Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density

International Journal of Pharmaceutics

Volumn 427, Issue 1, 2012, Pages 80-87

  Zheng, Mengyao ^a   Liu, Yu ^a   Samsonova, Olga ^a   Endres, Thomas ^a   Merkel, Olivia ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Biodegradable copolymer; Buffer capacity; Graft density; Hyper branched poly(ethylene imine) (hyPEI); Non viral gene delivery; Transfection

Indexed keywords

AMPHOPHILE; BUFFER; COPOLYMER; HYPER BRANCHED POLY(ETHYLENEIMINE G CAPROLACTONE B ETHYLENE GLYCOL); PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIODEGRADABILITY; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DENSITY; DNA TRANSFECTION; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; GENE EXPRESSION; GENE VECTOR; HUMAN; HUMAN CELL; MOLECULAR STABILITY; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TRANSGENE; ZETA POTENTIAL;

CELL LINE, TUMOR; DRUG CARRIERS; ETHYLENE GLYCOLS; GENE EXPRESSION; HUMANS; INHIBITORY CONCENTRATION 50; MICROSCOPY, CONFOCAL; PARTICLE SIZE; PLASMIDS; POLYESTERS; POLYETHYLENEIMINE; TRANSFECTION; TRANSGENES;

EID: 84858753764     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.017     Document Type: Article

References (35)

1. M.G. Banaszczyk Poly-l-lysine-Graft-Peg comb-type polycation copolymers for gene delivery J. Macromol. Sci. A: Pure Appl. Chem. 36 1999 1061 1084 (Pubitemid 129613825)
2. J.-P. Behr The proton sponge: a trick to enter cells the viruses did not exploit CHIMIA Int. J. Chem. 51 1997 34 36 (Pubitemid 127033737)
3. A.U. Bielinska The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA Biochim. Biophys. Acta 1353 1997 180 190 (Pubitemid 27360174)
4. O. Boussif A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U.S.A. 92 1995 7297 7301
5. E. Check A tragic setback Nature 420 2002 116 118 (Pubitemid 35340095)
6. G. Creusat Proton sponge trick for pH-sensitive disassembly of polyethylenimine-based siRNA delivery systems Bioconjug. Chem. 21 2010 994 1002
7. D. Fischer A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity Pharm. Res. 16 1999 1273 1279 (Pubitemid 29393618)
8. D. Fischer In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 24 2003 1121 1131 (Pubitemid 36069121)
9. R.I. Freshney Culture of Animal Cells: A Manual of Basic Technique 5th ed. 2005 Wiley-Liss Wilmington, DE
10. W.T. Godbey Poly(ethylenimine) and its role in gene delivery J. Control. Release 60 1999 149 160 (Pubitemid 29335941)
11. S. Hacein-Bey-Abina LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 Science 302 2003 415 419 (Pubitemid 37296260)
12. S. Han Water-soluble lipopolymer for gene delivery Bioconjug. Chem. 12 2001 337 345 (Pubitemid 32464179)
13. S. Han Development of biomaterials for gene therapy Mol. Ther. 2 2000 302 317
14. Y.C. Jong Investigation of DNA spectral conformational changes and polymer buffering capacity in relation to transfection efficiency of DNA/polymer complexes J. Pharm. Pharm. Sci. 12 2009 346 356
15. K. Kono Transfection activity of polyamidoamine dendrimers having hydrophobic amino acid residues in the periphery Bioconjug. Chem. 16 2005 208 214 (Pubitemid 40129695)
16. K. Kunath Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine J. Control. Release 89 2003 113 125 (Pubitemid 36412116)
17. Y. Liu A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors Polymer 50 2009 3895 3904
18. Y. Liu Degradation of Hyper-Branched Poly(Ethylenimine)-Graft- Poly(Caprolactone)-Block-Monomethoxyl-Poly(Ethylene Glycol) as a Potential Gene Delivery Vector 2010 Wiley-VCH Verlag pp. 1509-1515
19. H. Luthman, and G. Magnusson High efficiency polyoma DNA transfection of chloroquine treated cells Nucleic Acids Res. 11 1983 1295 1308
20. E. Marshall BIOMEDICINE: gene therapy on trial Science 288 2000 951 957
21. T. Merdan Prospects for cationic polymers in gene and oligonucleotide therapy against cancer Adv. Drug Deliv. Rev. 54 2002 715 758 (Pubitemid 35247524)
22. I. Moret Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum J. Control. Release 76 2001 169 181 (Pubitemid 32786894)
23. D.W. Pack Design and development of polymers for gene delivery Nat. Rev. Drug Discov. 4 2005 581 593 (Pubitemid 40975711)
24. M.R. Park Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers J. Control. Release 105 2005 367 380
25. R. Pawliuk Correction of sickle cell disease in transgenic mouse models by gene therapy Science 294 2001 2368 2371 (Pubitemid 33140563)
26. H. Petersen Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system Bioconjug. Chem. 13 2002 845 854 (Pubitemid 34801128)
27. S.H. Pun Cyclodextrin-modified polyethylenimine polymers for gene delivery Bioconjug. Chem. 15 2004 831 840 (Pubitemid 38981958)
28. D.V. Schaffer Vector Unpacking as a Potential Barrier for Receptor-Mediated Polyplex Gene Delivery 2000 John Wiley & Sons, Inc. pp. 598-606
29. X. Shuai Novel biodegradable ternary copolymers hy-PEI-g-PCL-b-PEG: synthesis, characterization, and potential as efficient nonviral gene delivery vectors Macromolecules 36 2003 5751 5759
30. S.-J. Sung Effect of polyethylene glycol on gene delivery of polyethylenimine Biol. Pharm. Bull. 26 2003 492 500 (Pubitemid 39663595)
31. H. Tian Gene transfection of hyperbranched PEI grafted by hydrophobic amino acid segment PBLG Biomaterials 28 2007 2899 2907 (Pubitemid 46482665)
32. D. von Laer Gene therapy for HIV infection: what does it need to make it work? J. Gene Med. 8 2006 658 667
33. D.-a. Wang Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery Biomacromolecules 3 2002 1197 1207 (Pubitemid 35423019)
34. L.F. Wong Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications Hum. Gene Ther. 17 2006 1 9
35. S.Y. Wong Polymer systems for gene delivery - past, present, and future Prog. Polym. Sci. 32 2007 799 837 (Pubitemid 47198291)