NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Tan, Chen Chen ^a   Zhang, Jian Guo ^b,c   Tan, Meng Shan ^d   Chen, Hua ^a   Meng, Da Wei ^b,c   Jiang, Teng ^e   Meng, Xiang Fei ^a   Li, Ying ^a   Sun, Zhen ^a   Li, Meng Meng ^a   Yu, Jin Tai ^a,d,e,f   Tan, Lan ^a,d,e  

^a QINGDAO UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d OCEAN UNIVERSITY OF CHINA   (China)

^e NANJING MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caspase 1; inflammasome; NLRP1; pyroptosis; temporal lobe epilepsy

Indexed keywords

CASPASE; INFLAMMASOME; INTERLEUKIN 1BETA; PROTEIN NLRP1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; ENOLASE; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; AMYGDALOID NUCLEUS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BENIGN TUMOR; BRAIN TUMOR; CAUSE OF DEATH; CELL DEATH; CONTROLLED STUDY; DISEASE DURATION; ELECTRODE; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPTIC FOCUS; FEMALE; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KINDLING; MALE; MEDIAL TEMPORAL LOBE; MESIAL TEMPORAL LOBE EPILEPSY; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYROPTOSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEIZURE; TEMPORAL LOBE EPILEPSY; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; ADVERSE EFFECTS; AMYGDALA; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ELECTROSTIMULATION; EPILEPSY, TEMPORAL LOBE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; YOUNG ADULT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AMYGDALA; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EPILEPSY, TEMPORAL LOBE; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; NEURONS; PHOSPHOPYRUVATE HYDRATASE; PYROPTOSIS; RATS; RATS, SPRAGUE-DAWLEY; YOUNG ADULT;

EID: 84934989890     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-014-0233-0     Document Type: Article

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