Cereal-Derived Arabinoxylans as Biological Response Modifiers: Extraction, Molecular Features, and Immune-Stimulating Properties

Critical Reviews in Food Science and Nutrition

Volumn 55, Issue 8, 2015, Pages 1035-1052

  Zhang, Shuangyue ^a   LI, Will ^a   Smith, C J ^a   Musa, H ^a  

^a MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

Arabinoxylans; cereal; dietary fibres; immune stimulation; structure

Indexed keywords

IMMUNE SYSTEM; STRUCTURE (COMPOSITION);

ARABINOXYLANS; BIOACTIVE POLYSACCHARIDES; BIOLOGICAL RESPONSE MODIFIERS; CEREAL; DIETARY FIBRE; IMMUNE STIMULATION; IMMUNOMODULATORY EFFECTS; STRUCTURAL HETEROGENEITY;

POLYSACCHARIDES;

ANIMALIA;

ARABINOXYLAN; IMMUNOLOGIC FACTOR; POLYSACCHARIDE; XYLAN;

ANALYSIS; ANIMAL; CEREAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIETARY FIBER; DRUG EFFECTS; HEALTH PROMOTION; HUMAN; IMMUNITY; ISOLATION AND PURIFICATION; ORYZA; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOHYDRATE CONFORMATION; DIETARY FIBER; EDIBLE GRAIN; HEALTH PROMOTION; HUMANS; IMMUNITY; IMMUNOLOGIC FACTORS; MOLECULAR STRUCTURE; ORYZA; POLYSACCHARIDES; STRUCTURE-ACTIVITY RELATIONSHIP; XYLANS;

EID: 84955399728     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2012.705188     Document Type: Article

References (138)

