Computational fluid model incorporating liver metabolic activities in perfusion bioreactor

Biotechnology and Bioengineering

Volumn 111, Issue 5, 2014, Pages 885-895

  Hsu, Myat Noe ^a   Tan, Guo Dong Sean ^a   Tania, Marshella ^a   Birgersson, Erik ^a   Leo, Hwa Liang ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Hepatotoxicity; HepG2; Metabolic functions; Modeling; Oxygen concentration; Shear stress

Indexed keywords

AMINO ACIDS; BIOCONVERSION; BIOREACTORS; METABOLISM; MODELS; SHEAR STRESS;

COMPUTATIONAL FLUID MODELING; HEPATOCELLULAR CARCINOMA; HEPATOTOXICITY; HEPG2; LIVER-SPECIFIC FUNCTIONS; METABOLIC FUNCTION; OXYGEN CONCENTRATIONS; PHARMACEUTICAL INDUSTRY;

CELL CULTURE;

ALBUMIN; AMMONIA; GLUCOSE; GLUTAMINE; OXYGEN;

AMMONIA FORMATION; ARTICLE; BIOREACTOR; BIOREACTOR DESIGN; CELL CULTURE; FINITE ELEMENT ANALYSIS; FLOW RATE; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION; PERFUSION BIOREACTOR; SHEAR STRESS;

HEPATOTOXICITY; HEPG2; METABOLIC FUNCTIONS; MODELING; OXYGEN CONCENTRATION; SHEAR STRESS;

ALBUMINS; BIOREACTORS; CELL CULTURE TECHNIQUES; CULTURE MEDIA; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; OXYGEN; PERFUSION; STRESS, MECHANICAL;

EID: 84897081417     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25157     Document Type: Article

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