lee, T.-S.2    Yu, P.3    Low, H.-T.4
  • 79
    • 79953270125 scopus 로고    scopus 로고
    • Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments
    • 10.1063/1.3553237
    • IK Zervantonakis CR Kothapalli S Chung R Sudo RD Kamm 2011 Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments Biomicrofluidics 5 13406-1 13406-14 10.1063/1.3553237
    • (2011) Biomicrofluidics , vol.5 , pp. 134061-1340614
    • Zervantonakis, I.K.1    Kothapalli, C.R.2    Chung, S.3    Sudo, R.4    Kamm, R.D.5
  • 80
    • 0742305697 scopus 로고    scopus 로고
    • Beyond the Petri dish
    • DOI 10.1038/nbt0204-151
    • S Zhang 2004 Beyond the Petri dish Nat. Biotechnol. 22 151 152 14755282 10.1038/nbt0204-151 1:CAS:528:DC%2BD2cXnvFaqtQ%3D%3D (Pubitemid 38160524)
    • (2004) Nature Biotechnology , vol.22 , Issue.2 , pp. 151-152
    • Zhang, S.1
  • 82
    • 33646703323 scopus 로고    scopus 로고
    • Hepatocyte and Kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function
    • DOI 10.1089/ten.2006.12.751
    • YS Zinchenko LW Schrum M Clemens RN Coger 2006 Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function Tissue Eng. 12 751 761 16674289 10.1089/ten.2006.12.751 1:CAS:528: DC%2BD28Xkt1Kjsbo%3D (Pubitemid 43739282)
    • (2006) Tissue Engineering , vol.12 , Issue.4 , pp. 751-761
    • Zinchenko, Y.S.1    Schrum, L.W.2    Clemens, M.3    Coger, R.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.