1. Abramson, J., Barbu, E. A. and Pecht, I. (2005). Regulation of mast cell secretory response to the type I Fcepsilon receptor: Inhibitory elements and desensitization. Novartis. Found. Symp. 271:78–89; discussion 89–99.
2. Adams, E. L., Kroon, P. A., Williamson, G., Gilbert, H. J. and Morris, V. J. (2004). Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy. Carbohydr. Res. 339(3):579–590.
3. Agger, J., Johansen, K. S. and Meyer, A. S. (2011). pH catalyzed pretreatment of corn bran for enhanced enzymatic arabinoxylan degradation. New Biotechnol. 28(2):125–135.
4. Alberts, B. (2008) Molecular Biology of the Cell. 5th ed., London: Garland Science.
5. Anderson, J., Baird, P., Jr, D. R., Ferreri, S., Knudtson, M., Koraym, A., Waters, V. and Williams, C. (2009). Health benefits of dietary fiber. Nutr. Rev. 67(4):188–205.
6. Andersson, R., Westerlund, E. and Åman, P. (1994) Natural variations in the contents of structural elements of water-extractable non-starch polysaccharides in white flour. J. Cereal Sci. 19(1):77–82.
7. Badr El-Din, N. K. (2004). Protective role of sanumgerman against γ-irradiation-induced oxidative stress in Ehrlich carcinoma-bearing mice. Nutr. Res. 24(4):271–291.
8. Badr El-Din, N. K., Noaman, E. and Ghoneum, M. (2008). In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr. Cancer. 60(2):235–244.
9. Bang, M., Riep, V., Thinh, N., Song, L., Dung, T., Van Truong, L., Van don, L., Ky, T., Pan, D., Shaheen, M. and Ghoneum, M. (2010). Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 30:5145–5152.
10. Beaugrand, J., Croner, D., Debeire, P. and Chabbert, B. (2004). Arabinoxylan and hydroxycinnamate content of wheat bran in relation to endoxylanase susceptibility. J. Cereal Sci. 40(3):223–230.
11. Bengtsson, S., Åman, P. and Andersson, R. E. (1992). Structural studies on water-soluble arabinoxylans in rye grain using enzymatic hydrolysis. Carbohydr. Polymers. 17(4):277–284.
12. Blank, U. and Rivera, J. (2004). The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol. 25(5):266–273.
13. Blaschek, W., Käsbauer, J., Kraus, J. and Franz, G. (1992). Pythium aphanidermatum: culture, cell-wall composition, and isolation and structure of antitumour storage and solubilised cell-wall (1 → 3),(1 → 6)-β-d-glucans. Carbohydr. Res. 231:293–307.
14. Bohn, J. A. and BeMiller, J. N. (1995) (1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships. Carbohydr. Polymers. 28(1):3–14.
15. Broekaert, W. F., Courtin, C. M., Verbeke, K., Van de Wiele, T., Verstraete, W. and Delcour, J. A. (2011). Prebiotic and other health-related effects of cereal-derived arabinoxylans, arabinoxylan-oligosaccharides, and xylooligosaccharides. Crit. Rev. Food Sci. Nutr. 51(2):178–194.
16. Brown, G. D. and Gordon, S. (2003) Fungal beta-glucans and mammalian immunity. Immunity, 19(3):311–315.
17. Cambi, A., Koopman, M. and Figdor, C. G. (2005). How C-type lectins detect pathogens. Cell. Microbiol. 7(4):481–488.
18. Cao, L., Liu, X. Z., Qian, T. X., Sun, G. B., Guo, Y., Chang, F. J., Zhou, S. M. and Sun, X. B. (2011). Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran. Int. J. Biol. Macromol. 48(1):160–164.
19. Cernadas, M., Lu, J., Watts, G. and Brenner, M. B. (2009). CD1a expression defines an interleukin-12 producing population of human dendritic cells. Clin. Exp. Immunol. 155(3):523–533.
20. Cholujova, D., Jakubikova, J. and Sedlak, J. (2009). BioBran-augmented maturation of human monocyte-derived dendritic cells. Neoplasma. 56(2):89–95.
21. Cleemput, G., Roels, S. P., Vanoort, M., Grobet, P. J. and Delcour, J. A. (1993). Heterogeneity in the structure of water-soluble arabinoxylans in European wheat flours of variable bread-making quality. Cereal Chem. 70(3):324–329.
22. Cravens, P. D. and Lipsky, P. E. (2002). Dendritic cells, chemokine receptors and autoimmune inflammatory diseases. Immunol Cell Biol. 80(5):497–505.
