Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments

Biomaterials

Volumn 29, Issue 12, 2008, Pages 1853-1861

  Wong, Amy P ^a,b   Perez Castillejos, Raquel ^b   Christopher Love, J ^c   Whitesides, George M ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Cellular signaling; Co culture; Hydrogel; Macrophage; Microenvironment modeling; Micropatterning

Indexed keywords

CELL CULTURE; LAMINAR FLOW; MACROPHAGES; MICROCHANNELS; MICROFLUIDICS; PROTEINS; ULTRAVIOLET RADIATION;

CELL BIOLOGY; CELLULAR MICROENVIRONMENTS; COLONY-STIMULATING FACTOR; CYTOKINES; SPATIAL DISTRIBUTION;

HYDROGELS;

COLONY STIMULATING FACTOR 1; CYTOKINE; GROWTH FACTOR;

ACCURACY; ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL TYPE; DIFFUSION; HYDROGEL; IMMUNE SYSTEM; IN VITRO STUDY; MACROPHAGE; MICROENVIRONMENT; MICROFLUIDICS; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; TECHNIQUE;

BIOCOMPATIBLE MATERIALS; CELL CULTURE TECHNIQUES; CELL SEPARATION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW CYTOMETRY; HYDROGELS; MICROFLUIDICS; TISSUE ENGINEERING;

EID: 39649115200     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.12.044     Document Type: Article

References (35)

1. Cukierman E., Pankov R., Stevens D.R., and Yamada K.M. Taking cell-matrix adhesions to the third dimension. Science 294 (2001) 1708-1712
2. Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol 13 (2003) 264-269
3. Friedl P., and Brocker E.B. The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci 57 (2000) 41-64
4. McDermott M.F. TNF and TNFR biology in health and disease. Cell Mol Biol 47 (2001) 619-635
5. Singer A.J., and Clark R.A.F. Cutaneous wound healing. N Engl J Med 341 (1999) 738-746
6. Abe M., Zahorchak A.E., Colvin B.L., and Thomson A.W. Migratory responses of murine hepatic myeloid, lymphoid-related, and plasmacytoid dendritic cells to CC chemokines. Transplantation 78 (2004) 762-765
7. Chen C.H., Tsai C.C., Chen W.S., Mi F.L., Liang H.F., Chen S.C., et al. Novel living cell sheet harvest system composed of thermoreversible methylcellulose hydrogels. Biomacromolecules 7 (2006) 736-743
8. Cer E., Gurpinar O.A., Onur M.A., and Tuncel A. Polyethylene glycol-based cationically charged hydrogel beads as a new microcarrier for cell culture. J Biomed Mater Res 80B (2007) 406-414
9. Zaman M.H., Trapani L.M., Siemeski A., MacKellar D., Gong H.Y., Kamm R.D., et al. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci USA 103 (2006) 10889-10894
10. Yu H., Alexander C., and Beebe D.J. Understanding microchannel culture: parameters involved in soluble factor signaling. Lab Chip 7 (2007) 726-730
11. Nelson C.M., and Tien J. Microstructured extracellular matrices in tissue engineering and development. Curr Opin Biotech 17 (2006) 518-523
12. Downing B.R., Cornwell K., Toner M., and Pins G.D. The influence of microtextured basal lamina analog topography on keratinocyte function and epidermal organization. J Biomed Mater Res 72A (2005) 47-56
13. Tan W., and Desai T.A. Layer-by-layer microfluidics for biomimetic three-dimensional structures. Biomaterials 25 (2004) 1355-1364
14. Chen S.-Y., Heilman S., Wasserman M., Archer S., Shuler M., and Wu M. A hydrogel-based microfluidic device for the studies of directed cell migration. Lab Chip 7 (2007) 763-769
15. Karp J.M., Yeo Y., Geng W.L., Cannizarro C., Yan K., Kohane D.S., et al. A photolithographic method to create cellular micropatterns. Biomaterials 27 (2006) 4755-4764
16. Albrecht D.R., Underhill G.H., Wassermann T.B., Sah R.L., and Bhatia S.N. Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods 3 (2006) 369-375
17. Cheung Y.K., Gillette B.M., Zhong M., Ramcharan S., and Sia S.K. Direct patterning of composite biocompatible microstructures using microfluidics. Lab Chip 7 (2007) 574-579
18. Frisk T., Rydholm S., Andersson H., Stemme G., and Brismar H. A concept for miniaturized 3-D cell culture using an extracellular matrix gel. Electrophoresis 26 (2005) 4751-4758
19. Toh Y.-C., Zhang C., Zhang J., Khong Y.M., Chang S., Samper V.D., et al. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip 7 (2007) 302-309
20. Saadi W., Rhee S.W., Lin F., Vahidi B., Chung B.G., and Jeon N.L. Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber. Biomed Microdevices 9 (2007) 627-635
21. Kim M.S., Yeon J.H., and Park J.-K. A microfluidic platform for 3-dimensional cell culture and cell-based assays. Biomed Microdevices 9 (2007) 25-34
22. Xia Y.N., and Whitesides G.M. Soft lithography. Annu Rev Mater Sci 28 (1998) 153-184
23. Sia S.K., and Whitesides G.M. Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 24 (2003) 3563-3576
24. Squires T.M., and Quake S.R. Microfluidics: fluid physics at the nanoliter scale. Rev Mod Phys 77 (2005) 977-1026
25. Stone H.A., Stroock A.D., and Ajdari A. Engineering flows in small devices: microfluidics towards a lab-on-a-chip. Annu Rev Fluid Mech 36 (2004) 381-411
26. Stevens M.M., and George J.H. Exploring and engineering the cell surface interface. Science 310 (2005) 1135-1138
27. Jen A.C., Wake M.C., and Mikos A.G. Hydrogels for cell immobilization. Biotechnol Bioeng 50 (1996) 357-364
28. Krsko P., and Libera M. Biointeractive hydrogels. Mater Today 8 (2005) 36-44
29. Kleinman H.K., and Martin G.R. Matrigel: basement membrane matrix with biological activity. Semin Cancer Biol 15 (2005) 378-386
30. Nerem R.M., Alexander R.W., Chappell D.C., Medford R.M., Varner S.E., and Taylor W.R. The study of the influence of flow on vascular endothelial biology. Am J Med Sci 316 (1998) 169-175
31. Chisti Y. Hydrodynamic damage to animal cells. Crit Rev Biotechnol 21 (2001) 67-110
32. Morgan C., Pollard J.W., and Stanley E.R. Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. J Cell Physiol 130 (1987) 420-427
33. Sklar M.D., Tereba A., Chen B.D.M., and Walker W.S. Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1. J Cell Physiol 125 (1985) 403-412
34. Pixley F.J., and Stanley E.R. CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol 14 (2004) 628-638
35. Yamaguchi H., Wyckoff J., and Condeelis J. Cell migration in tumors. Curr Opin Cell Biol 17 (2005) 559-564