Parental ages and levels of DNA methylation in the newborn are correlated

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Adkins, Ronald M ^a   Thomas, Fridtjof ^a   Tylavsky, Frances A ^a   Krushkal, Julia ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CPG DINUCLEOTIDE; DINUCLEOTIDE; DNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CHROMOSOME REARRANGEMENT; DNA METHYLATION; FEMALE; GENETIC ASSOCIATION; GLUCOSE METABOLISM; HUMAN; MALE; NEWBORN; PARENTAL AGE; SEX DIFFERENCE; X CHROMOSOME; AGING; CPG ISLAND; FETUS BLOOD; GENETIC PREDISPOSITION; GENETICS; MATERNAL AGE; METABOLISM; PARENT; PATERNAL AGE;

ADULT; AGING; CPG ISLANDS; DNA METHYLATION; FEMALE; FETAL BLOOD; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT, NEWBORN; MALE; MATERNAL AGE; PARENTS; PATERNAL AGE;

EID: 79953180072     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-47     Document Type: Article

References (52)

1. Eckhardt F, Lewin J, Cortese R, Rakyan VK, Attwood J, Burger M, Burton J, Cox TV, Davies R, Down TA, Haefliger C, Horton R, Howe K, Jackson DK, Kunde J, Koenig C, Liddle J, Niblett D, Otto T, Pettett R, Seemann S, Thompson C, West T, Rogers J, Olek A, Berlin K, Beck S. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet 2006, 38(12):1378-1385. 10.1038/ng1909, 17072317.
2. Rakyan VK, Hildmann T, Novik KL, Lewin J, Tost J, Cox AV, Andrews TD, Howe KL, Otto T, Olek A, Fischer J, Gut IG, Berlin K, Beck S. DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol 2004, 2(12):e405. 10.1371/journal.pbio.0020405, 529316, 15550986.
3. Song F, Smith JF, Kimura MT, Morrow AD, Matsuyama T, Nagase H, Held WA. Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc Natl Acad Sci USA 2005, 102(9):3336-3341. 10.1073/pnas.0408436102, 552919, 15728362.
4. Weaver JR, Susiarjo M, Bartolomei MS. Imprinting and epigenetic changes in the early embryo. Mamm Genome 2009, 20(9-10):532-543. 10.1007/s00335-009-9225-2, 19760320.
5. Wilson AS, Power BE, Molloy PL. DNA hypomethylation and human diseases. Biochim Biophys Acta 2007, 1775(1):138-162.
6. Gravina S, Vijg J. Epigenetic factors in aging and longevity. Pflugers Arch 2010, 459(2):247-258. 10.1007/s00424-009-0730-7, 19768466.
7. Fuke C, Shimabukuro M, Petronis A, Sugimoto J, Oda T, Miura K, Miyazaki T, Ogura C, Okazaki Y, Jinno Y. Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study. Ann Hum Genet 2004, 68(Pt 3):196-204. 10.1046/j.1529-8817.2004.00081.x, 15180700.
8. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005, 102(30):10604-10609. 10.1073/pnas.0500398102, 1174919, 16009939.
9. Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 2009, 5(8):e1000602. 10.1371/journal.pgen.1000602, 2718614, 19680444.
10. Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, Kahn RS, Ophoff RA. The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One 2009, 4(8):e6767. 10.1371/journal.pone.0006767, 2747671, 19774229.
11. Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, Beyan H, Whittaker P, McCann OT, Finer S, Valdes AM, Leslie RD, Deloukas P, Spector TD. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res 2010, 20(4):434-439. 10.1101/gr.103101.109, 2847746, 20219945.
12. Liu J, Morgan M, Hutchison K, Calhoun VD. A study of the influence of sex on genome wide methylation. PLoS One 2010, 5(4):e10028. 10.1371/journal.pone.0010028, 2850313, 20386599.
13. Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, Savage DA, Mueller-Holzner E, Marth C, Kocjan G, Gayther SA, Jones A, Beck S, Wagner W, Laird PW, Jacobs IJ, Widschwendter M. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 2010, 20(4):440-446. 10.1101/gr.103606.109, 2847747, 20219944.
14. Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, Sparrow D, Vokonas P, Baccarelli A. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009, 130(4):234-239. 10.1016/j.mad.2008.12.003, 2956267, 19150625.
15. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, Yu W, Rongione MA, Ekstrom TJ, Harris TB, Launer LJ, Eiriksdottir G, Leppert MF, Sapienza C, Gudnason V, Feinberg AP. Intra-individual change over time in DNA methylation with familial clustering. JAMA 2008, 299(24):2877-2883. 10.1001/jama.299.24.2877, 2581898, 18577732.
16. Sartorius GA, Nieschlag E. Paternal age and reproduction. Hum Reprod Update 2010, 16(1):65-79. 10.1093/humupd/dmp027, 19696093.
17. Cardwell CR, Carson DJ, Patterson CC. Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study. Diabet Med 2005, 22(2):200-206. 10.1111/j.1464-5491.2005.01369.x, 15660739.
18. King MD, Fountain C, Dakhlallah D, Bearman PS. Estimated autism risk and older reproductive age. Am J Public Health 2009, 99(9):1673-1679. 10.2105/AJPH.2008.149021, 2724463, 19608957.
19. Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, Gunnell D. Paternal age and schizophrenia: a population based cohort study. BMJ 2004, 329(7474):1070. 10.1136/bmj.38243.672396.55, 526116, 15501901.
20. Menezes PR, Lewis G, Rasmussen F, Zammit S, Sipos A, Harrison GL, Tynelius P, Gunnell D. Paternal and maternal ages at conception and risk of bipolar affective disorder in their offspring. Psychol Med 2010, 40(3):477-485. 10.1017/S003329170999064X, 19627644.
21. Comings DE, MacMurray JP. Maternal age at the birth of the first child as an epistatic factor in polygenic disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2006, 141B(1):1-6.
22. Lu Y, Ma H, Sullivan-Halley J, Henderson KD, Chang ET, Clarke CA, Neuhausen SL, West DW, Bernstein L, Wang SS. Parents' Ages at Birth and Risk of Adult-onset Hematologic Malignancies Among Female Teachers in California. Am J Epidemiol 2010, 171(12):1262-1269. 10.1093/aje/kwq090, 20507900.
23. Johnson KJ, Carozza SE, Chow EJ, Fox EE, Horel S, McLaughlin CC, Mueller BA, Puumala SE, Reynolds P, Von Behren J, Spector LG. Parental age and risk of childhood cancer: a pooled analysis. Epidemiology 2009, 20(4):475-483. 10.1097/EDE.0b013e3181a5a332, 2738598, 19373093.
24. Podvin D, Kuehn CM, Mueller BA, Williams M. Maternal and birth characteristics in relation to childhood leukaemia. Paediatr Perinat Epidemiol 2006, 20(4):312-322. 10.1111/j.1365-3016.2006.00731.x, 16879503.
25. Maule MM, Vizzini L, Merletti F, Magnani C, Pastore G, Richiardi L. Parental age and risk of acute lymphocytic leukaemia and embryonal tumours in the Piedmont Region, Italy. Int J Epidemiol 2007, 36(3):691-692. 10.1093/ije/dym115, 17550942.
26. Maule MM, Merletti F, Pastore G, Magnani C, Richiardi L. Effects of maternal age and cohort of birth on incidence time trends of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 2007, 16(2):347-351. 10.1158/1055-9965.EPI-06-0425, 17301270.
27. Yip BH, Pawitan Y, Czene K. Parental age and risk of childhood cancers: a population-based cohort study from Sweden. Int J Epidemiol 2006, 35(6):1495-1503. 10.1093/ije/dyl177, 17008361.
28. Hemminki K, Kyyronen P, Vaittinen P. Parental age as a risk factor of childhood leukemia and brain cancer in offspring. Epidemiology 1999, 10(3):271-275. 10.1097/00001648-199905000-00014, 10230837.
29. Moll AC, Imhof SM, Kuik DJ, Bouter LM, Den Otter W, Bezemer PD, Koten JW, Tan KE. High parental age is associated with sporadic hereditary retinoblastoma: the Dutch retinoblastoma register 1862-1994. Hum Genet 1996, 98(1):109-112. 10.1007/s004390050168, 8682494.