23. Cummings, J. H., Bingham, S. A., Heaton, K. W. and Eastwood, M. A. (1992). Fecal weight, colon cancer risk, and dietary-intake of nonstarch polysaccharides (dietary fiber). Gastroenterology. 103(6):1783–1789.
24. Damen, B., Pollet, A., Dornez, E., Broekaert, W. F., Haesendonck, I. V., Trogh, I., Arnaut, F., Delcour, J. A. and Courtin, C. M. (2012). Xylanase-mediated in situ production of arabinoxylan oligosaccharides with prebiotic potential in whole meal breads and breads enriched with arabinoxylan rich materials. Food Chem. 131(1):111–118.
25. Delcour, J. A., Van Win, H. and Grobet, P. J. (1999). Distribution and structural variation of arabinoxylans in common wheat mill streams. J. Agric. Food Chem. 47(1):271–275.
26. Delcour, J. A., Rouau, X., Courtin, C. M., Poutanen, K. and Ranieri, R. (2012). Technologies for enhanced exploitation of the health-promoting potential of cereals. Trends Food Sci. Technol. 25(2):78–86.
27. Dervilly-Pinel, G., Saulnier, L., Andersson, R. and Aman, P. (2001a). Water-extractable arabinoxylans from pearled flours of wheat, barley, rye and triticale. Evidence for the presence of ferulic acid dimmers and their involvement in gel formation. J. Cereal Sci. 55(2):171–177.
28. Dervilly-Pinel, G., Thibault, J.-F. and Saulnier, L. (2001b) ‘Experimental evidence for a semi-flexible conformation for arabinoxylans’. Carbohydr. Res. 330(3):365–372.
29. Dervilly-Pinel, G., Tran, V. and Saulnier, L. (2004). Investigation of the distribution of arabinose residues on the xylan backbone of water-soluble arabinoxylans from wheat flour. Carbohydr. Polym. 55(2):171–177.
30. Dornez, E., Holopainen, U., Cuyvers, S., Poutanen, J. A., Delcour, J. A., Courtin, C. M. and Nordlund, E. (2011). Study of grain cell wall structures by microscopic analysis with four different staining techniques. J. Cereal Sci. 54(3):363–373.
31. El-Din, N. K. B., Noaman, E. and Ghoneum, M. (2008). In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr. Cancer Int. J. 60(2):235–244.
32. Ellis, M., Egelund, J., Schultz, C. J. and Bacic, A. (2010). Arabinogalactan-proteins: Key regulators at the cell surface? (vol 153, pg 403, 2010). Plant. Physiol. 154(2):1012–1012.
33. Endo, Y. and Kanbayashi, H. (2003). Modified rice bran beneficial for weight loss of mice as a major and acute adverse effect of Cisplatin. Pharmacol. Toxicol. 92(6):300–303.
34. Escarnot, E., Aguedo, M., Agneessens, R., Wathelet, B. and Paquot, M. (2011). Extraction and characterization of water-extractable and water-unextractable arabinoxylans from spelt bran: Study of the hydrolysis conditions for monosaccharides analysis. J. Cereal Sci. 53(1):45–52.
35. Fabre, I., Bruneteau, M., Ricci, P. and Michel, G. (1984). Isolation and structural studies of glucans from Phytophthora parasitica. Eur. J. Biochem./ FEBS, 142(1):99–103.
36. Faulds, C. B., Zanichelli, D., Crepin, V. F., Connerton, I. F., Juge, N., Bhat, M. K. and Waldron, K. W. (2003). Specificity of feruloyl esterases for water-extractable and water-unextractable feruloylated polysaccharides: Influence of xylanase. J. Cereal Sci. 38(3):281–288.
37. Fincher, G. B., Stone, B. A. and Clarke, A. E. (1983). Arabinogalactan-proteins—Structure, biosynthesis, and function. Annu. Rev. Plant Physiol. Plant Mol. Biol. 34:47–70.
38. Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M. and Tsai, M. (2005). Mast cells as “tunable” effector and immunoregulatory cells: Recent advances. Annu. Rev. Immunol. 23:749–786.
39. Ghoneum, M. (1998a). Anti-HIV activity in vitro of MGN-3, an activatedarabinoxylane from rice bran. Biochem. Biophys. Res. Commun. 243(1):25–29.
40. Ghoneum, M. (1998b). Enhancement of human natural killer cell activity by modified arabinoxylan from rice bran (Biobran/MGN-3). Int. J. Immunother. 14(2):89–99.
41. Ghoneum, M. and Abedi, S. (2004). Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J. Pharm. Pharmacol. 56(12):1581–1588.
