Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol)

Molecular Pharmaceutics

Volumn 13, Issue 1, 2016, Pages 134-143

  Liu, Li ^a,b   Zheng, Mengyao ^a   Librizzi, Damiano ^c   Renette, Thomas ^a   Merkel, Olivia M ^a,d   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c UNIVERSITY HOSPITAL MARBURG   (Germany)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

folate targeting; prolonged circulation; siRNA delivery; SKOV 3 tumor xenograft; SPECT imaging; tumor targeting

Indexed keywords

COPOLYMER; FOLATE RECEPTOR; FOLIC ACID; MACROGOL; NANOCARRIER; POLYCAPROLACTONE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; IMINE; MACROGOL DERIVATIVE; POLY(ETHYLENE GLYCOL)-FOLATE; POLY(ETHYLENE IMINE); POLYESTER; POLYETHYLENE DERIVATIVE; POLYETHYLENIMINE-GRAFT-POLYCAPROLACTONE-BLOCK-POLY(ETHYLENE GLYCOL); POLYMER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONJUGATION; ENDOCYTOSIS; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MICELLE; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; SYNTHESIS; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; FEMALE; GENE TRANSFER; MOUSE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FEMALE; FOLIC ACID; GENE TRANSFER TECHNIQUES; HUMANS; IMINES; MICE; MICE, INBRED BALB C; POLYESTERS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYETHYLENES; POLYMERS; RNA, SMALL INTERFERING;

EID: 84953439973     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00575     Document Type: Article

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