30. Hodgson ME, Newman B, Millikan RC. Birthweight, parental age, birth order and breast cancer risk in African-American and white women: a population-based case-control study. Breast Cancer Res 2004, 6(6):R656-667. 10.1186/bcr931, 1064078, 15535848.
31. Zhang Y, Kreger BE, Dorgan JF, Cupples LA, Myers RH, Splansky GL, Schatzkin A, Ellison RC. Parental age at child's birth and son's risk of prostate cancer. The Framingham Study. Am J Epidemiol 1999, 150(11):1208-1212.
32. Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 2006, 114(4):567-572. 10.1289/ehp.8700, 1440782, 16581547.
33. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002, 3(9):662-673. 10.1038/nrg887, 12209141.
34. Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001, 293(5532):1089-1093. 10.1126/science.1063443, 11498579.
35. Cotton AM, Avila L, Penaherrera MS, Affleck JG, Robinson WP, Brown CJ. Inactive X chromosome-specific reduction in placental DNA methylation. Hum Mol Genet 2009, 18(19):3544-3552. 10.1093/hmg/ddp299, 2742397, 19586922.
36. Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 2008, 147B(5):543-549. 10.1002/ajmg.b.30657, 17987668.
37. Adkins RM, Krushkal J, Tylavsky F, Thomas F. Racial Differences in Gene-Specific DNA Methylation Levels are Present at Birth. Birth Defects Res A Clin Mol Teratol 2011,
38. Palmer C, Diehn M, Alizadeh AA, Brown PO. Cell-type specific gene expression profiles of leukocytes in human peripheral blood. BMC Genomics 2006, 7:115. 10.1186/1471-2164-7-115, 1479811, 16704732.
39. Online Mendelian Inheritance in Man. , http://www.ncbi.nlm.nih.gov/omim/
40. Database for Annotation, Visualization and Integrated Discovery (DAVID). , http://david.abcc.ncifcrf.gov/
41. Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003, 4(5):P3. 10.1186/gb-2003-4-5-p3, 12734009.
42. Tucker KL, Beard C, Dausmann J, Jackson-Grusby L, Laird PW, Lei H, Li E, Jaenisch R. Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev 1996, 10(8):1008-1020. 10.1101/gad.10.8.1008, 8608936.
43. Borgel J, Guibert S, Li Y, Chiba H, Schubeler D, Sasaki H, Forne T, Weber M. Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet 2010, 42(12):1093-1100. 10.1038/ng.708, 21057502.
44. Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Powe NR, Feinberg AP. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 2003, 299(5613):1753-1755. 10.1126/science.1080902, 12637750.
45. Ally MS, Al-Ghnaniem R, Pufulete M. The relationship between gene-specific DNA methylation in leukocytes and normal colorectal mucosa in subjects with and without colorectal tumors. Cancer Epidemiol Biomarkers Prev 2009, 18(3):922-928. 10.1158/1055-9965.EPI-08-0703, 19258481.
46. Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, Yang AS. Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet 2009, 18(24):4808-4817. 10.1093/hmg/ddp445, 19776032.
47. Talens RP, Boomsma DI, Tobi EW, Kremer D, Jukema JW, Willemsen G, Putter H, Slagboom PE, Heijmans BT. Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J 2010, 24(9):3135-3144. 10.1096/fj.09-150490, 20385621.
48. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4(1):44-57. 10.1038/nprot.2008.211, 19131956.
49. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003, 100(16):9440-9445. 10.1073/pnas.1530509100, 170937, 12883005.
50. QVALUE software. , http://www.genomine.org/qvalue/
51. Morison IM, Paton CJ, Cleverley SD. The imprinted gene and parent-of-origin effect database. Nucleic Acids Res 2001, 29(1):275-276. 10.1093/nar/29.1.275, 29803, 11125110.
52. Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Gayther SA, Apostolidou S, Jones A, Lechner M, Beck S, Jacobs IJ, Widschwendter M. An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One 2009, 4(12):e8274. 10.1371/journal.pone.0008274, 2793425, 20019873.