42. Ghoneum, M. and Brown, J. (1999). NK immunorestoration of cancer patients by biobran/MGN-3, a modified arabinoxylan rice bran (study of 32 patients followed for up to 4 year). Anti Aging Med. Ther. 3:217–226.
43. Ghoneum, M. and Gollapudi, S. (2003). Modified arabinoxylan rice bran (MGN-3/biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett. 201(1):41–49.
44. Ghoneum, M. and Gollapudi, S. (2004). Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 24(3A):1455–1463.
45. Ghoneum, M. and Gollapudi, S. (2005a). Modified arabinoxylan rice bran (MGN-3/biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res. 25(2A):859–870.
46. Ghoneum, M. and Gollapudi, S. (2005b). Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells. Anticancer Res. 25(6B):4187–4196.
47. Ghoneum, M., Hamilton, J. and Gollapudi, S. (2004). Modified arabinoxylan rice bran (MGN-3/biobran), potentiates chemotherapy-induced apoptosis in human breast cancer cells. J. Nutr. 134(12):3521S–3547S.
48. Ghoneum, M. and Jewett, A. (2000). Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro. Cancer Detect. Prev. 24(4):314–324.
49. Ghoneum, M. and Matsuura, M. (2004). Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/Biobran). Int. J. Immunopathol. Pharmacol. 17(3):283–292.
50. Ghoneum, M., Matsuura, M. and Gollapudi, S. (2008a). Modified arabinoxylan rice bran (MGN3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro. Int. J. Immunopathol. Pharmacol. 21(1):87–95.
51. Ghoneum, M., Matsuura, M. and Gollapudi, S. (2008b). Modified arabinoxylan rice bran (MGN-3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro. Int. J. Immunopathol. Pharmacol. 21(1):87–95.
52. Ghoneum, M. and Ogura, T. (1999). Immunomodulation of human NK cell activity by marina crystal minerals (MCM), a crystallized mixture of minerals and trace elements from sea water. Nutr. Res. 19(9):1287–1298.
53. Gollapudi, S. and Ghoneum, M. (2008). MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect. Prev. 32(1):1–6.
54. Gruppen, H., Kormelink, F. J. M. and Voragen, A. G. J. (1993). Water-unextractable cell-wall material from wheat-flour.3. A structural model for arabinoxylans. J. Cereal Sci. 18(2):111–128.
55. Guo, Z., Turner, C. and Castle, D. (1998). Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell, 94(4):537–548.
56. Gupta, M., Mazumder, U. K., Kumar, R. S. and Kumar, T. S. (2004). Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice [corrected]. Acta Pharmacol. Sin. 25(8):1070–1076.
57. Hamuro, J., Maeda, Y., Arai, Y., Fukuoka, F. and Chihara, G. (1971). The significance of the higher structure of the polysaccharides lentinan and pachymaran with regard to their antitumour activity. Chem. Biol. Interact. 3(1):69–71.
58. Harris, N., Peach, R., Naemura, J., Linsley, P. S., Le Gros, G. and Ronchese, F. (1997). CD80 costimulation is essential for the induction of airway eosinophilia. J. Exp. Med. 185(1):177–182.
59. Höije, A., Sandström, C., Roubroeks, J. P., Andersson, R., Gohil, S. and Gatenholm, P. (2006). Evidence of the presence of 2-O-β-d-xylopyranosyl-α-l-arabinofuranose side chains in barley husk arabinoxylan. Carbohydr. Res. 341(18):2959–2966.
60. Hollmann, J. and Lindhauer, M. G. (2005). Pilot-scale isolation of glucuronoarabinoxylans from wheat bran. Carbohydr. Polymers. 59(2):225–230.
61. Hoshino, Y., Hirashima, N., Nakanishi, M. and Furuno, T. (2010). Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice bran. Inflamm. Res. 59(8):615–625.
62. Ito, T., Inaba, M., Inaba, K., Toki, J., Sogo, S., Iguchi, T., Adachi, Y., Yamaguchi, K., Amakawa, R., Valladeau, J., Saeland, S., Fukuhara, S. and Ikehara, S. (1999). A CD1a(+)/CD11c(+) subset of human blood dendritic cells is a direct precursor of Langerhans cells. J. Immunol. 163(3):1409–1419.
63. Izydorczyk, M. S. and Biliaderis, C. G. (1995). Cereal arabinoxylans: Advances in structure and physicochemical properties. Carbohydr. Polymers. 28(1):33–48.
