Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle

Journal of the National Cancer Institute

Volumn 106, Issue 7, 2014, Pages

  Noreen, Faiza ^a   Röösli, Martin ^b   Gaj, Pawel ^c   Pietrzak, Jakub ^c   Weis, Stefan ^a   Urfer, Patric ^a   Regula, Jaroslaw ^c   Schär, Primo ^a   Truninger, Kaspar ^a,d  

^a UNIVERSITY OF BASEL   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c INSTITUTE OF ONCOLOGY   (Poland)

^d FMH Gastroenterology and Internal Medicine   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID;

ADULT; AGED; ARTICLE; BODY MASS; CANCER RISK; CELL AGING; COLON BIOPSY; COLON MUCOSA; COLON POLYP; COLORECTAL CANCER; CPG ISLAND; DNA METHYLATION; FEMALE; GENOME ANALYSIS; HORMONE SUBSTITUTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIFESTYLE; MAJOR CLINICAL STUDY; MIDDLE AGED; PRIORITY JOURNAL; PROMOTER REGION; SMOKING; VERY ELDERLY;

AGE FACTORS; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; COHORT STUDIES; COLON; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; EARLY DETECTION OF CANCER; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LIFE STYLE; MASS SCREENING; MIDDLE AGED; PROMOTER REGIONS, GENETIC;

EID: 84905238318     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/dju161     Document Type: Article

References (41)

1. You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell. 2012;22(1):9-20.
2. De Carvalho DD, Sharma S, You JS, et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 2012;21(5):655-667.
3. Sandoval J, Esteller M. Cancer epigenomics: beyond genomics. Curr Opin Genet Dev. 2012;22(1):50-55.
4. Baylin SB, Jones PA. A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer. 2011;11(10):726-734.
5. Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med. 2009;361(15):1475-1485.
6. Balducci L, Ershler WB. Cancer and ageing: A nexus at several levels. Nat Rev Cancer. 2005;5(8):655-662.
7. Belshaw NJ, Pal N, Tapp HS, et al. Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. Carcinogenesis. 2010;31(6):1158-1163.
8. Teschendorff AE, Menon U, Gentry-Maharaj A, et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res. 2010;20(4):440-446.
9. Bell JT, Tsai PC, Yang TP, et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet. 2012;8(4):e1002629.
10. Landan G, Cohen NM, Mukamel Z, et al. Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nat Genet. 2012;44(11):1207-1214.
11. Menigatti M, Truninger K, Gebbers JO, et al. Normal colorectal mucosa exhibits sex-and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene. 2009;28(6):899-909.
12. Wallace K, Grau MV, Levine AJ, et al. Association between folate levels and CpG island hypermethylation in normal colorectal mucosa. Cancer Prev Res. 2010;3(12):1552-1564.
13. Tapp HS, Commane DM, Bradburn DM, et al. Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell. 2013;12(1):148-155.
14. Horii J, Hiraoka S, Kato J, et al. Age-related methylation in normal colon mucosa differs between the proximal and distal colon in patients who underwent colonoscopy. Clin Biochem. 2008;41(18):1440-1448.
15. Chan AT, Ogino S, Fuchs CS. aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med. 2007;356(21):2131-2142.
16. Long MD, Martin CF, Galanko JA, et al. Hormone replacement therapy, oral contraceptive use, and distal large bowel cancer: A population-based case-control study. Am J Gastroenterol. 2010;105(8):1843-1850.
17. Robsahm TE, Aagnes B, Hjartaker A, et al. Body mass index, physical activity, and colorectal cancer by anatomical subsites: A systematic review and meta-analysis of cohort studies. Eur J Cancer Prev. 2013;22(6):492-505.
18. Parajuli R, Bjerkaas E, Tverdal A, et al. The increased risk of colon cancer due to cigarette smoking may be greater in women than men. Cancer Epidem Biomar. 2013;22(5):862-871.
19. Sandler RS, Halabi S, Baron JA, et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 2003;348(10):883-890.
20. Regula J, Rupinski M, Kraszewska E, et al. Colonoscopy in colorectalcancer screening for detection of advanced neoplasia. N Engl J Med. 2006;355(18):1863-1872.
21. Hinoue T, Weisenberger DJ, Lange CP, et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 2012;22(2):271-282.
22. Sabates-Bellver J, Van der Flier LG, de Palo M, et al. Transcriptome profile of human colorectal adenomas. Mol Cancer Res. 2007;5(12):1263-1275.
23. Watson CT, Disanto G, Sandve GK, et al. Age-associated hyper-methylated regions in the human brain overlap with bivalent chromatin domains. Plos One. 2012;7(9):e43840.
24. Rakyan VK, Down TA, Maslau S, et al. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res. 2010;20(4):434-439.
25. Ku M, Koche RP, Rheinbay E, et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 2008;4(10):e1000242.
26. Du P, Zhang X, Huang CC, et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 2010;11:587.
27. Chen JS, Hung WS, Chan HH, et al. In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 2013;29(4):420-427.
28. Richter AM, Pfeifer GP, Dammann RH. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Bba-Rev Cancer. 2009;1796(2):114-128.
29. Gonzalo V, Lozano JJ, Munoz J, et al. Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. Plos One. 2010;5(1):e8777.
30. Pehlivan S, Artac M, Sever T, et al. Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. Cancer Genet Cytogen. 2010;201(2):128-132.
31. Koch CM, Suschek CV, Lin Q, et al. Specific age-associated DNA methylation changes in human dermal fibroblasts. Plos One. 2011;6(2):e16679.
32. Alisch RS, Barwick BG, Chopra P, et al. Age-associated DNA methylation in pediatric populations. Genome Res. 2012;22(4):623-632.
33. Bosetti C, Rosato V, Gallus S, et al. aspirin and cancer risk: A quantitative review to 2011. Ann Oncol. 2012;23(6):1403-1415.
34. Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 2012;13(5):518-527.
35. Maxwell PH. Tumor strengths and frailties: Aspiring to prevent colon cancer. Nat Med. 2012;18(1):32-33.
36. Thun MJ, Jacobs EJ, Patrono C. The role of aspirin in cancer prevention. Nat Rev Clin Oncol. 2012;9(5):259-267.
37. Liao XY, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. New Engl J Med. 2012;367(17):1596-1606.
38. West J, Beck S, Wang X, et al. An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways. Sci Rep. 2013;3:1630.
39. Maegawa S, Hinkal G, Kim HS, et al. Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res. 2010;20(3):332-340.
40. Teschendorff AE, Menon U, Gentry-Maharaj A, et al. An epigenetic signature in peripheral blood predicts active ovarian cancer. Plos One. 2009;4(12):e8274.
41. Estecio MR, Issa JP. Dissecting DNA hypermethylation in cancer. FEBS Lett. 2011;585(13):2078-2086