64. Izydorczyk, M. S. and Dexter, J. E. (2008). Barley β-glucans and arabinoxylans: Molecular structure, physicochemical properties, and uses in food products—A Review. Food Res. Int. 41(9):850–868.
65. Izydorczyk, M. S. and MacGregor, A. W. (2000). Evidence of intermolecular interactions of β-glucans and arabinoxylans. Carbohydr. Polym. 41(4):417–420.
66. Izydorczyk, M. S., Macri, L. J. and MacGregor, A. W. (1998a). Structure and physicochemical properties of barley non-starch polysaccharides—I. Water-extractable beta-glucans and arabinoxylans. Carbohydr. Polym. 35(3–4):249–258.
67. Izydorczyk, M. S., Macri, L. J. and MacGregor, A. W. (1998b). Structure and physicochemical properties of barley non-starch polysaccharides—I. Water-extractable β-glucans and arabinoxylans. Carbohydr. Polym. 35(3–4):249–258.
68. Jacoby, H. I., Wnorowski, G., Sakata, K. and Maeda, H. (2000). The effect of MGN-3 on cisplatin and adriamycin induced toxicity in the rat. Gastroenterology. 118(4):A1069–A1069.
69. Jamas, S., Easson, D. D., Ostroff, G. R. and Onderdonk, A. B. (1991). PGG-Glucans. Polymeric Drugs and Drug Delivery Systems, Vol. 469, Washington, DC: American Chemical Society, pp. 44–51.
70. Kiho, T., katsurawaga, M., Nagai, K., Ukai, S. and Haga, M. (1992). Structure and antitumor activity of a branched (1→3)-β-d-glucan from the alkaline extract of Amanita muscaria. Carbohydr. Res. 224(0):237–243.
71. Kiyohara, H., Cyong, J. C. and Yamada, H. (1989). Studies on polysaccharides from angelica-acutiloba. 12. Relationship between structure and activity of the ramified region in anti-complementary pectic polysaccharides from Angelica acutiloba Kitagawa. Carbohydr. Res. 193:201–214.
72. Kojima, H., Nakajima, S., Kamei, K. and Tamesada, M. (2010). Structural analysis of glycogen-like polysaccharides having macrophage-activating activity in extracts of Lentinula edodes mycelia. J. Nat. Med. 64(1):16–23.
73. Lazaridou, A. and Biliaderis, C. G. (2007). Molecular aspects of cereal β-glucan functionality: Physical properties, technological applications and physiological effects. J. Cereal Sci. 46(2):101–118.
74. Liao, H., Chen, Y., Yang, Y., Wang, C. and Chen, Y. (2006). Rice (Oryza sativa L.) inhibits growth and induces differentiation of human leukemic U937 cells through activation of peripheral blood mononuclear cells. Food Chem. Toxicol. 44(10):1724–1729.
75. Liao, H. F., Chou, C. J., Wu, S. H., Khoo, K. H., Chen, C. F. and Wang, S. Y. (2001). Isolation and characterization of an active compound from black soybean [Glycine max (L.) Merr.] and its effect on proliferation and differentiation of human leukemic U937 cells. Anticancer Drugs. 12(10):841–846.
76. Lu, J., Li, Y., Gu, G. X. and Mao, Z. G. (2005). Effects of molecular weight and concentration of arabinoxylans on the membrane plugging. J. Agric. Food Chem. 53(12): 4996–5002.
77. Lu, Z. X., Walker, K. Z., Muir, J. G. and O’Dea, K. (2004). Arabinoxylan fibre improves metabolic control in people with Type II diabetes. Eur J Clin Nutr. 58(4):621–628.
78. Maeda, H., Ichihashi, K., Fujii, T., Omura, K., Zhu, X., Anazawa, M. and Tazawa, K. (2004). Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action. BioFactors. 21(1–4):185–187.
79. Maeda, Y. Y., Watanabe, S. T., Chihara, C. and Rokutanda, M. (1988). Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses. Cancer Res. 48(3):671–675.
80. Maes, C. and Delcour, J. A. (2002). Structural characterisation of water-extractable and water-unextractable arabinoxylans in wheat bran. J. Cereal Sci. 35(3):315–326.
81. Maslen, S. L., Goubet, F., Adam, A., Dupree, P. and Stephens, E. (2007). Structure elucidation of arabinoxylan isomers by normal phase HPLC-MALDI-TOF/TOF-MS/MS. Carbohydr. Res. 342(5):724–735.
82. McCleary, B. V., Prosky, L., Andersson, R. and Aman, P. (2008). Advanced Dietary Fibre Technology. [online] Wiley Blackwell.
83. Misaki, A., Kakuta, M., Sasaki, T., Tanaka, M. and Miyaji, H. (1981). Studies on interrelation of structure and antitumor effects of polysaccharides: Antitumor action of periodate-modified, branched (1 → 3)-β-d-glucan of auricularia auricula-judae, and other polysaccharides containing (1 → 3)-glycosidic linkages. Carbohydr. Res. 92(1):115–129.
84. Mod, R. R., Conkerton, E. J., Ory, R. L. and Normand, F. L. (1978). Hemicellulose composition of dietary fiber of milled rice and rice bran. J. Agric. Food Chem. 26(5):1031–1035.
85. Mod, R. R., Conkerton, E. J., Ory, R. L. and Normand, F. L. (1979). Composition of water-soluble hemicelluloses in rice bran from flour growing areas. Cereal Chem. J. 56(4):356–358.
86. Moers, K., Celus, I., Brijs, K., Courtin, C. M. and Delcour, J. A. (2005). Endoxylanase substrate selectivity determines degradation of wheat water-extractable and water-unextractable arabinoxylan. Carbohydr. Res. 340(7):1319–1327.
87. Muralikrishna, G. and Subba Rao, M. V. S. S. T. (2007). Cereal non-cellulosic polysaccharides: Structure and function relationship—An overview. Crit. Rev. Food Sci. Nutr. 47(6):599–610.
88. Navarro, J., Obrador, E., Carretero, J., Petschen, I., Aviñó, J., Perez, P. and Estrela, J. M. (1999). Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo. Free Radic. Biol. Med. 26(3–4):410–418.
89. Noaman, E., Badr El-Din, N. K., Bibars, M. A., Abou Mossallam, A. A. and Ghoneum, M. (2008a). Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 268(2):348–359.
90. Noaman, E., El-Din, N. K. B., Bibars, M. A., Abou Mossallam, A. A. and Ghoneum, M. (2008b). Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 268(2):348–359.
91. Norisuye, T. (1985). Triple-stranded helical structure of schizophyllan and its antitumor activity in aqueous solution. Die Makromolekulare Chem. 14(S19851):105–118.
92. Ogawa, K., Takeuchi, M. and Nakamura, N. (2005). Immunological effects of partially hydrolyzed arabinoxylan from corn husk in mice. Biosci. Biotechnol. Biochem. 69(1):19–25.
93. Ohno, N., Adachi, Y., Ohsawa, M., Sato, K., Oikawa, S. and Yadomae, T. (1987). Conformational changes of the two different conformers of grifolan in sodium hydroxide, urea or dimethylsulfoxide solution. Chem. Pharm. Bull. 35(5):2108–2113.
94. Ordaz-Ortiz, J. J. and Saulnier, L. (2005). Structural variability of arabinoxylans from wheat flour. Comparison of water-extractable and xylanase-extractable arabinoxylans. J. Cereal Sci. 42(1):119–125.
95. Otterlei, M., Sundan, A., Skjakbraek, G., Ryan, L., Smidsrod, O. and Espevik, T. (1993). Similar mechanisms of action of defined polysaccharides and lipopolysaccharides - characterization of binding and tumor-necrosis-factor-alpha induction. Infect. Immunol. 61(5):1917–1925.
96. Pastell, H., Virkki, L., Harju, E., Tuomainen, P. and Tenkanen, M. (2009). Presence of 1→3-linked 2-O-β-d-xylopyranosyl-α-l-arabinofuranosyl side chains in cereal arabinoxylans. Carbohydr. Res. 344(18):2480–2488.
97. Paumet, F., Le Mao, J., Martin, S., Galli, T., David, B., Blank, U. and Roa, M. (2000). Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: Functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. J. Immunol. 164(11):5850–5857.
98. Pitkanen, L., Tuomainen, P., Virkki, L. and Tenkanen, M. (2011). Molecular characterization and solution properties of enzymatically tailored arabinoxylans. Int. J. Biol. Macromol. 49(5):963–969.
99. Poindexter, N., Sahin, A., Hunt, K. and Grimm, E. (2004). Analysis of dendritic cells in tumor-free and tumor-containing sentinel lymph nodes from patients with breast cancer. Breast Cancer Res. 6(4):R408–R415.
100. Ralet, M. C., Thibault, J. F. and Della Valle, G. (1990). Influence of extrusion-cooking on the physico-chemical properties of wheat bran. J. Cereal Sci. 11(3):249–259.
101. Rao, R. S. P. and Muralikrishna, G. (2004). Non-starch polysaccharide–phenolic acid complexes from native and germinated cereals and millet. Food Chem. 84(4):527–531.
102. Rieder, A., Grimmer, S., Kolset, S. O., Michaelsen, T. E. and Knutsen, S. H. (2011). Cereal β-glucan preparations of different weight average molecular weights induce variable cytokine secretion in human intestinal epithelial cell lines. Food Chem. 128(4):1037–1043.
103. Roubroeks, J. P., Andersson, R. and Åman, P. (2000). Structural features of (1→3),(1→4)-β-d-glucan and arabinoxylan fractions isolated from rye bran. Carbohydr. Polym. 42(1):3–11.
104. Saeed, F., Pasha, I., Anjum, F. M. and Sultan, M. T. (2011). Arabinoxylans and arabinogalactans: A comprehensive treatise. Crit. Rev. Food Sci. Nutr. 51(5):467–476.
105. Samuelsen, A. B., Rieder, A., Grimmer, S., Michaelsen, T. E. and Knutsen, S. H. (2011). Immunomodulatory activity of dietary fiber: Arabinoxylan and mixed-linked beta-glucan isolated from barley show modest activities in vitro. Int. J. Mol. Sci. 12(1):570–587.
106. Sasaki, T. and Takasuka, N. (1976). Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes. Carbohydr. Res. 47(1):99–104.
107. Saulnier, L., Marot, C., Chanliaud, E. and Thibault, J. F. (1995). Cell-wall polysaccharide interactions in maize bran. Carbohydr. Polymers. 26(4):279–287.
108. Saulnier, L., Robert, P., Grintchenko, M., Jamme, F., Bouchet, B. and Guillon, F. (2009). Wheat endosperm cell walls: Spatial heterogeneity of polysaccharide structure and composition using micro-scale enzymatic fingerprinting and FT-IR microspectroscopy. J. Cereal Sci. 50(3):312–317.
109. Saulnier, L., Sado, P.-E., Branlard, G., Charmet, G. and Guillon, F. (2007). Wheat arabinoxylans: Exploiting variation in amount and composition to develop enhanced varieties. J. Cereal Sci. 46(3):261–281.
110. Shibuya, N., Nakane, R., Yasui, A., Tanaka, K. and Iwasaki, T. (1985). Comparative studies on cell-wall preparations from rice bran, germ, and endosperm. Cereal Chem. 62(4):252–258.
111. Smaali, I., Remond, C. and O’Donohue, M. J. (2006). Expression in Escherichia coli and characterization of beta-xylosidases GH39 and GH-43 from Bacillus halodurans C-125. Appl. Microbiol. Biotechnol. 73(3):582–590.
112. Smestad Paulsen, B. (2002). Biologically active polysaccharides as possible lead compounds. Phytochem. Rev. 1(3):379–387.
113. Storsley, J. M., Izydorczyk, M. S., You, S., Biliaderis, C. G. and Rossnagel, B. (2003). Structure and physicochemical properties of β-glucans and arabinoxylans isolated from hull-less barley. Food Hydrocolloids. 17(6):831–844.
114. Stow, J. L., Manderson, A. P. and Murray, R. Z. (2006). SNAREing immunity: The role of SNAREs in the immune system. Nat. Rev. Immunol. 6(12):919–929.
115. Tabata, K., Ito, W., Kojima, T., Kawabata, S. and Misaki, A. (1981). Ultrasonic degradation of schizophyllan, an antitumor polysaccharide produced by Schizophyllum commune Fries. Carbohydr. Res. 89(1):121–135.
116. Takenaka, S. and Itoyama, Y. (1993). Rice bran hemicellulose increases the peripheral blood lymphocytes in rats. Life Sci. 52(1):9–12.
117. Takeshita, M., Nakamura, S., Makita, F., Ohwada, S., Miyamoto, Y. and Morishita, Y. (1992). Antitumor effect of RBS (Rice Bran Saccharide) on Enng-induced carcinogenesis. Biotherapy. 4(2):139–145.
118. Toole, G. A., Le Gall, G., Colquhoun, I. J., Johnson, P., Bedo, Z., Saulnier, L., Shewry, P. R. and Mills, E. N. C. (2011). Spectroscopic analysis of diversity of arabinoxylan structures in endosperm cell walls of wheat cultivars (Triticum aestivum) in the HEALTHGRAIN Diversity Collection. J. Agric. Food Chem. 59(13):7075–7082.
119. Van Rijt, L. S., Vos, N., Willart, M., KleinJan, A., Coyle, A. J., Hoogsteden, H. C. and Lambrecht, B. N. (2004). Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma. J. Allergy Clin. Immunol. 114(1):166–173.
120. Vardakou, M., Katapodis, P., Samiotaki, M., Kekos, D., Panayotou, G. and Christakopoulos, P. (2003). Mode of action of family 10 and 11 endoxylanases on water-unextractable arabinoxylan. Int. J. Biol. Macromol. 33(1–3): 129–134.
121. Van Craeyveld, V., Delcour, J. A. and Courtin, C. M. (2009). Extractability and chemical and enzymic degradation of psyllium (Plantago ovata Forsk) seed husk arabinoxylans. Food Chem. 112(4):812–819.
122. Voet, D. and Voet, J. G. (2004). Biochemistry, Wiley and Sons, Pennsylvania.
123. Volman, J. J., Ramakers, J. D. and Plat, J. (2008). Dietary modulation of immune function by beta-glucans. Physiol. Behav. 94(2):276–284.
124. Wang, L., Zhang, H. B., Zhang, X. Y. and Chen, Z. X. (2008). Purification and identification of a novel heteropolysaccharide RBPS2a with anti-complementary activity from defatted rice bran. Food Chem. 110(1):150–155.
125. Wang, S. Y., Hsu, M. L., Hsu, H. C., Tzeng, C. H., Lee, S. S., Shiao, M. S. and Ho, C. K. (1997). The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int. J. Cancer. 70(6):699–705.
126. Wenger, F. A., Kilian, M., Mautsch, I., Jacobi, C. A., Steiert, A., Peter, F. J., Guski, H., Schimke, I. and Muller, J. M. (2001). Influence of octreotide on liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters. Pancreas. 23(3):266–272.
127. Yamada, H., Kiyohara, H., Cyong, J. C., Kojima, Y., Kumazawa, Y. and Otsuka, Y. (1984). Studies on Polysaccharides from Angelica-Acutiloba. Part 1. Fractionation and Biological Properties of Polysaccharides. Planta Med. 50(2):163–167.
128. Yamada, H., Kiyohara, H., Cyong, J. C. and Otsuka, Y. (1985). Studies on Polysaccharides from Angelica-Acutiloba. Part 4. Characterization of an Anti-Complementary Arabinogalactan from the Roots of Angelica-Acutiloba Kitagawa. Mol. Immunol. 22(3):295–304.
129. Yamada, H., Komiyama, K., Kiyohara, H., Cyong, J. C., Hirakawa, Y. and Otsuka, Y. (1990). Studies on polysaccharides from Angelica-Acutiloba. Part 13. Structural characterization and antitumor-activity of a pectic polysaccharide from the roots of Angelica-Acutiloba. Planta Med. 56(2):182–186.
130. Yamagishi, T., Matsuda, K. and Watanabe, T. (1975). Isolation and partial characterization of proteoglycans from rice bran. Carbohydr. Res. 43(2):321–333.
131. Yamagishi, T., Matsuda, K. and Watanabe, T. (1976). Characterization of the fragments obtained by enzymic and alkaline degradation of rice-bran proteoglycans. Carbohydr. Res. 50(1):63–74.
132. Yamagishi, T., Tsuboi, T. and Kikuchi, K. (2003). Potent natural immunomodulator, rice water-soluble polysaccharide fractions with anticomplementary activity1. Cereal Chem. J. 80(1):5–8.
133. Yamagishi, T., Yamaguchi, A., Saito, T. and Seguchi, M. (2008). Complement-modulating water-soluble polysaccharide fractions in two global staple cereals: Rice and wheat. J. Sci. Food Agric. 88(5):805–812.
134. Yui, T., Imada, K., Shibuya, N. and Ogawa, K. (1995). Conformation of an arabinoxylan isolated from the rice endosperm cell wall by x-ray diffraction and a conformational analysis. Biosci. Biotechnol. Biochem. 59(6):965–968.
135. Zhang, P., Zhang, Q. and Whistler, R. L. (2003). l-arabinose release from arabinoxylan and arabinogalactan under potential gastric acidities. Cereal Chem. J. 80(3):252–254.
136. Zhang, P. Y., Wampler, J. L., Bhunia, A. K., Burkholder, K. M., Patterson, J. A. and Whistler, R. L. (2004). Effects of arabinoxylans on activation of murine macrophages and growth performance of broiler chicks. Cereal Chem. 81(4):511–514.
137. Zhou, L. J. and Tedder, T. F. (1996). CD14(+) blood monocytes can differentiate into functionally mature CD83(+) dendritic cells. Proc. Natl. Acad. Sci. USA. 93(6):2588–2592.
138. Zhou, S., Liu, X., Guo, Y., Wang, Q., Peng, D. and Cao, L. (2010). Comparison of the immunological activities of arabinoxylans from wheat bran with alkali and xylanase-aided extraction. Carbohydr. Polym. 81(4):784–789.